By Hale Goksever CelikThe enhanced invasiveness, migration and the development of adenomyosis: Importance of M2 macrophages
By Hale Goksever Celik
Adenomyosis is the ectopic presence of endometrial stromal and glandular cells inside the myometrial tissue. Adenomyosis is diagnosed in women with gynecological problems with an incidence of 20%, although it is encountered much more frequently in hysterectomy specimens. Among many…
Key Points Lay Summary
By Özge ÖzkayaResearch Identifies Blood Proteins Associated With Endometriosis in Adolescents
By Özge Özkaya
Proteins related to angiogenesis or the formation of new blood vessels and cellular migration are enriched and more active in the blood of adolescents with endometriosis compared to healthy controls. These are the findings of a new study published in…
Key Points Lay Summary
By Nasuhi Engin AydinOxygen deprivation (hypoxia) has a critical role in the pathogenesis and progression of endometriosis
By Nasuhi Engin Aydin
Dr. Wan-Ning Li and associates from academic institutions from Taiwan have published their review paper on the role of hypoxia and possible therapeutic outcomes in the medical journal named "Reproduction" recently. Endometriosis is an important ailment with huge medical and social…
Key Points Lay Summary
A new Marker to Detect Endometriosis and Its Severity?
By Özge Özkaya
Macrophage migration inhibitory factor (MIF) could be a novel marker that could help diagnose endometriosis as well as to detect its severity. This is according to a new study by researchers in Egypt, published in the scientific journal "BMC Women’s Health".…
Key Points Lay Summary
By Dr. Youngran ParkOsteopontin and Endometriosis
By Dr. Youngran Park
Although characterized as a benign disease, some properties of endometriosis mimic malignant tissues such as proliferation, cell invasion, and metastasis. Osteopontin, also called secreted phosphoprotein 1, is one of the important molecular targets in cancer progression and metastasis. Osteopontin has been…
Key Points Lay Summary
By Yu YuEndometriotic mesenchymal stem cells may promote endometriosis
By Yu Yu
The cause of endometriosis is still debatable. Many researchers have accepted that retrograde menstruation, where the endometrial fragments released during menstruation attach and colonize the ectopic locations, is the most plausible reason. However, the numbers just do not add up.…
Key Points Lay Summary
Race, socioeconomic status, and health
By Dr. Youngran Park
Racial disparities in health have been long noted in the United States. The differences in socioeconomic status across racial groups are a major contributor to racial disparities in health. However, race reflects multiple dimensions of social inequality. Understanding and effectively…
Key Points Lay Summary
Early Developmental Gene May Play a Role in Endometriosis
By Özge Özkaya
An early developmental gene called twist may encourage the connective tissue cells of the lining of the uterus to change from being epithelial to being mesenchymal, so-called epithelial to mesenchymal transition (EMT). Mesenchymal cells play important roles in biological processes…
Key Points Lay Summary
Study Sheds Light on the Molecular Mechanism of Endometriosis Development
By Özge Özkaya
A protein called transforming growth factor-beta1 (TGF-B1) enhances the capacity of endometriotic cells or cells that make up the lining of the uterus to migrate, invade, and colonize other areas in the body. This is according to a study published…
Key Points Lay Summary
Conservative Surgery May Be Sufficient to Halt the Development of Deep Endometriosis
By Özge Özkaya
Deep endometriosis develops as a result of collective cell migration and nerve recruitment from surrounding organs, suggests a study published in the scientific journal Fertility and Sterility. Collective cell migration is the biological process whereby a group of cells moves…
Key Points Lay Summary
Programmed cell death 4 suppresses endometriosis by inhibiting autophagy and NF-κB/MMP2/MMP9 signal pathway
By Dr. Youngran Park
Endometriosis is a kind of benign disease but shares many similar features with cancers, such as abnormal cell migration, invasion, and unrestrained growth. It has been known that some genes are expressed differentially in eutopic endometrium of EM patients compared…
Key Points Lay Summary
A Better Way to Diagnose Endometriosis?
By Özge Özkaya
Three proteins found in the blood and endometrial tissues could be used to determine the stage of endometriosis and the severity of painful periods according to a study published in the journal Current Medical Science. Evaluating the levels of these…
Key Points Lay Summary
Could the Sleep Hormone Treat Endometriosis?
By Özge Özkaya
Melatonin blocks cell proliferation, invasion, and migration in both normal and endometriotic epithelial cells, according to a study published in the scientific journal Reproductive Biology and Endocrinology. Melatonin could, therefore, be a potential treatment for endometriosis The formation and progression…
Key Points Lay Summary
By Demet Candaş GreenA key cytokine in endometriosis can be targeted for endometriosis treatment
By Demet Candaş Green
Immune system dysfunction has been implicated in the development of endometriosis. One study showed that 95% of cells found in the peritoneal fluid of women with endometriosis are macrophages with impaired phagocytic function, which are unable to eat away unwanted…
Key Points Lay Summary
By Kasthuri NairAn Antagonist for Endometriosis Disease Progression: LINC00261
By Kasthuri Nair
The molecular mechanisms surrounding endometriosis remain elusive to this day. Sha et al. from Wenzhou Medical University, China, reported that LINC00261, a long non-coding RNA, may play a substantial role in inhibiting the pathogenesis of this painful illness. Their paper…
Key Points Lay Summary
Ping-Chong-Jiang-Ni Formula: A Natural Treatment
By Kasthuri Nair
In the world of modern medicine, natural and herbal remedies are often under utilized. Liang et al. recently published an article in Evidence-Based Complementary and Alternative Medicine where they explored the benefits of using a Chinese Herbal Medicine to treat…
Key Points Lay Summary