May it be a new non-hormonal treatment option for endometriosis patients?
Heidi Ledford published a news in Nature, entitled “How understudied endometriosis causes pain for hundreds of millions of women”. She aimed to summarize the recent status about endometriosis treatment options. Pain-sensing nerves and immune cells interact to worsen both pain…
Key Points Lay SummaryAn observational study on predicting endometriosis recurrence risk.
Endometriosis presents in various ways, and improper management can lead to recurrence. Studies show that the recurrence rate can range from 6% to 67%. Factors that may increase this risk include having severe or deep forms of the disease, being…
Key Points Lay SummaryStudy Sheds Light on the Molecular Mechanism of Endometriosis Lesion Formation
The production of a protein called Nucleotide-binding Oligomerization Domain 1 (NOD1) in ectopic mesenchymal stem cells may be associated with the formation of ectopic endometrial lesions, according to a new study published in the International Journal of Stem Cells. This…
Key Points Lay SummaryAnalysis of steroid hormone receptors in endometriotic tissues reveals chaotic results
A group of researchers from academic institutions located at Australia and New Zeland, led by Dr. Holdsworth-Carson, have published their recent findings on steroid receptors in peritoneal endometriosis lesions by immunohistochemistry, in the journal Reproduvtive Biomedicine Online. Endometriosis is…
Key Points Lay SummaryPotential New Approach to Treat Endometriosis
Inhibiting ribosome biogenesis could be a potential therapeutic approach for endometriosis according to a new study published in the scientific journal Biomedicines. Ribosome biogenesis plays a key role in protein homeostasis during cell growth and division. Previous research has shown…
Key Points Lay SummaryDiaphragmatic endometriosis
Diaphragmatic endometriosis is a rare clinical condition that may show signs and symptoms like chest pain, right upper quadrant abdominal pain, shoulder pain, pleuritic pain, hemothorax, pneumothorax, hemoptysis, and thoracic endometriosis syndrome while the major part of the patients is…
Key Points Lay SummaryIndocyanin Green dye for recognition of occult endometriotic lesions
The surgery for endometriosis is challenging and the resection of all lesions is not accurately related to not catching all lesions under white light (WL) conventional laparoscopy. In the study conducted by Luigi Carlo Turco et al., in a tertiary…
Key Points Lay SummaryComplex Relation Between Body mass index and endometriosis
This research aimed to find the relationship between BMI and endometriosis especially related to surgical phenotype and lesion location. An observational cohort study was led by Holdsworth-Carson et al, from Australia. The article was recently published in "RBMO" . Many earlier studies report…
Key Points Lay SummaryTargeting Endometriosis From a Different Angle
Dopamine agonists could help reduce the size of endometriosis lesions and minimize pain, while maintaining ovulation, according to a new study published in the scientific journal Human Reproduction. This constitutes a completely different approach in targeting endometriosis according to Dr.…
Key Points Lay SummaryCabergoline or Progesterone not Effective in Rat Model of Endometriosis
Oral treatment with cabergoline or micronized progesterone for four weeks is not effective in the regression of endometriotic implants in a rat model of the disease. This is according to a study published in the "Journal of Investigative Surgery". Cabergoline…
Key Points Lay SummaryTransvaginal sonography for predicting the distance between rectosigmoid endometriosis and the anal verge
For optimal surgery, pre-surgical assessment of the distance between rectosigmoid deep endometriosis lesions and the anal verge (Lesion to Anal Verge Distance-LAVD) is recommended by many specialists. A group of researchers from Norway, Austria, and Australia studied the accuracy of…
Key Points Lay SummaryIL-33 Polarize Peritoneal Macrophages for Endometriosis Growth
M2 type macrophages are the most common type of macrophages found in endometriosis and they enhance the development of endometriosis lesions. The key factors that stimulate macrophages to polarize towards M2 and contribute to the increased endometriosis lesions remain to be…
Key Points Lay SummaryDoes Getting Pregnant Really Help When You Have Endometriosis?
Pregnancy has a favorable impact on the volume of deep infiltrating endometriosis lesions according to a study published in the scientific journal "PLoS One". This is the first study that demonstrates such a favorable impact of pregnancy on endometriosis lesion…
Key Points Lay SummaryWhich cell defines endometriosis?
A well-accepted theory regarding the pathogenesis of endometriosis hypothesizes that the origin of endometriosis is from peritoneal dissemination of endometrial cells and stroma during the neonatal period or menarche. Varying cellular components of endometriosis have been observed in the setting…
Key Points Lay SummaryUltrasound-guided High-intensity Focused Ultrasound can Treat Abdominal Wall Endometriosis
Endometriosis is a painful and complicated disease that can manifest in various ways. One particular way is Abdominal Wall Endometriosis (AWE), which usually arises from surgery. As is true for other types of endometriosis, there has yet to be a…
Key Points Lay SummaryDetection of Uterine Malformations and its Link to Endometriosis
Dr. Abd El Fattah recently published a research article titled “Uterine Cavity Abnormalities in Patients with Endometriosis in Alexandria: A Diagnostic Test Accuracy Study” in Obstetrics and Gynecology International that delineated and presented the results of his study. The study has two…
Key Points Lay SummaryCombination Therapy Proves More Efficient in the Treatment of Endometriosis
In their recent paper in British Journal of Pharmacology, entitled “Combination therapy with telmisartan and parecoxib induces regression of endometriotic lesions,” Nenicu et al. illustrate the increased effectiveness of telmisartan used along with a cyclooxygenase-2 (COX-2) inhibitor (a non-steroidal anti-inflammatory…
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