By Eylül GÜNCellular Interactions Driving Peritoneal Endometriosis
By Eylül GÜN
A recent study led by Dr.Fazlaebas from the USA, published in the January 2025 issue of iScience, einvestigated the genes and cellular pathways involved in the development of peritoneal endometriosis. Using spatial transcriptomics, the study identified cell type-specific gene expression changes and…
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Macrophage Phenotypes Induced by Circulating Extracellular Vesicles in Endometriosis
In a study published in the Biomolecules, Martínez-Zamora et al. investigated the potential effect of circulating sEVs in the plasma of well-characterized patients with endometriosis on macrophage phenotype. This study explores how sEVs, which are tiny particles found in the blood of women…
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By Hale Goksever CelikThe enhanced invasiveness, migration and the development of adenomyosis: Importance of M2 macrophages
By Hale Goksever Celik
Adenomyosis is the ectopic presence of endometrial stromal and glandular cells inside the myometrial tissue. Adenomyosis is diagnosed in women with gynecological problems with an incidence of 20%, although it is encountered much more frequently in hysterectomy specimens. Among many…
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By Selma OransayMolecular and cellular mechanisms of fibrogenesis in endometriosis
By Selma Oransay
Endometriosis lesions are characterized by endometrium-like cell proliferation, invasion, and oxidative stress associated with inflammation and neoangiogenesis. Fibrosis, which occurs due to these events, causes chronic pelvic pain depending on the location and the severity of endometriosis. For the purpose…
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By Nasuhi Engin AydinA hot research topic: macrophage reprogramming for endometriosis treatment
By Nasuhi Engin Aydin
Daria Artemova and colleagues from several research institutes of the Russian Federation have published their review on the cellular aspects of endometriosis related to macrophages, particularly emphasizing promising therapeutic options for the future in "International Journal of Molecular Sciences". Macrophages have…
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By Nadire DuruIL-33 Polarize Peritoneal Macrophages for Endometriosis Growth
By Nadire Duru
M2 type macrophages are the most common type of macrophages found in endometriosis and they enhance the development of endometriosis lesions. The key factors that stimulate macrophages to polarize towards M2 and contribute to the increased endometriosis lesions remain to be…
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The role of microbiota in the etiopathogenesis of endometriosis
By Hale Goksever Celik
Endometriosis is an estrogen-dependent disease that is commonly diagnosed in reproductive-aged women. Although many advanced types of research about the etiology, differential diagnosis and treatment have been performed, it still remains an enigmatic disease. Dr. Bedaiwy, a scientist and physician…
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By Yu YuAltered Immunity in Endometriosis
By Yu Yu
In recent years, there has been increased attention on the role of immune system in endometriosis development. Normally, immune reactions are supposed to destroy endometrial cells seeding in the peritoneal cavity. Nonetheless, in endometriosis, these cells are able to evade,…
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By Dr. Youngran ParkInterleukin 6 secretion from activated macrophages promotes the migration of endometriotic epithelial cells
By Dr. Youngran Park
Endometriosis is a chronic inflammatory disease. Accumulating evidence suggests that endometriosis patients have a higher level of various inflammatory factors which are associated with the pathogenesis of the disease. Several studies have shown marked increases in macrophage populations and activity…
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By Kasthuri NairEFA Medical Conference 2017: "Hormone and Cytokine Sensitivity in Endometriosis" Presentation by Dr. Robert Taylor
By Kasthuri Nair
The first presenter of the “Estrogen from Inflammation to Cancer: A Distant Link?” section of EFA 2017 Medical Conference was Dr. Robert Taylor from Wake Forest University Health Sciences. Dr. Taylor’s presentation was titled “Hormone and Cytokine Sensitivity in Endometriosis.”…
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