By Eylül GÜNThe role of coagulation factors and tumor markers in diagnosing advanced stage endometriosis
By Eylül GÜN
As a systemic inflammatory condition, endometriosis features elevated proinflammatory cytokines, causing pain, endothelial dysfunction, carcinogenesis, and a hypercoagulable state. Patients with endometriosis show decreased thrombin time (TT) and activated partial thromboplastin time (APTT), alongside increased tissue factor (TF) and fibrinogen…
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By Hale Goksever CelikProgrammed Cell Death 1 Ligand Expression and Endometrioma Recurrence
By Hale Goksever Celik
Although there are several medical and surgical management options, endometriosis is highly prone to recurrence. A possible predictor of recurrence would be the quality of life for women with endometriosis. On the other hand, endometriosis is an immunological disease, there…
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Blood-based biomarkers for the detection of endometriosis and adenomyosis
By Eylül GÜN
One of the biggest challenges in endometriosis management is the delay in diagnosis. Scientists have been trying to come up with biomarkers to detect it quicker. Thinking blood-based biomarkers could aid in earlier diagnosis and help with the duly administration…
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A suggestion for a novel in vitro diagnostic test for endometriosis
By Eylül GÜN
As the research continues to find a gold standard non-invasive diagnostic method for endometriosis, there still is no definitive answer. One of the most commonly studied markers is Cancer Antigen 125 (CA125) – a biomarker that is secreted from the…
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The relationship between lipids and estrogen in endometriosis
By Eylül GÜN
Lipid metabolism plays important roles in many physiological and pathological conditions such as the storage of energy, immune system functions, steroid hormone production, inflammation, and chronic diseases such as diabetes mellitus and hyperlipidemia. In an attempt to figure out the…
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Postoperative serum markers to predict serum AMH recovery following endometriosis surgery
By Hale Goksever Celik
Women with endometriosis seek treatment including ovarian cystectomy, because of symptoms that reduce their quality of life. Ovarian cystectomy using laparoscopic or robotic devices is the preferred therapy. However, it has been shown in the literature that ovarian reserve is…
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By Bahar YukselTurn around to come to the same spot: Nothing specific to predict AMH decline
By Bahar Yuksel
Endometriomas are challenging lesions as they might cause a decline in ovarian function either only by their presence or related to their surgery. Thus, any preoperative parameter that might give a vision to a surgeon for postoperative results is crucial.…
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By Nasuhi Engin AydinCombined "Platelet-to-lymphocyte ratio and CA125" may be promising predictor for adhesions
By Nasuhi Engin Aydin
Drs. Guo & Zhang from the Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China published their manuscript on the importance of combined "platelet-to-lymphocyte ratio and CA125 level" as a biomarker of endometriosis in a recent…
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How possible is it to diagnose endometriosis from a urine sample?
By Eylül GÜN
The development of non-invasive diagnostic methods in endometriosis is essential for successful surveillance. Various biomarkers have been used for this purpose, including biomarkers from serum, peritoneal irrigation fluid, endometrial tissue biopsy, and urine. Dr. Chen et al. from Taiwan conducted…
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Exploring a bonafide biomarker to predict endometriosis
By Eylül GÜN
Endometriosis is a complex disease affecting many women in the reproductive age group. As it is important to figure out the mechanisms responsible for the disease, it is also crucial to identify biomarkers that can be used in the diagnosis…
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By Timur SeckinCombination of noninvasive biomarkers in the identification of endometriosis
By Timur Seckin
The combined measurement of urine enolase, serum CA125, and CA19-9 may be an accurate test for the prediction and detection of endometriosis. This is according to a study published in the journal BioMedical Research International. The gold standard for the…
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By Ellen TumimbangCA125 do not correlate with pain and its severity among adolescents
By Ellen Tumimbang
Cancer antigen 125 (CA125) is a high molecular weight glycoprotein expressed in tissue derived from the coelomic and Mullerian epithelia including the uterus endometrium. Previous studies reported that CA125 is the most studied endometriosis marker. Women with endometriosis experienced different…
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Non‑invasive biomarkers for endometriosis diagnosis
By Hale Goksever Celik
Endometriosis is a disease of women in reproductive age and its incidence varies between 5-10%. Since the diagnosis is based on the histological confirmation, there is an average of 7 to 11 years of delays in the diagnosis. Promising non-invasive…
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By Kasthuri NairHOXA10: A Culprit in Endometriosis Disease Progression
By Kasthuri Nair
Zheng et al., a group of authors from the Aerospace Center Hospital in Bejing and from the First Affiliated Hospital of Wenzhou Medical University in Wenzhou, recently published a paper in Reproductive Sciences entitled “Decreased Expression of HOXA10 May Activate the…
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