Metabolic and Cellular Changes in Adolescent Peritoneal Endometriosis
In a study published in the International Journal of Molecular Sciences, Khashchenko et al. explored the association of cellular and exosomal markers of glycolysis, mitochondrial biogenesis, apoptosis, autophagy, and estrogen signaling in peritoneal endometriosis among adolescents to understand early disease-related metabolic reprogramming. This case–control…
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By Özge ÖzkayaEndometriosis May Be Identified Using a Standardized Questionnaire
By Özge Özkaya
Screening adolescents and young adult women with a questionnaire can identify clinical symptoms associated with histologically proven endometriosis, according to a new study published in the scientific journal Human Reproduction. “Combined with imaging and clinical examination, this approach will enable…
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GP Records May Hold Information About Possible Endometriosis in Adolescents
By Özge Özkaya
The prevalence of coded dysmenorrhoea in the records of general practitioners (GP) is significantly lower than what is suggested in community surveys, according to a new study published in the British Journal of General Practice. However, menstrual symptoms in adolescents are commonly seen…
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By Hale Goksever CelikMenstrual Health & Endometriosis Education Increases the Awareness in Students
By Hale Goksever Celik
The main symptoms of endometriosis include dysmenorrhea, dyspareunia, and chronic pelvic pain that may result in social and developmental disturbances such as abstinence from school or work. There is a significant diagnostic delay of endometriosis diagnosis, because symptoms may be…
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By Selma OransayEarly use of hormonal contraceptives and the probability of endometriosis diagnosis later in life
By Selma Oransay
Hormonal contraceptives are the first-line medical treatment of endometriosis. If an adolescent has chronic pelvic pain and is an "unresponder" to hormonal therapy, the likelihood of having an "endometriosis diagnosis" is higher. This sign should warn clinicians about endometriosis diagnosis…
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By Eylül GÜNQuercetin and its effects on endometriosis
By Eylül GÜN
Endometriosis, as a disease characterized by chronic inflammation and fibrosis, could be a potential target for quercetin, a flavonoid found in various foods and botanicals, and a known senolytic agent with many effects including antioxidant, anti-inflammatory, and immune-modulatory properties. Studies…
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Early diagnosis of deep infiltrating endometriosis in adolescence
By Selma Oransay
Dysmenorrhea is widely observed in adolescence, and endometriosis is one of its causes. However, endometriosis diagnosis is usually made after 25 years of age. It is clear that early diagnosis and management of this progressive disease is essential and will…
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Complementary and alternative therapies for managing acyclic pelvic pain in women with endometriosis
By Hale Goksever Celik
The quality of life in women with endometriosis is affected depending on the symptoms and signs of endometriosis such as dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Because of different clinical spectrum and diagnostic delays, there is no optimum management…
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Peritoneal fluid in young women with endometriosis
By Selma Oransay
Many blood substances are present in peritoneal fluid due to their derivation from the transudation of blood through the peritoneal surface. Ectopic endometriotic lesions can also change the medium to contribute to the definition of the local environment of the…
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Underestimation of Dysmenorrhea in adolescents
By Hale Goksever Celik
Women with endometriosis may suffer from painful symptoms, especially during menstruation or sexual intercourse. One of the main etiologic reasons for secondary dysmenorrhea is endometriosis, and it has a poor impact on life quality. Underestimation of dysmenorrhea and consideration of…
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By Nasuhi Engin AydinVicious cycle: The promoting role of previous endometriosis foci for new lesions
By Nasuhi Engin Aydin
An experimental animal study on the pathogenesis of endometriosis from the Institute for Clinical and Experimental Surgery, Saarland University, Hamburg has been published in a recent issue of International Journal of Molecular Sciences. Endometriosis is a well-known common gynecological ailment…
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Younger Women With Endometriosis Feel More Pain
By Özge Özkaya
Younger women with endometriosis feel more period pain (dysmenorrhea) and pain during intercourse (dyspareunia) compared to older women with the disease, found a new study published in the Journal of Pediatric and Adolescent Gynecology. Acknowledging this fact can make sure…
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Creating a reliable indirect immunofluorescence protocol as a promising diagnostic tool for endometriosis
By Eylül GÜN
Owing to its inflammatory nature, endometriosis results in the overproduction of reactive oxygen species (ROS) which disrupt the cellular functions and eventually lead the cell to apoptosis and cell cycle arrest. Senescence, the natural state of irreversible cell cycle arrest,…
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Taller Girls More Likely to Have Recurring Endometriosis
By Özge Özkaya
Adolescents who are taller and have three or more lesions are at a higher risk of endometriosis recurrence following surgery, according to a new study by Chinese researchers published in the Journal of Obstetrics and Gynaecology. They should, therefore, be…
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Pelvic pain characteristics in young girls with endometriosis.
By Selma Oransay
The occurrence of severe and frequent pelvic pain in young women is a piece of evidence that endometriosis begins and develops at an early age. Two-thirds of women with endometriosis who were diagnosed in their adulthood reported the onset of…
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Research Identifies Blood Proteins Associated With Endometriosis in Adolescents
By Özge Özkaya
Proteins related to angiogenesis or the formation of new blood vessels and cellular migration are enriched and more active in the blood of adolescents with endometriosis compared to healthy controls. These are the findings of a new study published in…
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Listening to patients’ complaints is the first step on the way to a diagnosis of endometriosis.
By Hale Goksever Celik
Early diagnosis and management of endometriosis are not possible due to the wide spectrum of symptoms and absence of non-invasive diagnostic biomarkers. Particularly the adolescent population is at risk for the diagnostic delay because pelvic pain and dysmenorrhea are very…
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Endometriosis diagnosis and management based on the best available evidence from published literature
By Selma Oransay
ESHRE, "European Society of Human Reproduction and Embryology" published a Guideline for the diagnosis and treatment of endometriosis in 2005 and then revised it in 2013. Based on new research and development there was a need to renew the last…
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Adenomyosis in adolescents
By Nasuhi Engin Aydin
Dr. Exacoustos and colleagues from two tertiary referral university hospitals in Italy published their results on adenomyosis in adolescent patients in a recent issue of “The Journal of Minimally Invasive Gynecology”. Adenomyosis is the presence of endometrial glands and stroma…
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Endometriosis & adolescents: Overcoming the diagnostic delay via education
By Eylül GÜN
Although the diagnosis of endometriosis is still not timely even in adults, due to its common under- or misdiagnosis in adolescents, the diagnostic delay may further cause the adolescent women to wait to seek medical treatment. A group of researchers…
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The association of chronic endometritis, endometriosis and tubal infertility
By Selma Oransay
Holzer et al. from the Department of Gynecologic Endocrinology and Reproductive Medicine of Medical University of Vienna, Austria, set up apilot prospective cohort study to evaluate the relationship between chronic endometritis, infertility and endometriosis. The results of the study were recently…
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Insoluble Dilemma of Adenomyosis: Diagnosis, Management, and Treatment - Errico Zupi, MD
By Selma Oransay
The prevalence of adenomyosis has been reported to range from 1% to 70% in different studies. This large range can be explained by the lack of standard diagnostic criteria by imaging modalities or pathological analyses. Sixty-five% of the women with adenomyosis…
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By Irem OnurAdolescent endometriosis: Diagnostic clues?
By Irem Onur
The rates of dysmenorrhea, dyspareunia, and heavy menstrual bleeding in adolescents showing endometriosis signs on ultrasound are significantly higher compared to those without. This is according to a retrospective observational study recently published in the journal "Fertility and Sterility". The…
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By Ellen TumimbangCA125 do not correlate with pain and its severity among adolescents
By Ellen Tumimbang
Cancer antigen 125 (CA125) is a high molecular weight glycoprotein expressed in tissue derived from the coelomic and Mullerian epithelia including the uterus endometrium. Previous studies reported that CA125 is the most studied endometriosis marker. Women with endometriosis experienced different…
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The peculiarity of adolescent endometriosis
By Selma Oransay
Recent studies showed the prevalence of endometriosis in adolescents with chronic cyclic or acyclic pelvic pain is about 60-70%. Moreover, all stages of endometriosis, including deeply infiltrating endometriosis can be found in this population. Gubbels et al. from the Department…
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By Yu YuInhibiting killer on the move
By Yu Yu
The three main forms of endometriosis are superficial, ovarian, and deep endometriosis. The latter is defined by the presence of endometriotic nodules that are deeper than 5 mm. Deep endometriosis is considered the most aggressive and is associated with severe…
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The Impact of Painful Sex on the Physical and Mental Wellbeing of Adolescent and Young Adult Women
By Özge Özkaya
Clinicians should ask adolescents and young women about painful sex, not just talk about contraception and the prevention of sexually transmitted diseases. This is because painful sexual intercourse could have a negative impact on relationships and peer engagement, which is…
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Endometriosis prevalence among adolescents with pelvic pain
By Irem Onur
An updated review conducted by the investigators at EGA Institute for Women's Health, University College London, United Kingdom, in collaboration with Birmingham Women’s and Children’s Foundation Trust of the Institute of Metabolism and Systems Research at the University of Birmingham…
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Endometriosis Impacts Transgender Adolescents
By Irem Onur
Shim J.Y. et al, from Boston, Massachusetts retrospectively searched the electronic medical records of transmasculine patients younger than 26 years old who were diagnosed with dysmenorrhea and treated at Boston Children’s Hospital, between January 1, 2000, and March 1, 2020.…
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By Timur SeckinAdolescent endometriosis
By Timur Seckin
A recent article, led by experts from Peking Medical Union College, describes the clinical characteristics and postoperative symptoms of adolescent endometriosis. The authors inform that their report, which is published in the "Journal of Pediatric and Adolescent Gynecology", can provide…
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Adolescent dysmenorrhea diagnosis and management
By Hale Goksever Celik
Endometriosis is usually diagnosed in reproductive-aged women. However, recent literature proved that clinical symptoms of endometriosis are also seen the adolescent girls and young women. Dysmenorrhea, the most common gynecologic complaint among this age group, can develop due to endometriosis.…
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Progressive nature of ovarian endometrioma
By Yu Yu
The effective management of endometriosis requires a proper understanding of how the condition progress as women age, especially for those women with early onset of endometriosis. Several studies have tried to characterize the evolution of endometriosis. Some of the key…
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A review of endometriosis in adolescent girls and young women
By Hale Goksever Celik
Endometriosis is an estrogen-dependent disease which is commonly diagnosed in reproductive-aged women. On the other hand, this disease can develop earlier in life due to different etiopathogenetic mechanisms. Especially adolescents who experienced neonatal uterine bleeding are under the risk for…
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Adolescent dysmenorrhea and future endometriosis
By Selma Oransay
Dysmenorrhoea is typically classified as primary, or secondary due to underlying pathologies like fibroids, endometriosis, adenomyosis or uterine anomalies. Generally, long-term dysmenorrhea is present in endometriotic patient's anamnesis, but until recently, the research to clarify this connection remained retrospective. Knox et…
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By Deniz KocasPrescription Opioid Use in Women With Endometriosis
By Deniz Kocas
In this study, researchers examined opioid use, opioid prescribing patterns, and timing of the first opioid prescription in endometriosis patients compared with matched women in the control group without endometriosis. A retrospective analysis of Optum Clinformatics Data Mart was conducted.…
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Health care resource utilization and cost in women with endometriosis
By Hale Goksever Celik
Endometriosis is a chronic inflammatory disease affecting 6-10% of reproductive-aged women. The clinical picture of the disease range from asymptomatic findings to dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Endometriosis has also complex etiopathogenetic background. This broad clinical spectrum, the…
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The diagnosis and management of endometriosis in Korea
By Selma Oransay
The Korean Society of Endometriosis has scrutinized the present published literature of endometriosis in the domestic and international platform to provide new guidelines and the clinical management of the disease. The study was recently published in the journal "Obstetrics and Gynecology…
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Endometriosis in adolescents
By Irem Onur
Dr. Mama S. T. from Cooper University Hospital, Camden, New Jersey, USA, recently has published his review on advances in the management of endometriosis in the adolescent in the journal “Current Opinion Obstetrics and Gynecology”. In adolescence, there is a…
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Fluorescence Guided Surgery: a New Technique to Treat Deep Infiltrating Endometriosis
By Özge Özkaya
Fluorescence-guided surgery could help differentiate recto-vaginal deep infiltrating endometriosis nodules (RVDIEN) from healthy rectal tissue and remove them successfully without perforating the rectum, according to a study published in the scientific journal Surgical Innovation. The method could offer a better,…
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Impact of coping strategies on quality of life of adolescents and young women with endometriosis.
By Deniz Kocas
González-Echevarría et al. report in J Psychosom Obstet Gynaecol. that symptoms caused by endometriosis have been found to be associated with negative quality of life (QoL) in women with endometriosis and the type of coping strategies adopted by patients have been shown…
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By Kasthuri NairKey to Understanding Ovarian Endometriosis may lay in the Peptides
By Kasthuri Nair
Xue et al. recently published a paper titled “Peptidomic Analysis of Endometrial Tissue from Patients with Ovarian Endometriosis” in Cellular Physiology and Biochemistry. The research group from various departments of Nanjing Medical University wished to better understand the pathogenesis of…
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By Dr. Youngran ParkHow do adolescent girls and boys perceive symptoms suggestive of endometriosis among their peers?
By Dr. Youngran Park
Endometriosis, a chronic condition characterized by cells similar to the uterine lining that exist outside of the uterus, is estimated to impact 10% of women of reproductive age. In the USA, that approximates to some 7.4 million women. Endometriosis has…
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No Link Found Between Vitamin D and Endometriosis
By Kasthuri Nair
Buggio et al., a group of scientists from the Ospedale Maggiore Policlinico, Universita` degli Studi in Milan, recently published a paper in the Reproductive Sciences titled “25-Hydroxyvitamin D Serum Levels and Endometriosis: Results of a Case-Control Study.” The publication sought…
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Treatment of Endometriosis in Adolescents
By Özge Özkaya
Most women with endometriosis who have been treated with Lupron plus add back as adolescents felt the treatment was effective in reducing the pain caused by the condition, according to a study published in the Journal of Pediatric & Adolescent…
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Adolescents with Endometriosis are More Susceptible to Migraines
By Kasthuri Nair
Miller et al. recently published an article titled “The prevalence of migraines in adolescents with endometriosis” in Fertility and Sterility. The main purpose of the study was to determine if adolescents with endometriosis experience more migraines than those without endometriosis.…
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By Murat OsmanDiagnosis and management of adolescent endometriosis
By Murat Osman
Early onset endometriosis (EOE) is characterized by endometriosis that begins around menarche or early adolescence. Recent evidence suggests that this form of endometriosis may have a different pathogenic origin than that of adult-onset endometriosis. This opinion article suggests that early…
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Do Adolescents and Adults Experience Endometriosis Differently?
By Özge Özkaya
Symptoms of endometriosis seem to be the same between women surgically diagnosed during adolescence and those diagnosed as adults, according to a study published in the American Journal of Obstetrics and Gynecology. For both age groups, pelvic pain was severe,…
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High-Mobility Group Box 1 Expression Could Lead to Disease Progression
By Kasthuri Nair
Endometriosis can often be characterized by the aberrant ectopic growth of endometriotic stromal cells (ESCs); however, research has yet to elucidate the mechanism driving this growth. The authors of this study, namely Shimizu et al., believe that the high-mobility group…
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CCL19/CCR7 Interaction can Casue Characteristic Cell Proliferation
By Kasthuri Nair
In their paper published in the American Journal of Reproductive Immunology titled “CCL19/CCR7 contributes to the pathogenesis of endometriosis via PI3K/Akt pathway by regulating the proliferation and invasion of ESCs,” Diao et al. hope to elucidate one of the mechanisms…
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Ping-Chong-Jiang-Ni Formula: A Natural Treatment
By Kasthuri Nair
In the world of modern medicine, natural and herbal remedies are often under utilized. Liang et al. recently published an article in Evidence-Based Complementary and Alternative Medicine where they explored the benefits of using a Chinese Herbal Medicine to treat…
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Endometriosis Micrometastasis
By Yu Yu
Micrometastasis is used to describe the migration of a small number of cancer cells from its original location to the other organs within the body. While endometriosis is not cancer, it occurs when endometrial cells migrate outside of the uterus…
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