Unviling the role of PD-1-PD-L1 Pathway in Endometriosis Progression and Therapy
The role of immune system in Endometriosis, a chronic inflammatory disease is complex, involving both protective and harmful effects. A key player in this process is PD-1 (programmed cell death protein 1), a protein found on T cells that regulates immune responses by inhibiting…
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By Yu YuWhite blood cell neutrophils link to immunosuppressive environment in ovarian endometrioma
By Yu Yu
Recently the contribution of neutrophils to the pathogenesis of endometriosis has been suggested. Several observations fuelled this suggestion, such as the accumulation of neutrophils in the peritoneal fluid of ovarian endometriosis; neutrophil extracellular traps were found in the peritoneal fluid of…
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By Irem OnurProgrammed-cell death pathway and immune dysfunction in endometriosis
By Irem Onur
Endometriosis is an estrogen-dependent, immune-associated disease. Women with endometriosis have different proportions of the activated forms of immunocompetent cells, such as T cells and macrophages compared to those from women without. Immune cell dysfunction in the uterine and abdominal cavity…
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