Therapeutics that target the steroid hormones are the standard treatment for women with endometriosis because steroid hormones play an important role in endometrial physiology and pathogenesis of endometriosis. Examples of these therapeutics include anti-estrogens, estrogen receptor (ER) modulators, progestins, and progesterone receptor (PR) modulators. Despite the frequent use in endometriosis, clinical data suggest that almost one-third of endometriosis does not respond to combined oral contraceptives and progestin therapies. Women with endometriosis often can recur after cessation with these therapies. Although…
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The symptoms of endometriosis are varied among women and include chronic pelvic pain, infertility, and fatigue. There are no reliable blood tests and medical imaging techniques such as MRI and ultrasound are not always satisfactory. The lack of endometriosis-specific symptoms and biomarker assays makes it difficult to diagnose endometriosis. Hence, there is a significant delay in endometriosis diagnosis relative to the time of symptom onset. The delays can be as long as 7-10 years even in countries such as the…
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Lay Summary