By Yu YuEndometriosis Knowledgebase
By Yu Yu
Several studies have pointed to possible genetic factors in endometriosis. Targeted gene-based and high-throughput methods such as Genome-Wide Association Studies (GWAS) have been previously employed to identify endometriosis-associated genes. However, the accuracy of these data are difficult to evaluate and…
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By Özge ÖzkayaAnother Genetic Polymorphism That May Increase Risk of Endo
By Özge Özkaya
A single letter change in the Epidermal Growth Factor Receptor (EGFR) gene may significantly increase the risk of endometriosis. This is according to a study conducted among women in Southwest China and published in the journal Medicine. Identifying genetic risk…
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By Kasthuri NairEndometriosis-associated Gene Polymorphisms in Women of Greek Origin
By Kasthuri Nair
Endometriosis research has yet to elucidate the genetic and environmental mechanisms that contribute to the rise of the disease. In their paper titled “The role of gene polymorphisms in endometriosis,” Matalliotakis et al. concentrate on the genetic component of the…
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Protein-Modifying Variants in the Genome and Their Role in Endometriosis
By Kasthuri Nair
The results of many endometriosis studies are limited in the fact that they only recruit patients from one geographical area; however, this particular study specifically narrowed their participant search to individuals from one continent, namely Europe. Sapkota et al. chose…
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By Murat OsmanThe role of gene polymorphisms in the pathogenesis of endometriosis
By Murat Osman
Single nucleotide polymorphisms (SNPs) are the most common type of genetic variations that exist among individuals. These polymorphisms differ by a single nucleotide base pair and are scattered throughout the human genome. Scientists use SNPs as a biological marker to…
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Single Nucleotide Polymorphisms Play a Role in Endometriosis Related Infertility
By Kasthuri Nair
In their paper titled “Endometriosis-associated infertility: GDF-9, AMH, AMHR2 genes polymorphisms,” De Conto et al. attempt to elucidate the mechanism that leads to endometriosis-related infertility. In short, the authors hypothesize that there is a connection between polymorphisms in the Growth…
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Updates in the Field of Endometriosis: Genetics
By Kasthuri Nair
This chapter written by Krishnamoorthy and Decherney re-evaluate the literature concerning the genetics of endometriosis. The genetic mechanisms and signaling pathways that led to endometriosis are updated and the tools that help researchers find these abnormal genes and pathways are…
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