Hale Goksever Celik, MD
Dr. Goksever Celik is an obstetrician and gynecologist, graduated from the medical school of the Hacettepe University in Ankara, and trained through Obstetrics and Gynecology fellowship at Dokuz Eylul University in Izmir. She has been a postdoctoral research fellow at Molecular Biology and Genetics at Istanbul University. She has been participating in several research especially interested in the association between endometriosis surgery and ovarian reserve and the genetic basis of endometriosis.
Postoperative Outcomes in Women After Sacral Plexus Deep Endometriosis Resection
Deep endometriosis refers to a severe form of endometriosis where tissue grows deeply into the pelvic and abdominal organs, including the bowel, bladder, nerves, and blood vessels. When the disease affects the sacral plexus, which is a network of nerves at the base of the spine, it can lead to severe nerve pain, known as sacral radiculopathy. This occurs when the endometriotic lesions compress, irritate, or invade the sacral nerve roots (S1-S4) or the fibers of the sciatic nerve. Women with sacral radiculopathy…
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Lifestyle and Environmental Factors in Endometriosis: Current Insights and Future Directions
Endometriosis-associated symptoms such as dysmenorrhea, dyspareunia, chronic pelvic pain have an effect to diminish the quality of life. The physical and mental quality of life of these women is adversely affected. There are several studies evaluating the quality of life and environmental factors in endometriosis patients. Researchers in the U.S., led by Lalla et al., recently published a review titled "Impact of Lifestyle and Dietary Modifications for Endometriosis Development and Symptom Management" in Current Opinion in Obstetrics and Gynecology. This review focuses on…
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Does endometriosis have an adverse effect on sperm activity?
Infertility is one of the symptoms encountered in up to 40-50% of women with endometriosis. There are several pathophysiological theories suggesting the development of endometriosis-associated infertility such as altered pelvic anatomy, adhesions, disrupted ovarian reserve/function and compromised endometrial receptivity as well as systemic effects of the disease. There is limited evidence about the effect of sperm activity on endometriosis-associated infertility. Fenner A., published a research highlight entitled as “Sperm activity affected by endometriosis” in the Nature Reviews Urology. The author…
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Gluten-free diet fot endometriosis-associated gastrointestinal symptoms
Women with endometriosis often report gastrointestinal symptoms such as bloating, constipation, diarrhea, and abdominal cramping,may have a negative impact on women’s lives having endometriosis and which can mimic irritable bowel syndrome (IBS) leading to potential misdiagnosis. A commonly suggested dietary intervention is a gluten-free diet, often promoted on social media. While effective for conditions like non-celiac wheat sensitivity or celiac disease, its impact on endometriosis remains uncertain. vanHaap et al., from The Netherlands, published a study titled as “A gluten-free…
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Effects of Endometriosis Symptoms on Women's Overall Health and Well-Being
Endometriosis significantly affects women's quality of life. Many women face daily challenges due to pelvic pain, which can lead them to miss work or school and withdraw from social activities. It's crucial to assess and manage the symptoms associated with endometriosis to avoid these serious consequences. However, symptoms can vary widely among individuals. A group of Australian researchers led by Mitchell et al. published a study titled “The Most Impactful Endometriosis Symptom” in the journal Acta Obstetricia et Gynecologica Scandinavica.…
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Does a comprehensive interventional program improve sexual health in women with endometriosis?
Women with endometriosis suffer from dysmenorrhea, dyspareunia and chronic pelvic pain, all of which has significant negative consequences on their physical and psychological health regarding sexual and reproductive function. A group of scientists from Iran, published a study protocol titled “A comprehensive interventional program to improve the sexual function of women with endometriosis: a mixed‑methods protocol study” in the journal Reproductive Health. The authors aimed to evaluate whether there is an impact of the interventional programs on sexual function in reproductive-aged…
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Menstrual Health & Endometriosis Education Increases the Awareness in Students
The main symptoms of endometriosis include dysmenorrhea, dyspareunia, and chronic pelvic pain that may result in social and developmental disturbances such as abstinence from school or work. There is a significant diagnostic delay of endometriosis diagnosis, because symptoms may be ignored by both patients and clinicians. A group of researchers led by Dr.Yong, from Canada, published a study titled “Does Menstrual Health and Endometriosis Education Affect Knowledge Among Middle and Secondary School Students? A Cluster-Randomised Controlled Trial” in Journal of…
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Laparoscopic procedures can alleviate fatigue in women suffering from endometriosis
The most common symptoms of endometriosis include pelvic pain, dysmenorrhea, dyspareunia, and infertility. Effective management is essential due to the significant impact these symptoms have on a woman's quality of life. Fatigue, characterized by persistent and severe tiredness, is also linked to various chronic conditions, including rheumatological diseases and cancer. Reischer and colleagues from Austria published a study titled “Can Laparoscopic Surgery Reduce Fatigue in Women with Endometriosis? - A Pilot Study” in the Journal of Clinical Medicine. The…
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Endometriosis and musculoskeletal function of pelvic loin complex
Endometriosis is an inflammatory and estrogen-dependent disease which is diagnosed in reproductive-aged women most frequently. These women present with a broad clinical spectrum including pelvic pain, dysmenorrhea, dyspareunia and infertility. All of these symptoms and signs may harm women’s lives having endometriosis. Because of peripheral hypersensitivity, these women may have musculoskeletal dysfunction located in the pelvic loin complex. Silva de Barros et al., from Brazil, published a study titled as “Musculoskeletal evaluation of the lower pelvic complex in women…
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Diminished physical activity in women with endometriosis due to chronic pelvic pain
Endometriosis is a systemic, chronic, inflammatory disease defined as the localization of endometrial-like tissue outside the uterine cavity. Pelvic pain is the most common symptom in these women resulting in abstinence from school or work and psychosocial problems. Physical activity is also impaired in these women as repeated experiences of intense pain causing central sensitization in the brain. Some modifications in their physical ability to perform physical tasks have been observed in endometriosis patients. Researchers from Brazil, published a study…
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Endometriosis-associated symptoms have a negative impact on the quality of life in women
Women with endometriosis experience restrictions in their daily activities due to pelvic pain, resulting in abstinence from work or school and discontinuation of their social activities. Evaluation and management of endometriosis-associated symptoms is important to prevent these significant consequences. However, successful intervention may change between and within individuals depending on the individual's presentation and needs. Mitchell et al. from Australia, published a study titled “The “most bothersome symptom” construct: A qualitative study of Australians living with endometriosis” in the journal Acta…
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Dysmenorrhea in adolescent girls and the quality of life
Dysmenorrhea, also known as period pain, painful periods, or menstrual cramps, is pain during menstruation. Despite its high incidence, dysmenorrhea is often a stigmatized and normalized condition. However, it is known that painful periods cause abstinence from work or school resulting in decreased quality of daily life. Cameron et al. from Australia, published a study titled “Menstrual pain in Australian adolescent girls and its impact on regular activities: a population-based cohort analysis based on Longitudinal Study of Australian Children survey…
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Programmed Cell Death 1 Ligand Expression and Endometrioma Recurrence
Although there are several medical and surgical management options, endometriosis is highly prone to recurrence. A possible predictor of recurrence would be the quality of life for women with endometriosis. On the other hand, endometriosis is an immunological disease, there are many publications in the literature supporting this situation. Programmed cell death-1, expressed on the surface of activated T cells, B cells, and other lymphocytes, binds specifically with PD-L1 which has an immunosuppressive role by inhibiting T-cell activity. The interaction between…
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Does endometrioma alter the fecundity in mice?
Endometriotic women suffer from dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Although the exact mechanism explaining endometriosis-associated infertility has not been elucidated, distorted pelvic anatomy, impaired ovarian function, altered microenvironment, affecting endometrial receptivity, and embryo quality have been accepted as the most common responsible mechanisms. Park et al., from the Republic of Korea, published a study titled “Alteration in Effects of Endometriosis on Fecundity According to Pregnancy Experience in Mouse Model” in the medical journal named Reproductive Sciences. The authors aimed…
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Is there any relationship between age at diagnosis and the severity of endometriosis?
Endometriosis is an estrogen-dependent gynecological disease mostly encountered in reproductive-aged women. Early diagnosis is important, as endometriosis impairs the quality of life. The most accepted theory is that endometriosis is a progressive disease and its stage increases with age. Dr. Comptour et al. from France published a study titled “Endometriosis: Age at Diagnosis and the Severity of the Disease” in the Journal of Gynecology Obstetrics and Human Reproduction. The authors sought to investigate the effects of age at diagnosis of endometriosis…
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Psychological effect of endometriosis due to chronic pelvic pain
The most common symptoms of endometriosis are dysmenorrhea, dyspareunia, and chronic pelvic pain, all of which affect the quality of women’s lives. Early diagnosis and management are important as endometriosis impairs the quality of life of patients and creates a serious social and economic burden. Two scientists from the Department of Clinical, Educational & Health Psychology, University College London, United Kingdom, published “A thematic synthesis of qualitative studies and surveys of the psychological experience of painful endometriosis” in the BMC Women’s…
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Are women with endometriosis more prone to have mental health disorders?
Endometriosis is a long-term morbidity resulting in impaired physical, sexual, psychological, and social health. The most common clinical findings of endometriosis patients are chronic pelvic pain and fertility problems, associated with impaired quality of life. These women are also affected regarding psychological health due to disease-associated symptoms. A group of scientists from Austria led by Dr.Seeber published a systematic literature review entitled “Endometriosis and mental health disorders: identification and treatment as part of a multimodal approach” in the journal named Fertility…
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Is post-cesarean pain perception and analgesic use in endometriosis-affected women different?
It has been known that endometriosis patients have increased pain sensitivity and different reactions to pain compared to women having no endometriosis. Several mechanisms such as nociception, inflammation, and changes in peripheral and central nervous system pain processing have been proposed to explain this altered pain perception. Heresco et al.from Israel published a retrospective case-control study titled “Pain perception and analgesic use after cesarean delivery among women with endometriosis” in the European Journal of Obstetrics & Gynecology and Reproductive Biology. The…
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Complementary and alternative therapies for managing acyclic pelvic pain in women with endometriosis
The quality of life in women with endometriosis is affected depending on the symptoms and signs of endometriosis such as dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Because of different clinical spectrum and diagnostic delays, there is no optimum management method in all women with endometriosis. Expectant, medical, or surgical methods are personalized depending on the patient’s clinical presentation and gynecologic evaluation. Mongiovi et al., from the United States, published a longitudinal cohort study titled “Differences in characteristics and use of…
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Endometriosis and the risk to have mental disorders
The most common clinical findings of endometriosis patients are pelvic pain and fertility problems, resulting in impairment of quality of life. These women are also affected regarding psychological health due to disease-associated symptoms. Dr. Wang et al., from Taiwan, published a study titled “Association Between Endometriosis and Mental Disorders Including Psychiatric Disorders, Suicide, and All-Cause Mortality-A Nationwide Population-Based Cohort Study in Taiwan” in the International Journal of Women’s Health. In this study, the authors aimed to evaluate whether there was any…
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