By Selma OransaySurgery for Deep Endometriosis: Reproductive Outcomes in Infertile Women
By Selma Oransay
Deep endometriosis (DE) is a severe form of endometriosis where endometriotic growths invade deeper tissues such as the pelvic organs, including the bowel, bladder, and sometimes nerves. This type of endometriosis is often linked to infertility, but the exact relationship…
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By Hale Goksever CelikLifestyle and Environmental Factors in Endometriosis: Current Insights and Future Directions
By Hale Goksever Celik
Endometriosis-associated symptoms such as dysmenorrhea, dyspareunia, chronic pelvic pain have an effect to diminish the quality of life. The physical and mental quality of life of these women is adversely affected. There are several studies evaluating the quality of life…
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Why we should prefer nerve-sparing surgery in deep endometriosis?
By Selma Oransay
Despite its benign nature, deep endometriosis can mimic malignant processes and infiltrate multiple organs, blood vessels, ligaments, and nerves within the pelvis. When conservative medical management fails, the need for surgical excision of endometriotic lesions arises. The surgeons aim to…
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Postoperative pain-related quality of life for patiens with different types of endometriosis surgery.
By Selma Oransay
Endometriosis surgery usually improves chronic pelvic pain and the quality of life in women suffering from that disease. Response to surgery depends on several factors, however, in younger ages, recurrence of both pain and endometriosis lesions are reported. Most research…
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By Özge ÖzkayaStudy Identifies Best Questionnaires to Assess Sexual Function in Patients With Endometriosis
By Özge Özkaya
The Female Sexual Function Index (FSFI) and the Sexual Activity Questionnaire (SAQ) have the best measurement properties according to the Consensus-Based Standards for the Selection of Health Measurement Instruments (COSMIN) criteria for the measurement of sexual function in women with endometriosis,…
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Management of uterine adenomyomas with percutaneous cryoablation.
By Selma Oransay
Adenomyosis can negatively affect the quality of life by causing abnormal bleeding, pelvic pain, dysmenorrhea, and dyspareunia. It is often associated with endometriomas and/or leiomyomas. Treatment of the disease differs as conservative or radical, as well as pharmacological or surgical. For…
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Spontaneous Conception After Deep Endometriosis Surgery
By Selma Oransay
Deep endometriosis is a severe form of endometriosis where lesions invade deeper than 5 mm into subperitoneal space. Surgical management of the disease is a challenging task requiring a multi-disciplinary approach and significant expertise in the field. Anastomotic leaks, fistula,…
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Pregnancy outcomes of women with endometriosis/adenomyosis.
By Selma Oransay
Endometriosis and adenomyosis are diseases presented by ectopic growth of endometrial-gland-like tissues, which we can find in ovaries, pelvic organs, and myometrium. These diseases are causes of hypermenorrhea, dysmenorrhea, chronic pelvic pain, and infertility. Although the number of reports about…
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Deep infiltrating endometriosis and postoperative pregnancy outcomes
By Selma Oransay
Although the current ESHRE guidelines state that there is no strong evidence to support surgical intervention to improve the spontaneous pregnancy rate in women with deep infiltrating endometriosis and advise Assisted reproduction technology irrespective of the severity of endometriosis, several studies…
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Endometrioma surgery and the ovarian reserve
By Selma Oransay
Traditionally, cystectomy is the gold standard for surgical approach owing to the reduced risk of recurrence. Still, it may lead to a reduction in postoperative ovarian volume and can be a cause of ovarian failure. The recent conservative surgical management of…
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Women With Endometriosis at a Higher Risk of Pregnancy Complications
By Özge Özkaya
Apart from having difficulties conceiving, women with endometriosis also seem to have a significantly higher risk of adverse pregnancy outcomes. This is according to a new population-based study published in the Journal of Clinical Medicine. It is already known that…
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Outcomes of improving chronic pelvic pain with "immersive digital therapeutics" at home.
By Selma Oransay
Studies have shown that virtual reality can effectively treat acute pain experienced by burn victims, during labor, dental surgery, or for chronic musculoskeletal, neuropathic, and cancer pain. Considering the effectiveness of treating chronic pelvic pain at home, Merlot et al.…
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Comparison of two surgical approaches for endometriosis.
By Selma Oransay
Endometriosis is one of the causes of infertility in women. But the pathophysiology of infertility caused by endometriosis is not yet clear. Hormonal disorders, abnormal peritoneal function, distorted pelvic anatomy, and multiple cesarean deliveries are among the accused. Dr. Li…
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How Good is Ultra-Long GnRH-a Treatment Before IVF for Women With Endometriosis?
By Özge Özkaya
Pretreatment with ultra-long gonadotropin-releasing hormone agonist (GnRH-a), i.e. for at least three months before in vitro fertilization (IVF), has an adverse effect on patient pregnancy outcomes with endometriosis, according to a meta-analysis of the literature published in the Journal of…
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The optimal endometrial preparation protocol in FET cycles of women with endometriosis.
By Selma Oransay
Endometriosis can create infertility and may require treatment with assisted reproductive technology (ART) to induce pregnancy. However, the current literature rarely discusses the optimal endometrial preparation protocol in thawed-frozen embryo transfer (FET) cycles for endometriotic patients. Dr.Jin. group from the Reproductive…
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Obstetric Outcomes of Pre-pregnancy Endometriosis Surgery
By Selma Oransay
Endometriosis may be associated with poor pregnancy outcomes, including placenta praevia, preterm birth, premature prelabour rupture of membranes, obstetric hemorrhage, gestational hypertensive disorders, fetal growth restriction, and perinatal death. Some authors have attempted to demonstrate a causal relationship between endometriosis…
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Does endometrioma size have an effect on IVF/ICSI outcomes?
By Hale Goksever Celik
Assisted reproductive technologies including IVF/ICSI can be suggested as the therapeutic option in women with endometriosis-associated infertility. In literature, there is a controversy regarding the influence of endometrioma size on IVF/ICSI outcomes. The group led by Drs Chapron and Santoulli…
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Does the timing of endometriosis diagnosis affect optimal infertility treatment?
By Selma Oransay
Based on a retrospective population-linked data study in "Human Reproduction", the ESHRE journal club featured a detailed discussion with 50 participants, patients’ representatives, and experts (Paola Vigano´, Mathew Leonardi, Thomas D’Hooghe, Louise Hull), together with the authors of the original article, mainly…
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The effect of chronic endometritis on pregnancy outcomes in infertile women having minimal/mild endometriosis
By Hale Goksever Celik
Endometriosis is an estrogen-dependent disease that is frequently diagnosed in reproductive-aged women. Infertility can be associated with endometriosis in these women depending on several pathophysiologic mechanisms such as anatomic distortion, and implantation failure. Thus pregnancy rate is so important, especially…
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Chronic pelvic pain and endometriosis
By Selma Oransay
Patients may have an average of 7 clinical visits before being diagnosed with endometriosis. Understanding chronic pain conditions including endometriosis-associated pain, and developing chronic pelvic pain benefits the management of the patients. The role of central sensitization, comorbid conditions, and…
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Social media and endometriosis management
By Selma Oransay
Endometriosis has a negative impact on social life, work, daily activities, personal relationship, and overall quality of life. A study from Australia recently published in the Australian New Zeland Journal of Obstetrics and Gynaecology reports that social media helps these…
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Evaluation of daily diary for endometriosis-related pain.
By Selma Oransay
Some endometriosis patient-reported outcomes elements have been previously developed in accordance with regulatory and best practice guidelines including Endometriosis Pain Daily Diary, the Endometriosis Symptom Diary, and Endometriosis Impact Scale. The aim of this study was to develop another content-valid…
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Placenta praevia and cesarean section more common in patients with ART for Endometriosis
By Hale Goksever Celik
Even though endometriosis is known to be associated with infertility, these women still have a chance to get pregnant spontaneously or by assisted reproduction techniques (ART) with the aid of recent technological developments. A It has also been shown that…
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Evaluation of patient self-reported outcome measures for endometriosis.
By Selma Oransay
Endometriosis symptomology is multifactorial and it changes over time based on the patient's life experience, perceptions, and medical treatment. These changes require the agility of adaptation for both clinicians and patients to respond properly. The documentation of the patient's specific…
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How does adenomyosis affect IVF outcomes?
By Hale Goksever Celik
Adenomyosis is defined as the localization of endometrial tissue in the muscle layer of uterus. Several theories have been proposed to explain the reasons of adenomyosis-associated infertility including uterine dysperistalsis, abnormal transportation of sperm in the uterine cavity, and embryo…
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Impact of surgery before IVF in infertile women with endometrioma
By Hale Goksever Celik
Among the women with endometriosis, 30 to 50% are estimated to have infertility. On the contrary, among women who present with infertility, 25 to 50% are estimated to also have endometriosis. Several mechanisms have been proposed to explain the association…
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By Nasuhi Engin AydinEndometrioma post-surgical-recurrence risk factors
By Nasuhi Engin Aydin
Jiang and associates from Dailan Medical University, China published their review manuscript “Risk factors for ovarian endometrioma recurrence following surgical excision: a systematic review and meta‑analysis” in the June 2021 issue of "Archives of Gynecology and Obstetrics". The most common form of endometriosis, "ovarian…
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Adenomyosis, fertility, and obstetric outcomes
By Hale Goksever Celik
Adenomyosis is the localization of endometrial glandular and stromal cells within the myometrial wall. Although magnetic resonance imaging has a higher ability to discriminate and identify adenomyosis, transvaginal ultrasonography is a cheaper, more accessible, and practical method in daily clinical practice for…
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Analyses of the main classification systems of endometriosis in terms of utrasound, MRI and surgery
By Selma Oransay
Several classifications made by gynecologists, image readers, and radiologists lead to confusion while describing the situation and estimating the progress of endometriosis. Daniela Fischerova team from the Charles University of Prague, Czech Republic, analyzed the main classifications of endometriosis in three…
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By Bahar YukselPredictors for achieving pregnancy in patients with adenomyosis and endometriosis
By Bahar Yuksel
Adenomyosis and endometriosis are benign conditions, however, both situations are associated with deterioration of life quality, a requirement of hospital administrations, and infertility. Laparoscopic surgery is the main treatment option especially for women who desire pregnancy. Shi and colleagues aimed…
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Outcomes of chronic pelvic pain of endometriosis after laparoscopic surgery
By Selma Oransay
The prevalence of endometriosis is up to 35-50% among patients with pelvic pain. Among several medical and surgical options to relieve chronic pelvic pain, surgical options are the preferred method but this depends on patients' age, fertility desire, and disease…
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Self-management and the quality of life in women with endometriosis
By Hale Goksever Celik
Endometriosis symptoms can range from mild to severe. The most common presenting complaints are mainly pelvic pain and infertility. There is no doubt that the physical and mental quality of life of these women is adversely affected. There are several studies…
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Reduced risk of "small for gestational age baby" following frozen embryo transfer in endometriosis patients
By Hale Goksever Celik
Infertility is encountered frequently in patients with endometriosis. These women could be managed using assisted reproductive technology (ART) including in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) to achieve pregnancy. However, some adverse obstetric and perinatal outcomes are experienced more…
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The more than expected prevalence of endometriosis in patients with Mullerian abnormalities
By Bahar Yuksel
Congenital müllerian anomalies resulting in a spectrum of uterine abnormalities are caused by the abnormal embryologic fusion of the müllerian ducts to form a normal uterine cavity. They are often unrecognized because they are usually asymptomatic. The presence of a uterine…
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Maternal body mass index and neonatal outcomes in women with endometriosis
By Hale Goksever Celik
Endometriosis is defined as the localization of endometrial glandular and stromal-like tissue outside the uterine cavity. Its prevalence is 10-15% in the general population of this age. However, endometriosis is diagnosed more frequently in infertile women with a prevalence of…
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The role of microbiota in the etiopathogenesis of endometriosis
By Hale Goksever Celik
Endometriosis is an estrogen-dependent disease that is commonly diagnosed in reproductive-aged women. Although many advanced types of research about the etiology, differential diagnosis and treatment have been performed, it still remains an enigmatic disease. Dr. Bedaiwy, a scientist and physician…
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The association between endometriosis and ectopic pregnancy
By Hale Goksever Celik
Endometriosis is a chronic inflammatory disease with a broad spectrum of symptoms such as dysmenorrhea, dyspareunia, chronic pelvic pain and fertility problems. It has been understood in the light of scientific evidence that endometriosis is also associated with other poor…
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Risk of placenta previa is elevated in endometriotic women who underwent surgery.
By Selma Oransay
In the last decade concerns raised for surgical operations performed before pregnancies of endometriotic patients due to significantly increased risk of pregnancy complications such as placenta previa, preterm birth, hypertensive disorders of pregnancy, placental abruption, postpartum hemorrhage and small baby…
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Serum anti-Müllerian hormone levels for predicting spontaneous pregnancy after endometriosis surgery
By Hale Goksever Celik
Endometriosis is a disease defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. Although there are several medical and surgical therapeutic options, the most effective treatment modality has not yet been elucidated. The main…
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The coexistence deep infiltrating endometriosis and fibromyalgia
By Hale Goksever Celik
Endometriosis is defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. The main symptoms of endometriosis which are dysmenorrhea, dyspareunia, and chronic pelvic pain impair the quality of life of these women. This disease may…
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The miscarriage rate in women with endometriosis undergoing IVF fresh cycles
By Hale Goksever Celik
Endometriosis is a chronic estrogen-dependent disease diagnosed in 25-40% of women with infertility. There are several mechanisms explaining the negative impacts of endometriosis on fertility through the entire reproductive process such as sperm-oocyte interaction, ovarian reserve, and implantation. Endometriosis is…
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Best endometriosis articles of the past year.
By Selma Oransay
Dr.Stowall, from the Department of Obstetrics and Gynecology of Methodist Hospital, Dallas, Texas, USA penned this letter and recently published it in the Journal of Obstetrics and Gynecology to show his remarks of importance on four best publications of the…
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Maternal and fetal outcomes in women with endometriosis : A review and meta-analysis
By Selma Oransay
Lalani et al from Dept. of Obstet. and Gynecol. , University of Ottowa, Canada, recently published this systemic review and meta-analysis of observational studies in the Journal of Human Reproduction, aimed to present the difference in the maternal and fetal…
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The vaginal delivery rate of singleton term pregnancies still remains the same after total deep infiltrating endometrosis excisions
By Selma Oransay
This recently published report in the Journal of Fertility Sterility is planned as a matched case-control study, by Nirgianakanis et al. from the University of Bern, Switzerland. Authors claimed their study is the first because previous studies on pregnancy outcome after laparoscopic…
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By Deniz KocasComparing opioid and nonopioid therapy for chronic pain
By Deniz Kocas
Over the last few decades, North-America and Europe show continued increase in prescription rates of opioids. Evidence shows significant pain reduction with opioids in the short term compared to placebo, however whether opioids are superior to non-opioids even in the…
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By Kasthuri NairEffectiveness of the Endometriosis Symptom Diary
By Kasthuri Nair
Seitz et al., a research group from Bayer AG and the University of Giessen, recently published an article titled “Patterns of missing data in the use of the endometriosis symptom diary” in BMC Women's Health. The authors were analyzing data…
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"New Pain Dairy" Could Help Better Evaluate the Impact of Endometriosis on Women’s Daily Lives
By Özge Özkaya
Researchers developed a new patient-reported endometriosis pain daily diary. The diary can help evaluate endometriosis-related pain and the impacts this can have on patients' lives as well as be used in clinical trials to assess patients’ response to treatment. “The…
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By Yu YuCohort study on outcomes of laparoscopic endometriosis surgery
By Yu Yu
Laparoscopic surgery followed by histological confirmation is considered a standard for diagnosis, staging, and treatment of endometriosis. Radical and conservative surgical approaches are often required for the removal of endometriotic lesions in the case of vaginal or rectal wall deep…
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