By Özge ÖzkayaOvarian Endometrioma Does Not Affect Egg Quality, Study Suggests
By Özge Özkaya
Ovarian endometrioma could decrease oocyte yield in patients undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI), according to a new literature review and meta-analysis published in the scientific journal Reproductive BioMedicine Online. However, it does not seem to…
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Long-term Dienogest Treatment and the Chance of Conceiving With IVF
By Özge Özkaya
It is not clear whether long-term treatment with dienogest before in vitro fertilization (IVF) affects pregnancy and live birth rates in women with endometriosis, according to a new study published in the Journal of Obstetrics and Gynaecology Canada. “Given limited…
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Can Endometriosis Affect the Chance of Giving Birth to a Live Baby?
By Özge Özkaya
Deep infiltrating endometriosis and/or endometrioma diagnosed by transvaginal ultrasound is associated with a lower chance of giving birth to a live baby in patients undergoing their first in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI), according to a new…
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Should I Have Endometriosis Surgery Before IVF-ICSI?
By Özge Özkaya
The live birth rate per in vitro fertilization (IVF) or intrauterine sperm injection (ICSI) cycle was significantly reduced in women who underwent surgery to treat endometriosis before the procedures, found a new study published in the scientific journal Reproductive Sciences. “These…
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By Selma OransayEmbryo Morphokinetics of Endometriotic Patients by Time Lapse Monitoring
By Selma Oransay
Many studies showed adverse effects of endometriosis on oocyte quality due to increased apoptosis and dysregulation of molecular pathways related to the development and growth of granulosa cells resulting on developmental arrest in embryos of women with endometriosis. Time-lapse monitoring…
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By Eylül GÜNAssessing endometrial receptivity using menstrual blood samples in patients undergoing in-vitro fertilization
By Eylül GÜN
Endometrial receptivity is the endometrium's capacity to allow the embryo the chance to adhere, infiltrate, and develop while ensuring an ideal microenvironment. When impaired, it is one of the two major factors contributing to infertility along with embryo quality by…
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By Hale Goksever CelikModerate-to-severe Endometriosis and "The Cumulative live birth rate" in IVF Cycles
By Hale Goksever Celik
Infertility is one of the major symptoms in women with endometriosis. The incidence of endometriosis is approximately 10% in reproductive-aged women and up to 40-50% in infertile women. There are multifactorial mechanisms resulting in endometriosis-associated infertility such as anatomic distortion, impaired…
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By Bahar YukselAutoimmune Disorders in Women with Endometriosis May Impair Embryo Implantation
By Bahar Yuksel
The retrospective study by Noemi Salmeri reports the effect of concomitant autoimmune disorders on the ability of the endometrium to support embryo implantation in women with endometriosis who underwent assisted reproductive technology (ART) treatments. The study involved 600 women with…
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The effect of glucocorticoid use on clinical pregnancy rates
By Selma Oransay
The preference to use glucocorticoids such as dexamethasone, prednisone, and methylprednisolone, along with IVF-ET cycles is due to the diminishing inflammatory response and suppressing immunity. Thus, while autoimmune diseases are suppressed with glucocorticoid administration, the success rate in the implantation…
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Pretreatment With Dienogest Does not Seem to Improve IVF Outcome in Endometriosis
By Özge Özkaya
Treatment with dienogest before in vitro fertilization does not increase the number of mature eggs or improve the rate of pregnancy or live births in women with endometriosis, found a new study published in the scientific journal Gynecologic and Obstetric…
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Which surgery for deep endometriosis? Laparoscopic shaving or rectal resection?
By Selma Oransay
This keynote lecture entitled "Deep endometriosis: The place of laparoscopic shaving" was presented by Dr. Jacques Donnez, the director of the infertility research unit at the Catholic University of Louvain, Brussels, Belgium, at the Annual International Medical Conference of the Endometriosis Foundation…
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How Good is Ultra-Long GnRH-a Treatment Before IVF for Women With Endometriosis?
By Özge Özkaya
Pretreatment with ultra-long gonadotropin-releasing hormone agonist (GnRH-a), i.e. for at least three months before in vitro fertilization (IVF), has an adverse effect on patient pregnancy outcomes with endometriosis, according to a meta-analysis of the literature published in the Journal of…
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Conventional IVF or ICSI: Which one is more accurate in endometriosis-related infertility?
By Hale Goksever Celik
Although the prevalence of endometriosis is 10-15% in the general population at reproductive age, it is diagnosed more frequently in infertile women with a prevalence of 25-40%. Although the exact mechanism explaining the association between endometriosis and infertility has not…
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Predictability of IVF success by basal progesterone levels on patients with endometriosis
By Bahar Yuksel
Endometriosis causes infertility in around 30-40% of all diagnosed women. Thus, strategies leading to more successful IVF results remain important. In the prospective study by Jovan Bila, the menstruation day 3 levels of serum progesterone were questioned to have a…
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Does endometrioma size have an effect on IVF/ICSI outcomes?
By Hale Goksever Celik
Assisted reproductive technologies including IVF/ICSI can be suggested as the therapeutic option in women with endometriosis-associated infertility. In literature, there is a controversy regarding the influence of endometrioma size on IVF/ICSI outcomes. The group led by Drs Chapron and Santoulli…
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Placenta Previa More Common Among Pregnant Women With Endometriosis
By Özge Özkaya
Endometriosis is associated with a higher risk of placenta previa, according to a new study published in the scientific journal Reproductive Sciences. This is the case whether the women became pregnant following in vitro fertilization (IVF). Moreover, for women with endometriosis…
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Ovarian Endometrioma Reduces the Chance of a Successful Pregnancy With IVF
By Özge Özkaya
Ovarian endometrioma significantly decreases ovarian reserve or the capacity of the ovaries to produce eggs that are able to be fertilized and give rise to a successful pregnancy. This is according to a study published in the scientific journal Medicine.…
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Are my Eggs Good Enough for IVF?
By Özge Özkaya
There does not seem to be any difference in the rate of live births between women with endometriosis who became pregnant following IVF using their own eggs or eggs obtained from a donor. This suggests that oocyte quality may not…
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Which Method Is Best To Reduce Pain During Egg Retrieval?
By Özge Özkaya
Women experience the least pain during egg retrieval for in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) when alfentanil is injected into the muscles and this is followed by fentanyl injection into the bloodstream and non-sedative analgesics given by…
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Shining like fireflies: a new approach to visualize early endometriosis
By Bahar Yuksel
Endometriosis is a complex and unsolved disease that requires animal studies in order to understand its nature. There are a group of animal models designed for endometriosis studies, but most require sacrificing the animal. In the experimental study designed by the team…
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Endometriosis Seems to Affect The Development of the Embryo
By Özge Özkaya
Embryos development is impaired in embryos from women with endometriosis found a new study published in the Journal of Assisted Reproduction and Genetics. In spite of this, the outcomes of in vitro fertilization (IVF) are similar for patients with endometriosis…
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Is intrauterine insemination effective in women having endometriosis-associated infertility?
By Hale Goksever Celik
The most common presenting complaints of women with endometriosis are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Affected women demand therapy for these symptoms of endometriosis, notably fertility problems. Several underlying mechanisms have been proposed to explain endometriosis-associated infertility including anatomic…
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The higher the Endometriosis Fertility Index, the higher the chance of getting pregnant
By Hale Goksever Celik
The women who desire to get pregnant may also suffer from fertility problems depending on several mechanisms such as anatomic distortion, peritoneal adhesions, tubal dysfunction, impaired quality of oocytes, and impaired endometrial receptivity. One of the most important problems in…
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The Epithelial–Mesenchymal Transition and IVF success
By Bahar Yuksel
Endometriosis is a disease with lots of unknowns and one is that the reason for causing infertility. It is possible that a decrease in mitochondrial content may diminish oocyte quality in endometriosis. Furthermore, endometriosis alters the microenvironment of maturing oocytes that…
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How does adenomyosis affect IVF outcomes?
By Hale Goksever Celik
Adenomyosis is defined as the localization of endometrial tissue in the muscle layer of uterus. Several theories have been proposed to explain the reasons of adenomyosis-associated infertility including uterine dysperistalsis, abnormal transportation of sperm in the uterine cavity, and embryo…
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Assisted Reproductive Technology Outcomes in Women with and without Endometriosis
By Selma Oransay
Endometriosis causes infertility in one-third of patients, while in approximately 25-35% of infertile women, the cause is endometriosis. The primary interest and the question of Moss et al. from the University of Queensland, Brisbane, Australia was "the differences in the…
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Adenomyosis, fertility, and obstetric outcomes
By Hale Goksever Celik
Adenomyosis is the localization of endometrial glandular and stromal cells within the myometrial wall. Although magnetic resonance imaging has a higher ability to discriminate and identify adenomyosis, transvaginal ultrasonography is a cheaper, more accessible, and practical method in daily clinical practice for…
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Ultrasonographic signs of adenomyosis, surgery and infertility in endometriosis patients
By Bahar Yuksel
Adenomyosis is simply defined as the presence of endometrial glands and stroma within the uterine myometrium and is related to severe menstrual bleeding, pain, and infertility. Previous reports demonstrated the coexisting of endometriosis and adenomyosis is common. In the present…
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By Nasuhi Engin AydinThe need for the standardization of diagnostic protocols for "adenomyosis"
By Nasuhi Engin Aydin
Dr. Squillace and associates from Brasilian Academic and Health Centers published their paper titled “Adenomyosis and in vitro fertilization impacts- a literature review” in a recent issue of "JBRA Assisted Reproduction". As common gynecological ailment adenomyosis frequently coexists with endometriosis.…
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Progestin suppression for endometriosis before IVF
By Hale Goksever Celik
“Dienogest is a suitable and safe substitute for GnRHa pretreatment in endometriosis patients”, according to the Khalifa et al., from Egypt. Endometriosis is one of the leading reasons for infertility due to decreased oocyte/embryo quality, fertilizability, tubal function, and aberrant endometrial…
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Fertilization rate and pregnancy outcome in IVF cycles of endometriosis.
By Selma Oransay
Endometriosis affects the pelvic cavity, uterus, ovaries and causes impaired fertility as a result. The chronic inflammatory nature of this disease negatively impacts the oocyte quality, maturation, and fertilization. Obviously, fewer oocytes can be harvested in the IVF cycles of…
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By Yu YuThe "metabolome" of follicular fluid in deep infiltrating endometriosis
By Yu Yu
Endometriosis encompasses three different phenotypes, being superficial endometriosis, deep infiltrating endometriosis (DIE), and ovarian endometrioma (OMA). The latter is the most severe form and has an unfavorable impact on ovarian function. Infertility associated with endometriosis has been linked to chronic…
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Egg Freezing for Endometriosis: Should she rush - Tomer Singer, MD
By Özge Özkaya
In this presentation, Dr. Tomer Singer, a fertility specialist and the medical director at Shady Grove Fertility in Manhattan, New York talks about egg freezing and its importance for women with endometriosis. He emphasizes the importance of having an endometriosis…
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Limits of endometrioma surgery in infertility patients - Liselotte Mettler, MD, PhD
By Selma Oransay
The removal of endometrioma may affect ovarian reserve because healthy follicles near endometrioma could also be excised during this procedure. Another concern about the ovarian reserve is that it may be already low before the surgery. Anti Mullerian Hormone (AMH)…
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Effect of Endometriosis on IVF Success Rates
By Özge Özkaya
Endometriosis lowers the rate of cumulative live births during in vitro fertilization (IVF). However, this is due to a lower number of embryos being available for transplantation rather than their quality. This is according to a study published in the "Journal…
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Iron overload in follicular fluid in Endometriosis
By Yu Yu
Around 20-50% of women with endometriosis have an infertility issue. Assisted reproductive technology (ART) is a common procedure to assist women with endometriosis to become pregnant. However, one major problem remains that women with endometriosis tend to have fewer oocytes…
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New Insights on Infertility and Low Success Rates of Assisted Reproduction in Women with Endometriosis
By Özge Özkaya
The fluid surrounding immature eggs waiting to mature and be fertilized by a sperm to lead to pregnancy is different in women with endometriosis compared to those without, according to a study published in Molecular Biology Reports. This could explain,…
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The predictive factors for early spontaneous miscarriage in IVF/ICSI cycles
By Hale Goksever Celik
The most common presenting complaints of endometriosis are mainly dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Affected women demand therapy for these symptoms of endometriosis, notably fertility problems. The clinical pregnancy rate has increased up to 60% in assisted reproductive…
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What we should know in managing infertility related to endometriosis?
By Nasuhi Engin Aydin
Dr. Llarena and associates made a comprehensive review of the causes of infertility in endometriosis and adverse effects of surgical procedures in Clinical Medicine Insights: Reproductive Health. Infertility is an important issue in endometriosis patients and about 30-50 % face infertility.…
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A new trial to reduce the failure of IVF/ICS protocols in severe endometriosis
By Selma Oransay
Kong et al., from the first affiliated hospital of Zhengzhou University, China, recently published this single-blinded, a multicentered and randomized controlled study in the Journal of Reproductive Health, with the aim to find a safer and more effective ovulation induction regimen for patients with…
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Ovarian stimulation regimes: Concerns on progression or recurrence of endometriosis
By Selma Oransay
Somigliana et al., from the University of Milan, Italy, performed a literature review to predict the endometriosis-enhancing effect of ART regimes on infertile women and reported their results in Reproductive Biomedicine Online. Their points of interest were increasing dysmenorrhea, dyspareunia, non-menstrual pain and…
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The miscarriage rate in women with endometriosis undergoing IVF fresh cycles
By Hale Goksever Celik
Endometriosis is a chronic estrogen-dependent disease diagnosed in 25-40% of women with infertility. There are several mechanisms explaining the negative impacts of endometriosis on fertility through the entire reproductive process such as sperm-oocyte interaction, ovarian reserve, and implantation. Endometriosis is…
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Which comes first in endometriosis management: In vitro fertilization or surgery?
By Hale Goksever Celik
Endometriosis is defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity. The prevalence is found to be 7%–10%, but among infertile women, it increases up to 50%. Early diagnosis and personalized management are important to…
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By Dr. Youngran ParkEndometrioma, Fertility, and Assisted Reproduction
By Dr. Youngran Park
Endometriosis can negatively impact a woman’s health and quality of life. Surgery has been considered the primary treatment to overcome infertility in cases of ovarian endometrioma. Patients struggling with endometriosis often pursue assisted reproductive technologies (ART) due to fertility issues.…
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By Murat OsmanHow Ovarian Endometriomas and DIE affect ART outcomes
By Murat Osman
Previous studies have evaluated the impact of an ovarian endometrioma on ovarian reserve and its impact on the success of assisted reproductive technology (ART) outcomes have controversial results. ART is a method by which a woman’s own hormones are used…
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IVF Is the Best Option to Become Pregnant for Women with Severe Endometriosis, or Is It Not?
By Özge Özkaya
Treating rectal endometriosis with surgery seems to increase the chance of a woman conceiving, with most pregnancies occurring naturally. This is according to a study published in the medical journal Human Reproduction. The optimal treatment for women with severe endometriosis…
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Should I Have Surgery Before Trying to Conceive?
By Özge Özkaya
The presence of rectouterine nodules is associated with a lower chance of becoming pregnant with in vitro fertilization (IVF), according to a study published in the Journal of Gynecology Obstetrics and Human Reproduction. This finding is important as it can…
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Vitamin C supplementation in the patients with endometriosis undergoing in vitro fertilization-embryo transfer
By Hale Goksever Celik
Endometriosis is defined as the localization of endometrial stromal and glandular cells outside the uterine cavity. Women having endometriosis present with dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Thus, infertility remains a significant problem for women with endometriosis. Endometriosis is…
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By Kasthuri NairExtending the Female Fertility Clock
By Kasthuri Nair
Varela, Sanchez-de-Puerta, and Garcia-Velasco are a group of scientists from various institutions in Spain and they recently published a review article titled “Fertility, IVF and reproductive genetics” in Current Opinion in Obstetrics and Gynecology. In this publication, the authors discussed…
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Increasing IVF Success Rates
By Özge Özkaya
DuoStim or double ovarian stimulation is the most promising approach to increase the number of eggs collected to be used in IVF, according to a review article published in the journal Current Opinion in Obstetrics and Gynecology. Pain and infertility…
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Another Marker to Predict the Outcome of IVF for Women with Endometriosis
By Özge Özkaya
AOPPs or advanced oxidative protein products may be new markers to predict egg quality and the outcomes of IVF in infertile women with endometriosis according to a study published in the journal Experimental and Therapeutic Medicine. This finding suggests that anti-oxidative treatments…
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Should Women with Endometriosis have IVF Treatment to Conceive Following Laparoscopic Surgery?
By Özge Özkaya
Women affected by endometriosis-associated infertility who are younger than 35, and have a good ovarian reserve and a partner with normal semen parameters can benefit from a so-called integrated approach for the management of their infertility, according to a study published…
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By Demet Candaş GreenBody Mass Index and IVF outcomes in non-obese endometriosis patients
By Demet Candaş Green
Endometriosis and body mass index (BMI) are inversely related, meaning obese women are at a lower risk of developing endometriosis. Similarly, women with lower BMI are considered high risk for severe types of endometriosis. The severity of endometriosis brings about…
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Treatment of minimal endometriosis in infertile women
By Demet Candaş Green
For women with mild/minimal endometriosis, European Society of Human Reproduction and Embryology (ESHRE) recommends the removal of endometriotic lesions to improve fertility and increase pregnancy rates. For women undergoing assisted reproductive treatment, there is ongoing debate whether surgical removal of…
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EFA.MC.2017.“The Abnormal Embryos That Aren’t”,“Tens of thousands of women thought they couldn't have babies: But what if they could.”Dr. Norbert Gleicher Dr. Monica Halem
By Özge Özkaya
The presentation started with the story of Monica Halem who had endometriosis and had been trying to conceive using in vitro fertilization VF), but was told that none of her fertilized embryos would be viable based on pre-implantation genetic screening…
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Is operation the best option for infertile patients with digestive endometriosis?
By Demet Candaş Green
A severe form of endometriosis affecting 8-12% of women with deep endometriosis is bowel endometriosis. Bowel involvement with associated infertility is a serious challenge for gynecologists who must choose between two main therapeutic options: surgery or medically assisted procreation (e.g.…
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Swimming Against the Stream: Is Surgery Worthwhile in Women with Deep Infiltrating Endometriosis and Pregnancy Intention?
By Murat Osman
Management of Deeply Infiltrating Endometriosis (DIE) is further complicated by the implications of affected patients who plan to become or are pregnant. Optimal management in this situation is not standardized due to a lack of randomized trials comparing primary surgery…
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Ovarian Reserve Depletion is not Time Sensitive
By Kasthuri Nair
The European Journal of Obstetrics & Gynecology and Reproductive Biology recently published a paper titled “Is endometrioma-associated damage to ovarian reserve progressive? Insights from IVF cycles.” This publication by Benaglia et al. examines the controversial relationship between endometriosis and ovarian…
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Updates in the Field of Endometriosis: Fertility
By Kasthuri Nair
Infertility can be a significant problem for many women who are suffering from endometriosis. In their chapter titled “Endometriosis and Fertility,” Evans and Decherney discuss the role of endometriosis in infertility and examine the usefulness of various fertility treatments. The…
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Endometriosis Fertility Index Anticipates Pregnancy in Women with Endometriosis
By Kasthuri Nair
Women are often afflicted by endometriosis during their reproductive years and can be faced with the prospect of infertility. These women also undergo treatments and procedures that can further affect their fertility. Consequently, in 2010, Adamson and Pasta came up…
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Best Time for IVF Between 7 and 25 Months Post Surgery Study Suggests
By Özge Özkaya
The more severe endometriosis is, the lower the success rate of IVF, according to a new study published in the Journal of Minimally Invasive Gynecology. However, the presence of endometriosis as such does not seem to affect the outcome of…
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Factors that Impact IVF-ICSI Outcomes of live birth
By Kasthuri Nair
Endometriosis affects women in their reproductive years, which often makes it difficult for women with this disease to reproduce. A paper published in the Journal of Assisted Reproduction and Genetics by Roux et al. from Marseille, France, addressed this issue…
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Endometrial Receptivity and Infertility
By Kasthuri Nair
A study entitled “Endometrial receptivity in eutopic endometrium in patients with endometriosis: it is not affected, and let me show you why” was recently published in Fertility and Sterility explored the relationship between endometriosis and infertility. This study conducted by Miravet-Valenciano et al.…
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ICSI Outcomes for Laparoscopic Intervention of Endometriosis
By Kasthuri Nair
Women with endometriosis can have trouble conceiving and often turn to fertility treatments for help. Guler et al. recently published a paper in Systems Biology in Reproductive Medicine titled “The Impact of laparoscopic surgery of peritoneal endometriosis and endometrioma on…
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Retinoic Acid Signaling Involved in Endometrial Decidualization
By Murat Osman
Decidualization occurs in the eutopic endometrium during the luteal phase and is controlled by signaling pathways such as cyclic adenosine monophosphate (cAMP) and progesterone. Researchers from the Northwestern University School of Medicine reported in their recent paper entitled "Altered Retinoid…
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Pregnancy Risks Associated with Severe Endometriosis
By Kasthuri Nair
Living with endometriosis can be painful and challenging; however, the challenges increase for women that are pregnant and have this disease. Recently, BJOG published an article titled “The ominous association between severe endometriosis, in-vitro fertilization, and placenta praevia: Raising awareness,…
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Deep Infiltrating Endometriosis, Surgery and Fertility
By Kasthuri Nair
Carneiro, Costa, and Ávila recently published an article in a scientific journal named Reproduction, titled “To operate or not to operate on women with deep infiltrating endometriosis (DIE) before in vitro fertilization (IVF),” that explored the relationship between DIE and infertility.…
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Asian Women at Higher Risk of Endometriosis and Less Likely to Conceive with IVF but not Because of their Endometriosis
By Özge Özkaya
The rate of endometriosis is higher amongst women of Asian origin confirms a study published in the Journal of Assisted Reproduction and Genetics. In addition, pregnancy rates following fertility treatments are lower in this group of women. However, this does…
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Endometriosis Reduces Chance of Having a Baby Even with Assisted Reproduction, Study Shows
By Özge Özkaya
Endometriosis significantly decreases the likelihood of conceiving even with assisted reproductive technique such as in vitro fertilization (IVF) and Intracytoplasmic sperm injection (ICSI), according to a study published in the European Journal of Obstetrics & Gynecology and Reproductive Biology. In…
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