Unviling the role of PD-1-PD-L1 Pathway in Endometriosis Progression and Therapy
The role of immune system in Endometriosis, a chronic inflammatory disease is complex, involving both protective and harmful effects. A key player in this process is PD-1 (programmed cell death protein 1), a protein found on T cells that regulates immune responses by inhibiting…
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By Hale Goksever CelikProgrammed Cell Death 1 Ligand Expression and Endometrioma Recurrence
By Hale Goksever Celik
Although there are several medical and surgical management options, endometriosis is highly prone to recurrence. A possible predictor of recurrence would be the quality of life for women with endometriosis. On the other hand, endometriosis is an immunological disease, there…
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By Eylül GÜNNew developments in endometriosis from a molecular and cellular standpoint
By Eylül GÜN
Researchers are making significant progress in endometriosis regarding molecular and cellular research, with collaborative efforts by clinicians, scientists, surgeons, and biostatisticians. Laganà et al. from Italy wrote an editorial regarding the recent special issue called "Molecular and Cellular Advances in Endometriosis Research…
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By Yu YuWhite blood cell neutrophils link to immunosuppressive environment in ovarian endometrioma
By Yu Yu
Recently the contribution of neutrophils to the pathogenesis of endometriosis has been suggested. Several observations fuelled this suggestion, such as the accumulation of neutrophils in the peritoneal fluid of ovarian endometriosis; neutrophil extracellular traps were found in the peritoneal fluid of…
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By Serdar BalciTargeted therapy biomarkers in endometriosis associated ovarian carcinomas
By Serdar Balci
Endometriosis in ovaries is a known precursor of endometrioid and clear cell carcinomas. They may be resistant to classical therapies. Researchers search for alternative and targeted therapy options. This study, from the University of Campinas, Campinas, São Paulo, Brazil, will be…
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By Irem OnurProgrammed-cell death pathway and immune dysfunction in endometriosis
By Irem Onur
Endometriosis is an estrogen-dependent, immune-associated disease. Women with endometriosis have different proportions of the activated forms of immunocompetent cells, such as T cells and macrophages compared to those from women without. Immune cell dysfunction in the uterine and abdominal cavity…
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