By Nasuhi Engin AydinGenomic evidence: The recognition of endometriosis as an inflammatory systemic disease
By Nasuhi Engin Aydin
Dr. Bao and associates from Shangai-China published a new article on the genomic features of endometriosis that could yield information on its inflammatory basis and possible therapeutic potential in a recent issue of “Frontiers ın Immunology”. Endometriosis is a systemic process…
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By Bahar YukselWomen reject using hormonal drugs for endometriosis, an accelerating need for nonhormonal medications
By Bahar Yuksel
Although the pathophysiology of endometriosis is poorly understood, endocrine drugs are widely used for reducing inflammation and patients’ symptoms. Burla and colleagues aimed to evaluate the patients’ thoughts and expectations about the endocrine drugs which are used in the treatment…
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By Selma OransayWhat is the cause of Dienogest-resistance in patients with endometrioma?
By Selma Oransay
Endometriosis may cause infertility in women, leading to adhesions in the pelvis, besides affecting the ovaries. Clinicians concern about the child-bearing desire of their patients when treating them surgically or with hormonal therapy. Dienogest (DNG) is a kind of progestin,…
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The peculiarity of adolescent endometriosis
By Selma Oransay
Recent studies showed the prevalence of endometriosis in adolescents with chronic cyclic or acyclic pelvic pain is about 60-70%. Moreover, all stages of endometriosis, including deeply infiltrating endometriosis can be found in this population. Gubbels et al. from the Department…
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By Yu YuEndometriotic mesenchymal stem cells may promote endometriosis
By Yu Yu
The cause of endometriosis is still debatable. Many researchers have accepted that retrograde menstruation, where the endometrial fragments released during menstruation attach and colonize the ectopic locations, is the most plausible reason. However, the numbers just do not add up.…
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Opioids use in women with endometriosis, what does it tell us?
By Yu Yu
Endometriosis is a debilitating disease that can cause many painful symptoms such as dysmenorrhea, dyspareunia, infertility, chronic pelvic pain, abdominal pain, and sacral or low back pain. More than half of women diagnosed with endometriosis suffer from chronic pelvic pain.…
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Crocin improves endometriosis
By Yu Yu
Crocin is a carotenoid chemical compound in the flowers crocus and gardenia. It is one of the most important gradients in saffron. Previous studies showed that crocin may have multiple pharmacological effects including anti-tumor, anti-oxidant and anti-inflammation. There are several…
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By Özge ÖzkayaFDA Approves Endometriosis Pain Treatment
By Özge Özkaya
The U.S. Food and Drug Administration (FDA) approved a new medication for the treatment of moderate to severe pain associated with endometriosis, making it the first treatment to be approved in 10 years. The decision was announced in the Journal…
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Therapeutic potential of ginseng based compound in preclinical models of endometriosis
By Yu Yu
Currently, the drug option for women with endometriosis mainly focus on reducing estrogens levels (e.g., progestins, androgens, gonadotropin-releasing hormone (GnRH) agonists, and aromatase inhibitors). However, these therapies can have low effectiveness with frequent recurrence and considerable side effects. Therefore, there…
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Oral Contraceptives and Low-Cost Progestins to Reduce Endometriosis-Associated Pain
By Özge Özkaya
Most women with endometriosis-associated pain did not feel the need to use expensive progestin or undergo surgery. Instead, they were satisfied with a low-cost progestin to treat their symptoms. This is according to a study published in the journal Fertility…
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By Murat OsmanEmerging medical treatments for endometriosis
By Murat Osman
Endometriosis is a disease whereby uterine tissue grows outside the walls of the uterus to the surfaces of other tissues in the body. It is a chronic disease and relies upon estrogen to grow and survive. Current medical therapies take…
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Investigational drugs for the treatment of endometriosis
By Yu Yu
Endometriosis treatment involves surgery and medical therapies. Surgery can improve the associated pain, quality of life and sexual function, even though it is technically challenging with potential risks of complications. Medical therapy is often aimed to ameliorate pain symptoms and…
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The effect of anti-rheumatic drugs on endometriosis therapeutic outcomes
By Yu Yu
Endometriosis can be described as an autoimmune disease because the abnormalities associated with T and B cell function and various autoantibodies. Although endometriosis has not been found to associate with some severe autoimmune disorders such as systemic lupus erythematosus, it…
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Comprehensive review on the drug delivery options being used for endometriosis and uterine fibroids.
By Murat Osman
Both endometriosis and uterine fibroids (uterine leiomyomas) contribute to infertility, chronic pain, and dysmenorrhea across the world. Thus, drug delivery methods ranging from contraceptives to biochemical systems based on nanotechnology are currently being used and developed. Specifically, long-acting implantable contraceptives…
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The dose of the GnRHa after laparoscopic surgery
By Yu Yu
Laparoscopic surgery is considered a routine way to diagnose and remove endometriosis. The primary concern with laparoscopic surgery is the recurrence of endometriosis because of incomplete lesion excision. Hence, the challenge is to decrease endometriosis recurrence rate. Gonadotrophin-releasing hormone agonist…
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By Kasthuri NairThe Benefits of Vaginal Administration of Drugs
By Kasthuri Nair
There are numerous methods of drug administration used by healthcare providers today. Buggio and colleagues suggest the vagina as another avenue for delivery. They recently published a paper titled "Per vaginam" topical use of hormonal drugs in women with symptomatic…
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Dienogest for endometriosis pain in clinical practice
By Yu Yu
Dienogest is a synthetic progestogen that has been marketed as a medical treatment for endometriosis. Previous randomized controlled clinical trials have shown that it is effective in women with endometriosis at different stages of the disease. Given its recent introduction,…
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A Cholesterol-Lowering Drug and an Anticancer Drug May Be Alternative Treatments Against Endometriosis
By Özge Özkaya
Crestor (rosuvastatin), a cholesterol lowering drug and Avastin (bevacizumab), an anticancer drug are more efficient in reducing endometriosis in rats compared to progesterone medication, according to a study published in the journal Gynecological Endocrinology. For the study, researchers led by…
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