Elisabetta Kuhn
I am a Surgical and Molecular Pathologist with a dedicated interest in gynecological diseases. I received my M.D. from the Bologna University School of Medicine and completed the Anatomic Pathology Residency Program at the University of Milan. After my training, I devoted myself to cancer research with a specific focus on gynecological and breast malignancies. Currently, I am a scientist at the University of Milan.
Molecular Alterations in Ovarian Endometriosis
Endometriosis is a benign disease with biological features characteristic of malignant tumors, such as invasiveness and migration abilities. In epithelial malignant tumors, it is believed that epithelial-mesenchymal transition (EMT), that is, the switch of an epithelial phenotype versus a mesenchymal one, allows for cell polarity and connection loss, favoring cell invasion and migration. Recent studies have reported the role of EMT in endometriosis. JARID2 plays an important role in the EMT of several cancers, but its role in endometriosis is…
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Reevaluating response and failure of medical treatment of endometriosis
Endometriosis is a chronic disease affecting more than 10% of women in the fertile age and causing "pain" symptoms, that may require medical therapy. Most medical treatments used for endometriosis exert a hormonal mechanism to curtail estrogen effects either locally or systemically. Dr. Becker and coauthors recently published in Fertility and Sterility a systematic review study that aimed to assess the efficacy of medical treatments currently used to relieve endometriosis-associated pain. This study reported a substantial reduction in pain symptoms…
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