Endometriosis vs. adenomyosis : is there a common pathogenesis ?
This is a collaborative review on the pathophysiology of adenomyosis and endometriosis by academicians of the University of Leicester, UK; Fudan University, Shanghai, China and Sapienza University of Rome, Italy, published in a recent issue of “Biomolecules”. The pathophysiology of…
Key Points Lay SummaryA synopsis of deep infiltrating endometriosis of the digestive system
The gastrointestinal tract is one of the most common locations of extrapelvic endometriosis. Its infiltrative counterpart exhibits more aggressive behavior and often needs to be distinguished from malignancies clinically. Yin et al. from Harbin, China reviewed the latest findings regarding…
Key Points Lay SummaryA novel in-vitro endometriosis model with KRAS and PIK3CA mutations
A plethora of research has been ongoing to illuminate the pathogenesis of endometriosis which is a multifactorial disease. These studies have proven the association between some mutated cancer driver genes and endometriosis, and links between certain cancers such as ovarian…
Key Points Lay SummaryThe genetic mutations in uterine adenomyosis
Adenomyosis is defined as the localization of endometrial stromal and glandular cells in the myometrium. This disease is a reproductive-aged women disease, like endometriosis. Additionally, adenomyosis is frequently observed together with endometriosis and leiomyomas due to common histological features and…
Key Points Lay SummaryMutations Associated with Cancer Were Identified in "Endometriosis without Cancer"
Lesions in deep infiltrating endometriosis harbor genetic mutations that are associated with cancer, found a study published in the New England Journal of Medicine. The authors believe that this new discovery may help to distinguish between aggressive and non-aggressive forms of…
Lay Summary