By Eylül GÜNUnraveling the Immune System's Role in Endometriosis
By Eylül GÜN
Endometriosis is often driven by complex immune system interactions. Dysregulated immune cells, including macrophages, neutrophils, and natural killer cells, play a significant role in promoting inflammation and lesion progression. Researchers from China Led by Dr.Xu conducted a study to investigate…
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By Hale Goksever CelikLifestyle and Environmental Factors in Endometriosis: Current Insights and Future Directions
By Hale Goksever Celik
Endometriosis-associated symptoms such as dysmenorrhea, dyspareunia, chronic pelvic pain have an effect to diminish the quality of life. The physical and mental quality of life of these women is adversely affected. There are several studies evaluating the quality of life…
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By Selma OransayRetrograde Menstruation: Insights from Humans and Non-Human Primates
By Selma Oransay
Vigano et al.from the Academic Center for Research on Adenomyosis and Endometriosis of Milan University, Italy, conducted a comprehensive literature review over a span of 23 years to evaluate retrograde menstruation in both humans and non-human primates, focusing on its role…
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Endometriosis: Investigating Theoretical Causes and Pathogenesis
By Selma Oransay
Understanding the etiology of endometriosis is crucial for preventing its occurrence and minimizing the significant health burdens it imposes on women. As current treatment options are limited and often lead to severe side effects, identifying potential causes can empower women…
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By Nasuhi Engin AydinEndometriosis and Ovarian Cancer: A Genetic Connection
By Nasuhi Engin Aydin
Academicians Zhang and Yan from Ningbo University, Zhejiang, China, have recently published a pivotal study in Scientific Reports examining the cancer risk associated with endometriosis. Endometriosis, a chronic condition affecting approximately 6–10% of women worldwide, significantly diminishes quality of life…
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By Özge ÖzkayaStudy Sheds Light on the Role of Programmed Cell Death in Endometriosis
By Özge Özkaya
Three genes, TNFSF12, AP3M1, and PDK2 could be key biomarkers of programmed cell death in endometriosis, according to a new study published in the peer-reviewed scientific journal Frontiers in Endocrinology. “These findings provide new directions for the early diagnosis and…
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Gluten-free diet fot endometriosis-associated gastrointestinal symptoms
By Hale Goksever Celik
Women with endometriosis often report gastrointestinal symptoms such as bloating, constipation, diarrhea, and abdominal cramping,may have a negative impact on women’s lives having endometriosis and which can mimic irritable bowel syndrome (IBS) leading to potential misdiagnosis. A commonly suggested dietary…
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Intrinsic Potential Factors in Retrograde Menstruation
The mechanistic model of endometriosis pathogenesis suggests that anatomical factors promoting retrograde menstruation are crucial and biologically sound. This model is supported by the strong link between obstructive Müllerian anomalies and endometriosis, indicating a causal relationship between the amount of…
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Bladder Endometriosis: Current Knowledge and Future Directions
By Selma Oransay
About 70-80% of urinary tract endometriosis occurs in the bladder, particularly affecting the base and dome regions. Endometriotic lesions can penetrate the detrusor muscle either partially or completely. Endometriosis affecting the uterovesical fold peritoneum or deep endometriosis that does not involve…
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Post Surgery Endometrioma Recurrence
By Selma Oransay
Endometrioma is a common form of endometriosis. Endometrioma cystectomy is the preferred treatment, as it is more effective than ablation or laser vaporization in reducing pain and recurrence. While medical treatment can help prevent recurrence after surgery, postoperative hormonal therapy…
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Does a comprehensive interventional program improve sexual health in women with endometriosis?
By Hale Goksever Celik
Women with endometriosis suffer from dysmenorrhea, dyspareunia and chronic pelvic pain, all of which has significant negative consequences on their physical and psychological health regarding sexual and reproductive function. A group of scientists from Iran, published a study protocol titled…
Key Points Lay Summary
GP Records May Hold Information About Possible Endometriosis in Adolescents
By Özge Özkaya
The prevalence of coded dysmenorrhoea in the records of general practitioners (GP) is significantly lower than what is suggested in community surveys, according to a new study published in the British Journal of General Practice. However, menstrual symptoms in adolescents are commonly seen…
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Menstrual Health & Endometriosis Education Increases the Awareness in Students
By Hale Goksever Celik
The main symptoms of endometriosis include dysmenorrhea, dyspareunia, and chronic pelvic pain that may result in social and developmental disturbances such as abstinence from school or work. There is a significant diagnostic delay of endometriosis diagnosis, because symptoms may be…
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Personalized Surgical Strategies for Bowel Endometriosis to Enhance Patient Outcomes
By Eylül GÜN
Bowel endometriosis often impacts the rectum or sigmoid colon, causing significant symptoms and reducing fertility. Treatments include hormonal therapy and surgery, with techniques varying widely. Crestani et al., in the leadership of Dr. Horace Roman, conducted a study aiming to…
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Robot-assisted laparoscopy for deep infiltrating endometriosis of bowel
By Selma Oransay
Deep infiltrating endometriosis is characterized by lesions larger than 5 mm that penetrate the peritoneum or invade the muscular layer of adjacent organs, affecting over 20% of women with endometriosis. Bowel involvement occurs in 5-12% of cases and may present with…
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Causal links between inflammatory regulators and endometriosis phenotypes
By Eylül GÜN
Endometriosis is believed to be polygenic and multifactorial, involving processes such as angiogenesis, immune responses, hormonal changes, and progesterone resistance. Inflammation is suspected to play a crucial role in its development, potentially creating a microenvironment that supports ectopic endometrial tissue growth.…
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A literature review about postmenopausal endometriosis.
By Selma Oransay
Typically, endometriosis disease brings relief to women after menopause, but some individuals continue to develop some endometriosis-related issues even after the cessation of menstruation. This enigmatic condition, called postmenopausal endometriosis, needs to be understood, and the disease must be diagnosed…
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Endometriosis relief: How vitamins C and E can make a difference
By Eylül GÜN
Recent studies indicate that oxidative stress significantly contributes to the onset and progression of endometriosis. High levels of reactive oxygen species (ROS) can cause cellular damage and enhance inflammation, leading to the pain associated with the condition. Antioxidants like vitamins…
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Retrograde Menstruation Theory Through Müllerian Anomalies
By Selma Oransay
The pathogenesis of endometriosis is still under debate. Sampson also described this condition as "developmentally misplaced endometrial tissue" in 1925. To evaluate the theories of pathogenesis, Vercellini et al. from the Academic Center for Research on Adenomyosis and Endometriosis at…
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Diminished physical activity in women with endometriosis due to chronic pelvic pain
By Hale Goksever Celik
Endometriosis is a systemic, chronic, inflammatory disease defined as the localization of endometrial-like tissue outside the uterine cavity. Pelvic pain is the most common symptom in these women resulting in abstinence from school or work and psychosocial problems. Physical activity…
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Postmenopausal endometriosis is often neglected
By Nasuhi Engin Aydin
Romanian academicians led by Dr. Mihai-Daniel Dinu have published their review of the published scientific data related to postmenopausal endometriosis in a recent special issue of the medical periodical Life. Even though endometriosis is accepted as a hormone-dependent disorder of…
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Study Identifies Factors Associated With the Risk of Adenomyosis Progression
By Özge Özkaya
The disease progression rate of adenomyosis at one-year follow-up is 21.3%, according to a new study published in the International Journal of Gynecology & Obstetrics. For hormonally untreated patients this rate is 30.77% while for those who were hormonally treated, it…
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Study Sheds Light on Molecular Mechanism of Endometriosis Development
By Özge Özkaya
Cell adhesion molecule 2 (CADM2) may inhibit the development of endometriosis, according to a new study published in the scientific journal Reproductive Sciences. It may do so by suppressing epithelial-to-mesenchymal transition. A better understanding of the mechanism underlying the development of…
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Any link between endometriosis and neonatal uterine bleeding?
By Selma Oransay
A Medline search using the keywords " neonatal uterine bleeding," " pathophysiology," and "premenarche" was made by Dr. Habiba et al. from the Department of Health Sciences, University of Leicester, Leicester, UK. A total of 2264 articles were collected, and…
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Endometriosis and mental health disorders: How associated are they?
By Eylül GÜN
As with any chronic condition, endometriosis does not only present with physiological problems. The association between endometriosis and mental health issues has been widely studied and it is now known that these patients undergo depression, anxiety, and even bipolar disorder…
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Dysmenorrhea in adolescent girls and the quality of life
By Hale Goksever Celik
Dysmenorrhea, also known as period pain, painful periods, or menstrual cramps, is pain during menstruation. Despite its high incidence, dysmenorrhea is often a stigmatized and normalized condition. However, it is known that painful periods cause abstinence from work or school…
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A concerning link between endometriosis and cardiovascular disease.
By Selma Oransay
Endometriosis is a disease characterized by endometrial-like tissues outside the uterus, which causes inflammation, scarring, and adhesion formation. The pathologic process of forming those adhesions releases proinflammatory molecules, cytokines, and growth factors that may have systemic effects. Recent research, for…
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Ultrasonographic findings and the clinical symptoms of pelvic endometriosis
By Selma Oransay
Imaging techniques achieve the clinical diagnosis of endometriosis, which affects 10-15% of all women of reproductive age. Suspected patients with clinical history and symptoms need a systemic examination of the uterus, ovaries, adnexa, and peritoneal covering the rectouterine, retrocervical, and…
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Women's willingness to donate menstrual blood for endometriosis research
By Selma Oransay
The menstrual blood is 50-100 ml/per cycle, with 80% lost during the first three days. On the heaviest bleeding day, 2 to 8 ml may be collected from a cup worn for four hours. This fluid could be investigated by…
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Early use of hormonal contraceptives and the probability of endometriosis diagnosis later in life
By Selma Oransay
Hormonal contraceptives are the first-line medical treatment of endometriosis. If an adolescent has chronic pelvic pain and is an "unresponder" to hormonal therapy, the likelihood of having an "endometriosis diagnosis" is higher. This sign should warn clinicians about endometriosis diagnosis…
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Inguinal endometriosis is a commonly neglected differential diagnosis
By Nasuhi Engin Aydin
A case series of inguinal endometriosis with eight patients from Tehran, Iran has appeared in a recent issue of the Journal of Medical Case Reports. It is a fact that many inguinal endometriosis cases are undiagnosed since they undergo herniorrhaphy…
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Early diagnosis of deep infiltrating endometriosis in adolescence
By Selma Oransay
Dysmenorrhea is widely observed in adolescence, and endometriosis is one of its causes. However, endometriosis diagnosis is usually made after 25 years of age. It is clear that early diagnosis and management of this progressive disease is essential and will…
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Psychological effect of endometriosis due to chronic pelvic pain
By Hale Goksever Celik
The most common symptoms of endometriosis are dysmenorrhea, dyspareunia, and chronic pelvic pain, all of which affect the quality of women’s lives. Early diagnosis and management are important as endometriosis impairs the quality of life of patients and creates a…
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Are women with endometriosis more prone to have mental health disorders?
By Hale Goksever Celik
Endometriosis is a long-term morbidity resulting in impaired physical, sexual, psychological, and social health. The most common clinical findings of endometriosis patients are chronic pelvic pain and fertility problems, associated with impaired quality of life. These women are also affected…
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Psychosocial Factors Must Be Taken Into Account When Dealing With Endometriosis
By Özge Özkaya
It is crucial to take into account both physical and psychosocial factors to maintain physical and mental health in patients with endometriosis, according to a new study published in the scientific journal Psychology & Health. “Treatment should address both pelvic…
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Complementary and alternative therapies for managing acyclic pelvic pain in women with endometriosis
By Hale Goksever Celik
The quality of life in women with endometriosis is affected depending on the symptoms and signs of endometriosis such as dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Because of different clinical spectrum and diagnostic delays, there is no optimum management…
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Risk of endometriosis and related occupational factors among working women
By Eylül GÜN
As a debilitating disease, endometriosis is well known to have effects on the patient's overall quality of life. Various studies have consistently reported that working women face an increased risk of endometriosis growth. Lee et al. from Korea conducted a…
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Peritoneal fluid in young women with endometriosis
By Selma Oransay
Many blood substances are present in peritoneal fluid due to their derivation from the transudation of blood through the peritoneal surface. Ectopic endometriotic lesions can also change the medium to contribute to the definition of the local environment of the…
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Endometriosis and the risk to have mental disorders
By Hale Goksever Celik
The most common clinical findings of endometriosis patients are pelvic pain and fertility problems, resulting in impairment of quality of life. These women are also affected regarding psychological health due to disease-associated symptoms. Dr. Wang et al., from Taiwan, published…
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A herbal product has promising results in experimental endometriosis
By Nasuhi Engin Aydin
Neroli oil (bitter orange) is a nontoxic volatile substance from the flowers of Citrus aurantium that belongs to the Rutaceae family. This oil has notable anti-inflammatory effects besides potent antioxidant activity with 100% singlet oxygen scavenging activity. Contemporary pathophysiological views…
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The effect of medical treatment on sexual function and quality of life in women with endometriosis
By Hale Goksever Celik
Women with endometriosis suffer from dysmenorrhea, dyspareunia and chronic pelvic pain, all of which has significant negative consequences on their physical and psychological health regarding sexual function, work and social relationships. Biasioli et al. from Italy, published an article entitled…
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Family history of endometriosis and its characteristics
By Selma Oransay
Depression and migraine are two familial disorders affected by menstrual cycle and endometriosis patients have an increased likelihood of suffering from these comorbidities. A correlation of endometriosis, migraine and depression has been already reporteed in the literature, however a link for…
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Study Finds Link Between Exposure to Pollutants and Increased Riks of Endometriosis
By Özge Özkaya
High concentrations of polycyclic aromatic hydrocarbons in urine may be associated with a higher risk of endometriosis, according to a new study published in the scientific journal Environmental Science and Pollution Research. The study also found that the concentration of…
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The urgent need for research and compassionate care in endometriosis
By Eylül GÜN
Endometriosis, a common yet little-known inflammatory disorder, has significant patient and public health impacts due to underinvestment in its research and care. Delayed diagnosis and inadequate care persist due to reliance on surgical methods and limited advancements in medical therapies.…
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Diagnosis and the Treatment of Postmenopausal Endometriosis
By Selma Oransay
About 190 million women around the world are diagnosed with endometriosis. The majority of the cases are between 30 and 40 years of age. After menopause, the incidence of endometriosis declines to 2-5%, and it is more common in women…
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Potential New Therapeutic Avenue for Deep Endometriosis
By Özge Özkaya
The use of lipid nanoparticles carrying methotrexate seems to be safe and feasible in women with deep infiltrating endometriosis, according to a new study published in the scientific journal Archives of Gynecology and Obstetrics. The approach could, therefore, be a new…
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Quality of life analyses among women with endometriosis
By Selma Oransay
Clinical factors that may affect the quality of life in women with endometriosis are mental health, sexual life, working capacity, and social relations. Symptom severity, especially dysmenorrhea, heavy periods, pelvic pain, and infertility complaints, are the most disturbing factors in…
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The type of surgical approach compared to complications and recurrence for colorectal endometriosis
By Hale Goksever Celik
Women with endometriosis may have extension and infiltration of the intestine, called "colorectal endometriosis, in up to 12%. The main symptoms are alterations in bowel habits, pelvic pain, and/or infertility. The gold standard management option for colorectal endometriosis is surgical…
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Reviewing all you want to know on endometriosis !
By Nasuhi Engin Aydin
Academicians from the International University of Sarajevo, Bosnia, and Lincoln Medical School, UK have written a comprehensive updated review on endometriosis covering many aspects of endometriosis and published their paper as an open-access manuscript in the journal “Pathology-Research and Practice”. …
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Hazardous substances in pollution and relationship with endometriosis.
By Selma Oransay
Vallée and colleguages. from the Department of Epidemiology and Public Health of Foch Hospital, France, recently published a narrative review about environmental pollution and its association with endometriosis in BJOG. They used the existing English literature to discuss the association…
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Clinical Trial Tested Safety of Potential New Drug to Manage Endometriosis
By Özge Özkaya
The non-peptide gonadotropin-releasing hormone antagonist SHR7280 has favorable safety, pharmacokinetics, and pharmacodynamics in 3 different doses, according to the results of a phase 1 clinical trial published in the scientific journal Clinical Pharmacokinetics. “The results of this study provide evidence to…
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By Bahar YukselEndometriosis and breast cancer- love or hate?
By Bahar Yuksel
Many studies have been conducted to investigate the relationship between endometriosis and breast cancer, but no definitive conclusion has been reached yet. In the study co-authored by Yan and Li et al, endometriosis-related GWAS data was used to determine the…
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Underestimation of Dysmenorrhea in adolescents
By Hale Goksever Celik
Women with endometriosis may suffer from painful symptoms, especially during menstruation or sexual intercourse. One of the main etiologic reasons for secondary dysmenorrhea is endometriosis, and it has a poor impact on life quality. Underestimation of dysmenorrhea and consideration of…
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Menstruating eye: Very rare but possible
By Eylül GÜN
Extragenital cyclical bleeding during a menstrual cycle is called vicarious menstruation and it is mostly reported to be seen in the nasal mucosa but can involve any other organ such as the lungs, stomach, kidney, etc. Endometriosis is a common…
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Vicious cycle: The promoting role of previous endometriosis foci for new lesions
By Nasuhi Engin Aydin
An experimental animal study on the pathogenesis of endometriosis from the Institute for Clinical and Experimental Surgery, Saarland University, Hamburg has been published in a recent issue of International Journal of Molecular Sciences. Endometriosis is a well-known common gynecological ailment…
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Omitted facet of endometriosis : mental health related to stigma
By Nasuhi Engin Aydin
A team of clinical psychologists involved in women’s health led by Deniz Kocas has published a recent review on the mental health aspect of endometriosis patients in the European Journal of Obstetrics & Gynecology and Reproductive Biology. Endometriosis is a notoriously…
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Endometriosis and Physical Activity
By Hale Goksever Celik
Endometriosis causes abstinence from their daily life, especially during painful periods. Decreased physical function might result in reduced physical activity. Sachs et al., from Switzerland, published a study titled “Physical Activity in Women with Endometriosis: Less or More Compared with…
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The Molecular Mechanisms of how herbal medicine Actaea racemosa modulates Endometriosis Progression
By Bahar Yuksel
Increased proliferation, dysregulated apoptosis, and a pro-inflammatory and oxidative environment are the hallmarks of endometriosis. In the article published in the Journal of Molecular Sciences, penned by Livia Interdonato et al, the molecular mechanisms of the extract from a plant…
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Treatment of superficial dyspareunia using topical estrogens in postmenopausal women with a history of endometriosis
By Hale Goksever Celik
Genitourinary syndrome of menopause is defined as a collection of symptoms and signs caused by hypoestrogenic changes to the labia majora/minora, clitoris, vestibule/introitus, vagina, urethra, and bladder that occur in menopausal patients. Sexual dysfunction and superficial dyspareunia can be experienced…
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Assessing endometrial receptivity using menstrual blood samples in patients undergoing in-vitro fertilization
By Eylül GÜN
Endometrial receptivity is the endometrium's capacity to allow the embryo the chance to adhere, infiltrate, and develop while ensuring an ideal microenvironment. When impaired, it is one of the two major factors contributing to infertility along with embryo quality by…
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Women With Endo Left Alone To Deal With Their Gut Symptoms
By Özge Özkaya
Women with endometriosis had patterns of restrictive behavior, according to a new study published in the European Journal of Obstetrics & Gynecology and Reproductive Biology. They also wanted more professional support to help them manage the gut symptoms associated with the…
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A review for genetics of endometriosis.
By Selma Oransay
There is an increased risk of developing endometriosis among first-degree relatives, which can raise suspicions of the role of genetic factors in endometriosis. Genome-wide association studies and next-generation sequencing have identified numerous genetic loci and variants relating to the disease.…
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Is continuous hormonal treatment safe and healthy method for endometriotic patients?
By Selma Oransay
One of the studies related to the search for new markers in pathophysiologic causes of endometriosis is circulating microparticles and their subset "tissue factor". In response to damage, activation, or apoptosis, these microparticles are found in human plasma, urine, saliva,…
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Toxic metal cadmium and Endometriosis
By Nasuhi Engin Aydin
Data analyst Mandy Hall and and colleagues from the Department of Epidemiology and Biostatistics, Michigan State University, USA, have published their results on cadmium levels and endometriosis in a recent issue of “Human Reproduction”. In 2020 the World Health Organization…
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Novel surgical solutions for catamenial pneumothorax
By Eylül GÜN
Catamenial pneumothorax is a spontaneous pneumothorax that occurs during or right after menstruation and is thought to be caused by thoracic endometriosis that includes the diaphragm, lung, and parietal pleura. The solution is surgical removal of endometrial lesions, however, a…
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Women With Endometriosis More Likely to Also Have Non-Specific Symptoms
By Özge Özkaya
Women with endometriosis are more likely to report menstrual symptoms, according to a new study published in the American Journal of Obstetrics and Gynecology. However, they are also at an increased risk of mental health disorders, other pain symptoms, bowel,…
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The compliance for post-surgical follow-ups after endometriosis surgery
By Selma Oransay
. The patient's adherence to follow-ups after surgery is essential as it is the only way to evaluate the surgery's benefits in improving pain symptoms and recurrences, measuring the quality of life, and fertility outcomes. . Dr. Szabo and his…
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Review of neutrophil based scientific research in endometriosis
By Nasuhi Engin Aydin
Xinlei Wang and associates from Jilin University, Changchun, China, have published a comprehensive review on the pathogenetic role of neutrophils in endometriosis in a recent issue of the periodical “Mediators of inflammation”. As a common inflammatory condition where endometrial tissue…
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A Starch-Based Gel Barrier Reduces Pain and Improves Fertility After Endometriosis Surgery
By Özge Özkaya
The development of pain was reduced in women with endometriosis who underwent surgery for deep infiltrating endometriosis (DIE) resection and the "gel barrier 4DryField® PH" was used during the operation, according to results from a randomized controlled trial. Moreover, fertility was improved. "4DryField® PH"…
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Harnessing the Power of the Immune System: The Potential of Immunotherapy for Treating Endometriosis
By Bahar Yuksel
The review article by Wenshu Li et al. discusses the potential of immunotherapy as a novel treatment for endometriosis and the potential to overcome possible side effects and recurrence rates related to conventional therapies. The article explains how immunotherapy, which…
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Pain Scoring System for Deep Endometriosis
By Selma Oransay
The numeric pain scale is commonly used to interpret pain score values. According to the National Comprehensive Cancer Network guidelines, pain scores of 4-7 points indicate moderate, and 8-10 points indicate severe pain. Patients with a local pain score of…
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Sexual activity during menstruation: Any impact on endometriosis development?
By Eylül GÜN
Retrograde menstruation is among the theories for the etiology of endometriosis and there is a hypothesis that sexual activity during menstruation could potentially increase retrograde menstruation, leading to the implantation of endometrial tissue in other areas and consequently increasing the…
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Menopause-management strategies for women with endometriosis.
By Selma Oransay
Menopausal hormonal therapy is the most effective treatment for menopausal symptoms, such as hot flushes, sweating, sleep disturbances, mood changes, and joint pain. Approximately 75% of all women experienced some degree of these symptoms, while 2-4% were diagnosed with endometriosis. Menopausal…
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Meningioma risk in women with endometriosis using Nomegestrol acetate
By Hale Goksever Celik
Women with endometriosis mostly suffer from symptoms such as chronic pelvic pain, dysmenorrhea, dyspareunia, and infertility. Early diagnosis and management have importance as endometriosis impairs the quality of life and creates a serious social and economic burden. There are different…
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Headaches Appear Years Before a Diagnosis of Endometriosis
By Özge Özkaya
Headache is associated with different forms of migraine, is related to pain, and often appears before diagnosis in women with endometriosis, according to a new study published in the scientific journal Reproductive Biomedicine Online. This knowledge can help ensure women with…
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Does ovarian endometrioma affect embryo aneuploidy rate in fertile women?
By Hale Goksever Celik
One of the most common clinical findings of women with endometriosis is the decline in fertility status. These women often benefit from in vitro fertilization methods to become pregnant. However, whether there is a detrimental effect of endometriosis on oocyte and…
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Improving the quality of life: The role of cognitive behavioral therapy after endometriosis surgery
By Eylül GÜN
Endometriosis and its symptoms have been associated with poor mental health and reduced quality of life. Cognitive behavioral therapy is recognized as an effective psychological treatment for managing depression, anxiety, and stress. Although surgery for endometriosis improves a patient's quality…
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Surgery for Deep Endometriosis
By Selma Oransay
In recent years, minimally invasive surgery has gained popularity, providing the best results in gynecologic cancers and deeply infiltrated endometriosis. With the help of a high-definition camera displayed on a TV monitor, the small structures are enlarged 4-7 times and…
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Integrative medical management of endometriosis
By Selma Oransay
This lecture entitled "Integrative Medical Management of Endometriosis" was presented by Dr. Pinar Kodaman, Director of the endoscopic reproductive surgery program and Assoc. Professor of Clinical ObGyn and Reproductive Sciences at the Yale School of Medicine. In addition to surgery which…
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2023 MedicalConferance: Pros and cons of hormonal interventions for endometriosis - Sarah Berga, MD
By Bahar Yuksel
Prof. Berga, MD., who is the Chair of Ob&Gyn at Jacobs School Medicine and Biomed Sciences, presented this speech at the 2023 EFA Medical Conference. Dr. Berga explains that the primary goals of endometriosis treatment are to reduce pain and improve quality…
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Anti-IL-8 antibody ameliorates inflammation and fibrosis: A promising treatment for endometriosis
By Eylül GÜN
Endometriosis is a condition associated with chronic inflammation and fibrosis, and there are limitations and side effects with current treatments such as hormonal therapy and surgery. Interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP1) are inflammatory cytokines that play a crucial…
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The bigger the uterus, the more painful the dysmenorrhea even if you don’t have endometriosis.
By Bahar Yuksel
The literature finds no correlation between ultrasound or perioperative findings and pain intensity. Thus, a tool to predict pain intensity will ease the choice for proper treatments and follow-ups. In the study led by Dr. Zhao et al., the ultrasonographic…
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Insights into the experiences of people with endometriosis during COVID-19 pandemic
By Selma Oransay
During the isolation of Covid 19 pandemic period, the most critical issue was healthcare access for patients. This was worse for patients who had chronic illnesses. Endometriosis is one of these chronic illnesses that need regular care, pain relievers, and…
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Laparoscopic resection of bladder endometriosis
By Selma Oransay
When we talk about deep-infiltrating endometriosis, one of the most commonly affected organs in the urinary tract is the bladder, with a prevalence of 80%. Bladder endometriosis can be defined as the existence of the endometrial glands and stroma inside…
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Comparison of two surgical approaches for endometriosis.
By Selma Oransay
Endometriosis is one of the causes of infertility in women. But the pathophysiology of infertility caused by endometriosis is not yet clear. Hormonal disorders, abnormal peritoneal function, distorted pelvic anatomy, and multiple cesarean deliveries are among the accused. Dr. Li…
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The effectiveness of acupuncture in the treatment of dysmenorrrhea
By Selma Oransay
Asymptomatic endometriosis does not adversely affect women's quality of life and mental health. But the quality of life of women with endometriosis who suffer endometriosis-related pelvic pain, dysmenorrhea, dyspareunia, and dysuria declines as they become more susceptible to anxiety and…
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Weighting (side)effects when dealing with endometriosis-associated pain.
By Bahar Yuksel
The treatment options for endometriosis-related pain are so many. And the guidelines leave the selection to the clinicians, which causes obscurity between preferences. In the study by Christine Poulos et al, the authors analyzed the response of clinicians on the…
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The most common gynecologic admissions to the emergency: Endometriosis and adenomyosis
By Hale Goksever Celik
Women with endometriosis demand therapy for the most common symptoms, which are pelvic pain and infertility. Adenomyosis occurs when the endometrial glandular and stromal tissue grows into the muscular wall of the uterus, called the myometrium. Women having adenomyosis also…
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Study Highlights Link Between Endometriosis and Mental Health Problems
By Özge Özkaya
Endometriosis is associated with mental health problems such as anxiety, depression, and eating disorders found a new study published in the journal JAMA Network Open. This is the first large-scale study showing a link between endometriosis and the mental health…
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Relation between hormone replacement therapy and postmenopausal endometriosis.
By Bahar Yuksel
The faith of endometriosis after oophorectomy with hysterectomy is unknown. It is clear that applying only a hysterectomy but leaving the affected tissue behind is not a solution for endometriosis-related symptoms. Either total clearance or leaving endometriotic tissues behind when…
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Endometriosis-Associated Pain: The Role of Sensitization
By Eylül GÜN
As the most common symptom of the disease, endometriosis-associated pain (EAP) is experienced as dysmenorrhea, non-cyclical pelvic pain, and cyclical pain related to organ function. EAP is contributed to by different mechanisms, including local factors, peripheral sensitization, central sensitization, cross-sensitization,…
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Younger Women With Endometriosis Feel More Pain
By Özge Özkaya
Younger women with endometriosis feel more period pain (dysmenorrhea) and pain during intercourse (dyspareunia) compared to older women with the disease, found a new study published in the Journal of Pediatric and Adolescent Gynecology. Acknowledging this fact can make sure…
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Diagnostic criteria for uterosacral ligament involvement in endometriosis.
By Selma Oransay
Transvaginal ultrasonography is often used to diagnose endometriosis in suspected women due to its high resolution, low cost, and relatively low discomfort. Histologic confirmation of laparoscopically removed specimens is still the gold standard for appropriate diagnosis. The team led by…
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Machine learning based potential biomarkers
By Bahar Yuksel
To explore potential biomarkers for an accurate diagnosis and treatment, and to elucidate the mechanism of endometriosis, Yi Huang et al, analyzed gene differences between eutopic and ectopic endometrium and the status of the immune microenvironment., and published their results in the…
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Gestrinone May Be Safe and Effective in Treating Endometriosis Symptoms
By Özge Özkaya
Gestrinone seems to be safe for the treatment of endometriosis, according to a new study published in the scientific journal Archives of Gynecology and Obstetrics. It also may be more effective than danazol and other medical treatments. However, these findings…
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Efficacy of Uterine Artery Blockage in Endometriosis Management
By Nasuhi Engin Aydin
Dr. Li Ma and associates from Liaoning, China have published their results of a computerized database search on the role of uterine artery embolization in endometriosis in a recent issue of the periodical “Computational Intelligence and Neuroscience”. Currently, the management…
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What causes pelvic pain? Androgens or estrogens?
By Selma Oransay
A comparison between women and men reveals that women suffer more pelvic pain. This reality raises the possibility of the pain-relieving effect of testosterone or androgens. It would be a wise solution to investigate how androgens affect pain at different…
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Anhedonia and its relation to endometriosis as a sole symptom
By Eylül GÜN
"Anhedonia may be defined as a broad category of hedonic function deficiencies, including diminished motivation or enjoyment capacity. It has been an area of interest for a long time in psychiatric disorders and has been crucial in some diagnoses such…
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Antimicrobial agent ornidazole yields promising effects in an animal model of endometriosis
By Nasuhi Engin Aydin
Xiaoduo Qin and collaborators from Chinese medical centers, have published their results on the role of ornidazole using an experimental rat model in a recent issue of the periodical “Gynecologic and Obstetric Investigation”. Progression of endometriotic foci depends on the presence…
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Non-hormonal medication for endometriosis-associated pelvic pain
By Selma Oransay
The thought of benefiting from non-hormonal therapy in endometriosis pain is based on the pathophysiological findings that include angiogenesis, fibrosis, the presence of inflammatory cytokines and immune cells, apoptosis, and stem cell theory. But the effect of this treatment in…
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Educational Programs Important to Raise Endometriosis Awareness
By Özge Özkaya
An educational program consisting of lectures and group discussions motivated nursing and medical students to seek medical attention so endometriosis can be detected and managed early, reported a new study published in the scientific journal Reproductive Biomedicine Online. However, this…
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Web-based resource to improve menstrual health awareness
By Selma Oransay
Many women consider "menstrual pain" a normal part of being female, and do not seek medical help but rather use self-management methods such as heat, rest, and analgesics. They are often unsure which self-management strategies are effective or what the…
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Social Support is a Predictor of Resilience in Women with Endometriosis
By Özge Özkaya
Satisfying social support and good mental health are key resources for resilience among patients with endometriosis, according to a new study published in the Journal of Clinical Medicine. “The results of this study may assist in the identification of women…
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Exposure to toxic metals and the risk of endometriosis
By Selma Oransay
Mercury, lead, and cadmium are the best-studied heavy metals for several adverse effects on the human reproductive system. Mercury can induce DNA damage, oxidative stress, and mitochondrial dysfunction, and lead exposure is associated with menstrual disorders, preterm birth, and miscarriage.…
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Endometriosis Increases Risk of Sexual Dysfunction But Only Before Menopause
By Özge Özkaya
Endometriosis increases the risk of sexual dysfunction, found a new study by US scientists. But this is the case only before menopause. This finding can guide doctors in decision-making about evaluating the sexual function of women with endometriosis who have…
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The association between severe endometriosis and venous thromboembolism
By Hale Goksever Celik
For clarifying the issue of whether endometriosis patients are at risk for venous thromboembolism due to both their local immune and inflammatory responses and hormonal treatments, Wiegers et al, from the Netherlands, published an explorative cohort study entitled “Risk of…
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Researchers Develop New Mouse Model of Endometriosis
By Özge Özkaya
Researchers from China developed a new mouse model to study endometriosis that could help researchers better understand the molecular mechanisms that lead to the development of endometriosis and develop potential new treatments for the disease. Even though many animal models…
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Pelvic pain characteristics in young girls with endometriosis.
By Selma Oransay
The occurrence of severe and frequent pelvic pain in young women is a piece of evidence that endometriosis begins and develops at an early age. Two-thirds of women with endometriosis who were diagnosed in their adulthood reported the onset of…
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Vitamin C as a possible therapeutic agent in endometriosis
By Eylül GÜN
A rather toxic environment is generated with the production of reactive oxygen species by the immune cells in endometriosis. The anti-oxidant metabolism is also altered which results in a state of oxidative stress. As a potent antioxidant, Vitamin C has…
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Study Identifies Factors Associated With Risk of UrinaryTract Endometriosis Recurrence
By Özge Özkaya
Being younger than age 25 and having an autoimmune disease are significant predictors of the recurrence of urinary tract endometriosis after surgery according to a new study published in the Journal of Minimally Invasive Gynecology. Adjuvant hormonal therapy, on the…
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To Remove the Ovary(ies) or Not During Hysterectomy for Endometriosis
By Selma Oransay
Some surgeons prefer empiric bilateral salpingo-oophorectomy during the hysterectomy of women with endometriosis based on the knowledge that endometriosis is stimulated by endogenous estrogens, as leaving the ovaries in situ may increase the possibility of endometriosis recurrence and pelvic pain.…
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Endometriosis and environmental factors
By Selma Oransay
The estrogen-dependent nature of endometriosis has generally led to search endocrine-based causes. Especially, polychlorinated biphenyls, dioxins, and Dietilstilbesterol are the most studied chemicals in the literature. Interesting data that needs confirmation in the future also suggest a link with night…
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Endometriosis and IBS Have Different Comorbidities
By Özge Özkaya
Comorbidities of endometriosis and irritable bowel syndrome (IBS) are different despite several overlapping symptoms, according to a new study published in the scientific journal Human Reproduction. These comorbidities are usually related to the organ systems that are primarily involved in…
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Validity of Magnetic Resonance Imaging for Deep Pelvic Endometriosis.
By Selma Oransay
Video laparoscopy has become a valuable tool for diagnosing and managing endometriosis in recent years. In cases associated with deep infiltrating endometriosis, the need for a non-invasive diagnostic method before laparoscopic evaluation paves the way for using MRI. The use…
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Does the timing of endometriosis diagnosis affect optimal infertility treatment?
By Selma Oransay
Based on a retrospective population-linked data study in "Human Reproduction", the ESHRE journal club featured a detailed discussion with 50 participants, patients’ representatives, and experts (Paola Vigano´, Mathew Leonardi, Thomas D’Hooghe, Louise Hull), together with the authors of the original article, mainly…
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New Endometriosis Self-Assessment Tool Could Help Women Seek Timely Medical Attention
By Özge Özkaya
Researchers from Korea developed a self-assessment tool that may allow women to determine their risk of endometriosis. They described the tool in an article they published in the scientific journal Obstetrics & Gynecology Science. “The devised tool appears valid and…
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Evaluation of retrocervical and parametrial deep endometriosis by detailed ultrasonography
By Selma Oransay
The accuracy of ultrasonographic diagnosis of deep endometriosis in the retrocervical and parametrial areas may be poor due to the variable morphology of endometriotic lesions, the complex structure of the posterior parametrial compartment, and the difference in examiners' experience level.…
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Endometrioma and its relation with fibrosis, dysmenorrhea, and AMH levels.
By Bahar Yuksel
Endometrioma is an indicator of endometriosis which makes it easy to diagnose the disease for most clinicians. But the symptoms and relationship of endometrioma with menstrual pain severity and the ovarian reserve as well as its markers are not well…
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Postoperative outcomes of deep intestinal endometriosis surgery.
By Selma Oransay
Invasion of endometriotic lesions to the bowels' mucosal and/or muscular levels is called intestinal deep endometriosis. These lesions are most frequently found in the rectosigmoid colon, followed by the rectum, ileum, appendix, and caecum. The optimal surgical approach to intestinal deep…
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Who Is Diagnosing my Endo?
By Özge Özkaya
It is possible to acquire the skills necessary to diagnose endometriosis lesions as well as adenomyosis using three-dimensional rectosonography after a short learning period in an expert radiology center. This is according to a new study by French researchers published…
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Early menarche increases the risk of endometriosis.
By Selma Oransay
Early menarche is the first menstrual bleeding occurring before 12 years of age. The timing of normal puberty in girls varies between nations due to genetic, socioeconomic, and environmental factors. Notably, the age of menarche decreased significantly in teenagers born…
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How does endometriosis affect the life course of the patients?
By Eylül GÜN
Endometriosis, as a chronic disease has impairing effects on women’s lives. Patients carry psychological, social, and work-related burdens along with debilitating physical symptoms. Studies have been performed on these issues at a particular time in patients’ lives, however, only a…
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Why Do Some Women Develop Endometriosis While Other Don’t?
By Özge Özkaya
Chemotaxis by natural killer cells as well as cytotoxicity is significantly decreased in the peritoneal cavity of women with endometriosis, according to a new study published in the American Journal of Reproductive Immunology. This means that antigens that enter the…
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The consequence of COVID-19 pandemic on endometriosis patients
By Selma Oransay
The relevant policies and restrictions concerning Covid-19 have prevented patients from accessing medical care. Similarly, standard care for endometriosis patients has also been negatively impacted by postponed or canceled appointments and suspended surgeries across the countries. Women trying to cope…
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Self-Management Strategies for Endometriosis
By Özge Özkaya
Many self-management strategies for endometriosis are not more effective at reducing the symptoms of the disease compared to placebo or hormonal therapies, according to a new study published in the journal Reproductive Sciences. The authors, therefore concluded that “no recommendations…
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Social media and endometriosis management
By Selma Oransay
Endometriosis has a negative impact on social life, work, daily activities, personal relationship, and overall quality of life. A study from Australia recently published in the Australian New Zeland Journal of Obstetrics and Gynaecology reports that social media helps these…
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Atherosclerosis is augmented in laboratory mice by experimental endometriosis
By Nasuhi Engin Aydin
Dr. Taylor group from Yale School of Medicine, New Haven, CT, USA has published their experimental study in the "American Journal of Obstetrics & Gynecology" on atherosclerosis following endometriosis induction in laboratory mice. The basic inflammation process in endometriosis patients…
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Geography May Influence Risk of Endometriosis
By Özge Özkaya
The risk of developing endometriosis seems to be geographically heterogeneous across France, according to results from a study published in the journal Scientific Reports. The study identified 20 high-risk hotspots around the country. These showed similar results for non-adenomyosis endometriosis…
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Which of the suggested environmental risk factors are indeed related to endometriosis?
By Eylül GÜN
Endometriosis is a complex disease with genetic and environmental factors in its poorly understood pathogenesis. Even though many epidemiological studies in the literature have proposed several risk factors, the lack of clear establishment and modification of these potential risk factors…
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Medicinal Cannabis Use for Endometriosis in Australia and New Zeland
By Özge Özkaya
Cannabis use leads to positive outcomes for the management of endometriosis according to the results of an online survey among patients from Australia and New Zealand. These findings, which were published in the journal Cannabis and Cannabinoid Research suggest that…
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Prevalence of endometriosis and adenomyosis by transvaginal ultrasound.
By Selma Oransay
Women who present dyspareunia, dysmenorrhea, dysuria, dyschezia, chronic abdominal, and pelvic pain, and infertility would benefit from the early investigation. If the correct diagnosis of endometriosis and/or adenomyosis can be made in advance, early treatment will improve the quality of…
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Mindfullness Can Hep Reduce Endometriosis Pain
By Özge Özkaya
A brief mindfulness-based intervention can be useful in managing pain related to endometriosis and restoring patients’ psychological well-being, found a new study published in the European Journal of Pain. This finding contributes to the applicability of mindfulness-based interventions in people…
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Quality of Life Is Negatively Correlated With Anxiety and Depression in Endometriosis
By Özge Özkaya
The quality of life of endometriosis patients is negatively correlated with anxiety and depression according to a new study published in the scientific journal Frontiers in Psychology. Based on this finding, the authors of the study suggest that improving patients'…
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Cannabis use in the management of endometriosis-related pain during the COVID19 pandemic
By Eylül GÜN
Pain management in endometriosis has been challenging owing to many reasons. Since the pathways that cause pain in endometriosis have not been elucidated extensively, the medical and surgical management of pain remains to be symptomatic. Alternative pain management methods have…
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Prolactin receptor antibodies: A novel treatment proposal for endometriosis
By Eylül GÜN
Prolactin, a hormone that also acts as a proinflammatory cytokine through its receptor PRLR has been shown to be involved in endometriosis pathogenesis. Previous studies reported that women suffering from endometriosis had elevated prolactin levels. Also, in experimental studies done…
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A novel scoring tool to standardize surgical complexity for gynecologists.
By Selma Oransay
The field of gynecologic surgery needs a more comprehensive, objective, and reproducible method for assessing and communicating surgical complexity than the current approach. Actually, there is no formal image-based system that allows surgeons to categorize and communicate the complexity of…
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Diaphragmatic defects, liver herniations and catamenial pneumothorax
By Nasuhi Engin Aydin
Dr. Arakawa and associates from The Jikei Katsushika Medical Center, Japan, have published their recent case of catamenial pneumothorax with diaphragmatic defect and liver herniation in the "Journal of Cardiothoracic Surgery". Catamenial pneumothorax is an uncommon condition with a reported…
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Evaluation of daily diary for endometriosis-related pain.
By Selma Oransay
Some endometriosis patient-reported outcomes elements have been previously developed in accordance with regulatory and best practice guidelines including Endometriosis Pain Daily Diary, the Endometriosis Symptom Diary, and Endometriosis Impact Scale. The aim of this study was to develop another content-valid…
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Endometriosis Seems to Affect The Development of the Embryo
By Özge Özkaya
Embryos development is impaired in embryos from women with endometriosis found a new study published in the Journal of Assisted Reproduction and Genetics. In spite of this, the outcomes of in vitro fertilization (IVF) are similar for patients with endometriosis…
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Envorinmental metals harmful for female reproductivity
By Selma Oransay
Heavy metals exposure in a wide range of ways is one of the main causes of increased infertility. According to the 2003 National Health Survey, nearly every pregnant woman in the USA is exposed to at least 43 hazardous chemicals…
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A New Simultaneous Tool to Assess Endometriosis Symptoms
By Özge Özkaya
Researchers from the Netherlands developed a new digital tool to assess the symptoms of endometriosis using the experience sampling method. This new method may help overcome the limitations of current questionnaires. “After validation and testing, future studies will be planned…
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The quality of life and mental health in endometriosis patients
By Eylül GÜN
One of the most important aspects of having a chronic illness comes with its relative effect on the patients’ quality of life and mental health status. Being among the most debilitating diseases in women in the reproductive period, endometriosis is…
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Emotions on the 'Surgery Requirement' in patients with bowel endometriosis
By Eylül GÜN
Endometriosis is known to have many adverse effects in patients’ lives such as a significant decrease in the quality of life, psychosocial problems, loss of productivity and focus while working. With the constant chronic pain, the patients mostly present with…
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An Overview on Treatment of endometriosis
By Selma Oransay
There are different guidelines by different gynecological societies for the diagnosis and treatment of endometriosis, which is an extremely complex illness. Kalaitzopoulos and Samartzis et al. from Switzerland worked on and compared six national and two international widely used guidelines to…
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A trial of exogenous melatonin on dysmenorrhea in women "without endometriosis"
By Nasuhi Engin Aydin
In their recent article published in “European Journal of Clinical Pharmacology”, Dr. Söderman and associates from Stockholm report the results of their randomized, double-blind, placebo-controlled trial on the effects of oral melatonin in women with dysmenorrhea -unrelated to endometriosis-. Melatonin is a hormone…
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Sexual Function in Women With Endometriosis
By Özge Özkaya
The sexual function of women diagnosed with endometriosis is impaired confirmed a new study by Spanish researchers published in the Journal of Clinical Medicine. According to the study, the strongest predictive factors for poor sexual function are deep disease, depression,…
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Cross-cultural translation and adaptation of an endometriosis survey
By Eylül GÜN
Endometriosis is a disease that presents heterogeneously which makes it hard to identify a causal relationship. A patient-based questionnaire called Endometriosis Participant Questionnaire (EPQ) has been originated by The World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project. It…
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The effect of hormone therapy after surgical menopause on endometriosis recurrence
By Selma Oransay
Definitive surgery for severe and advanced endometriosis is hysterectomy with bilateral oophorectomy, which may cause vasomotor symptoms, sleep deprivation, mood change, and dyspareunia in the patients. Furthermore, after the surgical removal of the ovaries, the sudden drop in estrogens causes…
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Pharmacological Therapy for Endometriosis Pain
By Eylül GÜN
The negative effects of endometriosis on women’s quality of life are indisputable. Women who suffer from endometriosis might have to deal with problems in many aspects such as psychological, sexual, social, and economic. Pain which is one of the most…
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Environmental factors play a role in the development of endometriosis
By Hale Goksever Celik
The proposed mechanisms underlying the development of endometriosis may be classified into three groups: in-situ theory, implantation theories, and induction theories. Genetic, hormonal, environmental, and lifestyle-related factors are also involved as no mechanism is solely responsible for endometriosis development. Although there are…
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The new Endometriosis Surgical Complexity Classification: AAGL 2021
By Selma Oransay
Multiple endometriosis categorizations have been approved in the recent forty years. The American Fertility Society proposed ASRM with a desire to score the impact of the endometriosis in 1996, which was updated several times later (rASRM), to predict infertility after laparoscopic operations. For…
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Dietary adjustments do not increase the quality of life of women with endometriosis.
By Özge Özkaya
Even though dietary changes do not seem to increase patients’ quality of life, they lead to a perceived reduction in symptoms. No specific adjustment in the diet increases the quality of life of women with endometriosis, according to a new…
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Could Cannabis Be Recommended to Manage Endometriosis?
By Özge Özkaya
It is not possible to recommend cannabis-based products to patients with endometriosis because there is not enough evidence supporting their benefits, according to a new study published in the Journal of Minimally Invasive Gynecology. Cannabis-based products have been suggested as…
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Phytoestrogens could have promising effects in endometriosis management
By Nasuhi Engin Aydin
Dr. Bartiromo and associates from Milan, Italy published a systematic review on phytoestrogens and endometriosis in the periodical “Nutrients”. Endometriosis has features of chronic inflammation based on uncontrolled hormonal response and immune-mediated dysfunctions. Estrogens are endocrine and paracrine agents that could yield…
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Lead and cadmium exposures of female workers should be reduced as much as possible
By Nasuhi Engin Aydin
Min-Gi Kim and associates from Korea published their results on the possible effects of lead and cadmium exposure in endometriosis induction and severity in a recent issue of “International Journal of Environmental Research and Public Health”. Endometriosis is an illness…
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Endogenous cannabinoids are related to endometriosis pain
By Eylül GÜN
Pain, specifically dysmenorrhea is the most important symptom of endometriosis. Prostaglandins are the main director of the pain process in dysmenorrhea, therefore the mechanisms affecting the prostaglandin metabolism have been studied in order to find a treatment for pain, and found that…
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Body Mass Index and indicators of metabolic syndrome in women with Endometriosis
By Hale Goksever Celik
Endometriosis is a disease of reproductive-aged women and has common pathophysiological mechanisms with other chronic health morbidities due to its estrogen-dependent chronic inflammatory background. The changes in the inflammatory components of adipose tissue may have an impact on the quality of…
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A new "nonhormonal" treatment target in endometriosis
By Eylül GÜN
Endometriosis is a chronic inflammatory condition that affects millions of women globally. With pelvic pain being its most common symptom, the cost of the treatment of disease-associated symptoms has been found to be almost as high as type 2 diabetes.…
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Impact of Endometriosis on Work Life in Finnish Women
By Özge Özkaya
Endometriosis is associated with poor "work ability" at late fertile age, according to a Finnish study published in the journal Acta Obstetricia et Gynecologica Scandinavica. Although women with endometriosis have more disability days, their employment rate and risk of early…
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Outpatient neuromuscular protocol may improve the quality of life in women with chronic pelvic pain
By Bahar Yuksel
Chronic pelvic pain syndrome is a complicated entity causing central and peripheric sensitization of nerves. The sensitization processes start a loop of unbreakable pain chain causing resistance to conventional therapy methods. The study conducted by Soha Patil et al covering data…
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A new assessment tool for the multi-dimensional burden of endometriosis
By Eylül GÜN
Endometriosis is a disease that has multiple effects on patients’ lives in various ways. The quality of life, the status of the patient’s relationships, the continuity and productivity in the patient’s education and work environment, and psychological, emotional, and even…
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Endometrioma post-surgical-recurrence risk factors
By Nasuhi Engin Aydin
Jiang and associates from Dailan Medical University, China published their review manuscript “Risk factors for ovarian endometrioma recurrence following surgical excision: a systematic review and meta‑analysis” in the June 2021 issue of "Archives of Gynecology and Obstetrics". The most common form of endometriosis, "ovarian…
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Depression and Anxiety Common in Women with Endo
By Özge Özkaya
Symptoms of depression and anxiety are frequent among women with endometriosis and are related to chronic pain, confirms a review of the literature and meta-analysis published in the Journal of Women's Health. According to the study authors, correlating factors should…
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Non-invasive Construction of Endometrial Organoids
By Eylül GÜN
Organoids are 3D culture structures established in vitro and they reflect the aspects of the tissue or the organ they represent. They are seen as important tools in the evaluation of normal development, disease course, and the prediction of the…
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The incidence and prevalence of endometriosis in a United States population-based study .
By Selma Oransay
To define the accurate incidence and prevalence estimates of endometriosis among nonselected cohorts in the USA, Christ et al. from the Departments of Obstetrics and Gynecology of the University of Washington, Seattle, planned a retrospective cohort study using the electronic KPWA…
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Endometriosis & adolescents: Overcoming the diagnostic delay via education
By Eylül GÜN
Although the diagnosis of endometriosis is still not timely even in adults, due to its common under- or misdiagnosis in adolescents, the diagnostic delay may further cause the adolescent women to wait to seek medical treatment. A group of researchers…
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Chemical Found in Self-Care Products May Be Linked to Endometriosis
By Özge Özkaya
There may be a link between exposure to phthalates and endometriosis according to a new study published in the Journal of Assisted Reproduction and Genetics. Although more research is needed, these findings could be translated into clinical practice according to…
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Transvaginal Ultrasound Accuracy for Uterosacral Ligament, Torus Uterinus and Posterior Fornix Endometriosis
By Selma Oransay
The accuracy of transvaginal ultrasonography for the diagnosis of deep endometriosis depends on the location. The sensitivity is up to 80% when the lesion is in the rectosigmoid, but it decreases up to 66% for the detection of posterior vaginal…
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Non-pharmacological self-care: dietary modifications in women with endometriosis.
By Selma Oransay
The academic interest on the role of diet in endometriosis has grown due to its possible relation with inflammation, estrogenic activity, and menstrual cycles. Multiple dietary strategies and prescriptions are being used to deal with the pelvic pain and gastrointestinal…
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Strong Geographical Gradient in Endometriosis Incidence Identified
By Özge Özkaya
The geographical distribution of new endometriosis cases showed a very strong north-south spatial gradient in the highly industrialized Friuli Venezia Giulia region of Italy, according to a new study published in the International Journal of Environmental Research and Public Health. “The cluster of…
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Exploring a bonafide biomarker to predict endometriosis
By Eylül GÜN
Endometriosis is a complex disease affecting many women in the reproductive age group. As it is important to figure out the mechanisms responsible for the disease, it is also crucial to identify biomarkers that can be used in the diagnosis…
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Promising therapeutic results in experimental endometriosis model
By Nasuhi Engin Aydin
Tiziana Genovese and associates from Italian academic centers reported their pioneering findings in an experimental model of endometriosis administering an anti-tumor agent and glucocorticoid combination, published in the scientific periodical “International Journal of Molecular Sciences”. Endometriosis is a worldwide common disease…
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Impact of adenomyosis on sexual life
By Selma Oransay
Considering the similar etiopathogenesis and pain symptoms between adenomyosis and deep infiltrating endometriosis, Alcalde et al. from the Department of Gynecology, University of Barcelona, Spain, aimed to call attention to the presence of potential sexual dysfunction not only in patients with deep…
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Managing Persistent Pelvic Pain in a distinct "pain" clinic
By Selma Oransay
Persistent pelvic pain is an important problem producing physiological stress and productivity loss during the reproductive period of women. A specific pelvic pain clinic named "Mater Health Persistent Pelvic Pain Clinic" was established in 2017 in a part of the emergency…
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Retinol-binding protein in endometriosis pathogenesis
By Nasuhi Engin Aydin
Dr. Jae Chul Lee and associates from the Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, have published the recent results of their research on endometriosis regarding the role of retinol-binding protein4…
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Factors affecting complications and the recurrence of operated deep infiltrating endometriosis
By Selma Oransay
Deep infiltrating endometriosis is classified as penetrating the endometrial tissues more than 5 mm deep on the peritoneal surface, mainly uterosacral ligament, rectovaginal septum, ovarian fossa, pelvic peritoneum, bowels, ureters, and bladder. Treatment of the disease depends on the need…
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The higher the cyst fluid iron concentration, the more severe the pain symptom for endometrioma
By Hale Goksever Celik
Endometriosis usually is encountered in three different forms: superficial peritoneal endometriosis, ovarian cysts (endometrioma) and deep infiltrating endometriosis. Endometrioma can be identified as cystic lesions consisting of dark brown endometrial fluid and are sometimes referred to as "chocolate cysts." The presence…
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Endometriosis in intestine! Segmental resection or linear nodulectomy?
By Bahar Yuksel
Intestinal involvement of endometriosis is common, and the incidence was defined between 45-56%. Previous studies investigating the role of surgery in the management of intestinal endometriosis reported improvement of life quality in up to 95% of cases following surgery. However,…
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Postoperative treatment and pregnancy points to decreased recurrence risk for ovarian endometriosis
By Hale Goksever Celik
Endometriosis is a disease most frequently diagnosed in women of reproductive age and negatively affects the quality of life. The most common localization for endometriosis is ovaries with a prevalence of 17-44%. Laparoscopic ovarian cystectomy performed as excision or ablation…
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Pain Sensitization and What Should Be Done About it?
By Özge Özkaya
Pain sensitization and lumbopelvic impairments are common among women with endometriosis, especially if they have advanced stage disease. This is according to a study by researchers in Spain that was published in the scientific journal "Pain Medicine". The finding underscores the…
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Managing the physical and emotional effects of endometriosis
By Hale Goksever Celik
Endometriosis is known to affect 5-10% of the general population, but some women are underdiagnosed due to physical and psychological disability. Due to the symptoms including dysmenorrhea, dyspareunia, chronic pelvic pain and infertility, endometriosis has a negative effect on the quality…
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The incidence of endometriosis and pelvic pain in transgender man
By Bahar Yuksel
Transgender operations are quite common all around the world and hysterectomies are performed almost 1 in 5 of this population. The studies conducted until now mostly evaluated operative and postoperative outcomes, but the present research also questioned the preoperative symptoms and…
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Do Adolescents Know About Endometriosis?
By Özge Özkaya
Most secondary school girls have painful periods and many of them don’t know what typical periods are like, according to a study published in the "Journal of Pediatric and Adolescent Gynecology". The majority of the girls do not have knowledge…
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Self-management and the quality of life in women with endometriosis
By Hale Goksever Celik
Endometriosis symptoms can range from mild to severe. The most common presenting complaints are mainly pelvic pain and infertility. There is no doubt that the physical and mental quality of life of these women is adversely affected. There are several studies…
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Egg Freezing for Endometriosis: Should she rush - Tomer Singer, MD
By Özge Özkaya
In this presentation, Dr. Tomer Singer, a fertility specialist and the medical director at Shady Grove Fertility in Manhattan, New York talks about egg freezing and its importance for women with endometriosis. He emphasizes the importance of having an endometriosis…
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By Irem OnurExploring Pelvic Pain: Deep to Ischial Spine Including Pre-Sacral Roots - A. Taner Usta, MD
By Irem Onur
Chronic pelvic pain is defined as pain in the pelvic area that lasts for 6 months or longer and results in functional or psychological disability or requires intervention and treatment by the American College of Obstetrics and Gynecologists. There are…
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By Ellen TumimbangWhy Persistent or Recurrent Endometriosis Happens? - Dan Martin, MD
By Ellen Tumimbang
The objectives of Dr. Martin in this presentation are to understand the difficulties in recognition of deep and hidden endometriosis, difficulties in recognition of small lesions of micron size, and differentiate the look-alike lesions of endometriosis. He addressed overcoming these…
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Endometriosis: Less is better. How to improve the integration between surgical and medical therapy - Errico Zupi, MD
By Özge Özkaya
In this presentation, Dr. Errico Zupi, Associate Professor in the Department of Obstetrics and Gynecology at the University of Rome talks about the importance of an integrative approach comprising of both medical and surgical interventions to treat endometriosis. "The first…
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How to unveil the discrepancy regarding the effect of chemicals on the etiology of endometriosis
By Nasuhi Engin Aydin
Kristen Upson from Michigan State University published a review article evaluating research papers on environmental factors effective in endometriosis from an epidemiological perspective in "Current Epidemiology Reports". Endometriosis is a multifactorial disease with anatomical, hormonal, immunological, estrogenic, genetic, epigenetic, and…
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Segmental bowel resection could be predicted using MRI in patients with rectal endometriosis
By Hale Goksever Celik
The rectum and recto-sigmoid junction are the preferential localisations of bowel endometriosis. The three main surgical approaches are shaving, disc excision, and segmental resection. It is very important to decide the most appropriate surgical method preoperatively and to plan accordingly. …
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CA125 do not correlate with pain and its severity among adolescents
By Ellen Tumimbang
Cancer antigen 125 (CA125) is a high molecular weight glycoprotein expressed in tissue derived from the coelomic and Mullerian epithelia including the uterus endometrium. Previous studies reported that CA125 is the most studied endometriosis marker. Women with endometriosis experienced different…
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By Yu YuBad bad lipid go away!
By Yu Yu
Much like the progression of endometriosis, accumulating evidence suggests that systemic chronic inflammation and oxidative stress can contribute to atherosclerosis. The excess low-density lipoprotein increases inflammatory processes in the arteries, which may result in atherosclerosis. Previous studies have shown that…
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By Timur SeckinBody mass index, the incidence of endometriosis and the severity of dysmenorrhoea
By Timur Seckin
According to a case-control study conducted by researchers from China, there is no association between body mass index (BMI) and the incidence of endometriosis. This finding contrasts with the conventional knowledge that low BMI is a risk factor for endometriosis.…
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The peculiarity of adolescent endometriosis
By Selma Oransay
Recent studies showed the prevalence of endometriosis in adolescents with chronic cyclic or acyclic pelvic pain is about 60-70%. Moreover, all stages of endometriosis, including deeply infiltrating endometriosis can be found in this population. Gubbels et al. from the Department…
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Sexual Quality of Life in Women With Endometriosis
By Özge Özkaya
Painful intercourse, more severe period pain, worse health-related quality of life, and unemployment are all associated with worse sexual quality of life in women with endometriosis. This is according to a Dutch study published in the scientific journal Sexual Medicine.…
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Pain and Quality of Life Following Surgical Treatment for Endometriosis
By Ellen Tumimbang
Currently, laparoscopy is the preferred approach as a surgical treatment of endometriosis. Many studies have shown the effectiveness of laparoscopic surgery to reduce the painful symptoms and improve the quality of life for patients with endometriosis in the short term…
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Endometriosis-related obstetrical complications and their outcome
By Selma Oransay
Borisova et al. from the Department of Gynecology and Obstetrics of Peoples' Friendship University, Moskow, Russia, and her colleagues from the Center of Perinatal and Reproductive Medicine of University Perugia, Italy, recently published a review of the literature data about…
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Time for reassessment : Laparoscopic surgery and bowel endometriosis
By Nasuhi Engin Aydin
Ferrero and associates from medical centers of Verona and Genoa, Italy, made a comprehensive review covering all aspects of the surgical approach to bowel endometriosis, published their results in "Best Practice & Research Clinical Obstetrics and Gynaecology". Bowel endometriosis is the…
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Predictors of voiding dysfunction after surgery for deep endometriosis
By Selma Oransay
While surgery for deep endometriosis provides relief and improves the quality of life in symptomatic patients for whom medical therapy has limited effect, it may also create postoperative lower urinary tract dysfunction. Moreover, postoperative voiding dysfunction could affect the quality…
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Deep Endometriosis or Recto-uterine Obliteration Without Endometrioma
By Selma Oransay
The diagnostic help of ultrasound is increasing by its ability to diagnose deep infiltrating and rectouterine pouch obliteration in patients who are suffering from chronic pelvic pain. Clinicians are used to evaluating the rectal and parametrial areas of the endometriotic…
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New Rat Model of Endometriosis Could Help Researchers Develop New Treatments for the Condition
By Özge Özkaya
Researchers in Belgium developed a new rat model of endometriosis. The animals showed signs of ongoing pain meaning that the model could provide a tool for researchers to develop potential new ways to treat the different symptoms of the condition…
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Diagnosis and treatment of endometriosis in adolescents
By Irem Onur
The belief that dysmenorrhea, the primary symptom of endometriosis, in adolescents is an inevitable condition seen in menstruation as well as unwillingness to perform diagnostic laparoscopy may cause the delay of diagnosis of endometriosis. This is according to a recent…
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Endometriotic mesenchymal stem cells may promote endometriosis
By Yu Yu
The cause of endometriosis is still debatable. Many researchers have accepted that retrograde menstruation, where the endometrial fragments released during menstruation attach and colonize the ectopic locations, is the most plausible reason. However, the numbers just do not add up.…
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The Impact of Painful Sex on the Physical and Mental Wellbeing of Adolescent and Young Adult Women
By Özge Özkaya
Clinicians should ask adolescents and young women about painful sex, not just talk about contraception and the prevention of sexually transmitted diseases. This is because painful sexual intercourse could have a negative impact on relationships and peer engagement, which is…
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Voiding Dysfunction after Colorectal Surgery for Endometriosis
By Timur Seckin
Postoperative voiding dysfunction is a less frequent complication of rectal shaving than that of discoid excision or segmental resection in patients undergoing colorectal surgery for endometriosis, regardless of its definition. This is according to a meta-analysis conducted by researchers from…
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Hormone Therapy Before Endometriosis Surgery
By Yu Yu
Hormonal therapy can be effective for endometriosis, although laparoscopic surgery is required for the frequent drug-resistant symptoms. Laparoscopic surgery can markedly improve endometriosis-associated pain. The administration of GnRH agonist prior to endometriosis laparoscopic surgery may be beneficial to improve surgical…
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Fallopian tubes and endometriosis
By Selma Oransay
There are multiple theories to explain the pathogenesis of endometriosis, among which the most popular one is Sampson's retrograde menstruation theory. The role of endometrial stem cells/progenitors are widely studied to support the origin of ectopic lesions in recent decades.…
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Suggested remedies for endometriosis patients during coronavirus pandemic
By Nasuhi Engin Aydin
The pandemic of COVID-19 continues to have important effects on endometriosis patients worldwide. Many health care facilities stopped providing surgical management and outpatient appointments are canceled or postponed. Dr. Leonardi from Australia and associates from several countries published their proposals…
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Cabergoline or Progesterone not Effective in Rat Model of Endometriosis
By Özge Özkaya
Oral treatment with cabergoline or micronized progesterone for four weeks is not effective in the regression of endometriotic implants in a rat model of the disease. This is according to a study published in the "Journal of Investigative Surgery". Cabergoline…
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Adolescent dysmenorrhea diagnosis and management
By Hale Goksever Celik
Endometriosis is usually diagnosed in reproductive-aged women. However, recent literature proved that clinical symptoms of endometriosis are also seen the adolescent girls and young women. Dysmenorrhea, the most common gynecologic complaint among this age group, can develop due to endometriosis.…
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By Nadire DuruBone morphogenetic protein and endometriosis
By Nadire Duru
Endometriosis is a chronic disease characterized by the presence of endometrial glands and stroma outside the uterus, associated with several discomforts such as pelvic pain, menstrual disorders, and infertility. Although endometriosis is categorized as a benign lesion, the ectopic endometrial…
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Anogenital distance and endometriosis
By Timur Seckin
Endometriosis may be associated with exposure of the embryo to chemicals called ‘endocrine disruptors’. Exposure to endocrine disruptors can be estimated by measuring the anogenital distance (i.e. the distance between the clitoris and the anus), using a centimeter ruler with…
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Estrogen Receptors and Endometriosis: What do we know now?
By Yu Yu
It has been well known that endometriosis is closely associated with steroid hormone metabolism and pathways. Estradiol promotes the growth and progression of endometriotic tissue, together with the associated inflammation and pain-related symptoms. Excess estradiol in endometriosis is mainly produced…
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International experts commentary for assisted fertility treatment facilities amidst COVID-19
By Nasuhi Engin Aydin
A multinational and multi-institutional commentary led by Dr. Alviggi from Italy and Dr.Esteves from Brazil has addressed important issues on assisted reproductive technology treatment amid COVID-19 lockdown suggesting remedies in the journal of "Reproductive Biology and Endocrinology" May 2020 issue.…
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Racial and ethnic disparities and women health
By Selma Oransay
The well documented racial and ethnic disparities in Obstetrics and Gynecology in the US make available to use them as an indicator of implicit bias in giving unequal health and care service to minorities. Dr. Bryant from Massachusetts General Hospital,…
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The effect of endometriosis on the quality of life
By Hale Goksever Celik
Endometriosis, the disease defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity, can be diagnosed in the reproductive-aged women with an incidence of 7-15%. However, endometriosis is observed in women with chronic pelvic pain syndrome…
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A hope for postoperative symptomatic endometriosis therapy
By Irem Onur
A new chapter in the treatment of symptomatic endometriosis patients may begin since new medical approaches including oral GnRH antagonists, selective progesterone receptor modulators, aromatase inhibitors, and peritoneal immune response modulators are being actively evaluated. To date, there was only…
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By Deniz KocasRacial Bias in Pain Assessment and Treatment Recommendations
By Deniz Kocas
This study, published by Hoffmann et al. in the April 2016 issue of Proceedings of the National Academy of Sciences, found that false beliefs about biological differences between blacks and whites are associated with the perception that black people feel less pain than do white…
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Opioids use in women with endometriosis, what does it tell us?
By Yu Yu
Endometriosis is a debilitating disease that can cause many painful symptoms such as dysmenorrhea, dyspareunia, infertility, chronic pelvic pain, abdominal pain, and sacral or low back pain. More than half of women diagnosed with endometriosis suffer from chronic pelvic pain.…
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Endometriosis by Race
By Hale Goksever Celik
Endometriosis is usually diagnosed in reproductive-aged women with an incidence of approximately 10%. The most common presenting symptoms are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility in patients with endometriosis. Some risk factors have been identified for the development of…
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Discrepancies between racial/ethnic groups and choice of hysterectomy procedures
By Nasuhi Engin Aydin
Dr. Pollack and associates from Washington University, St.Louis, made multistate research regarding the patient profile in hysterectomies and published their results in the 2019 December issue of "The Journal of Minimally Invasive Gynecology". The most frequently performed nonobstetric surgery in…
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How Can Racial and Ethnic Disparities Be Reduced Among Women’s Health and Healthcare?
By Özge Özkaya
The American College of Obstetricians and Gynecologists published a set of recommendations to help reduce racial and ethnic disparities in women’s health and healthcare and encourage obstetricians, gynecologists, and other health care practitioners to engage in activities to help achieve…
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Case-control study to develop a questionnaire for early diagnosis of endometriosis
By Nadire Duru
Endometriosis, which affects 5–10% of women of reproductive age, is a chronic gynecological disease characterized by the presence of endometrial glands and stroma outside the uterus, associated with several discomforts such as pelvic pain, menstrual disorders, and infertility. Ultrasound evaluation…
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Postmenopausal endometriosis: Is it a rare phenomenon?
By Hale Goksever Celik
Endometriosis, the estrogen-dependent disease defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity, is generally diagnosed in the reproductive-aged women. However, recent literature proved that this disease can also be observed in the premenopausal and…
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Endometriosis and Insomnia
By Timur Seckin
There should be more awareness among clinicians for the relationship between insomnia and endometriosis, the study suggests. There needs to be a suspect of endometriosis whenever the clinician faces women of reproductive age with sleep or insomnia-related symptoms. This symptom is…
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Appendiceal endometriosis
By Selma Oransay
Jeong et al. from the Departement of Surgery, Trinity School of Medicine, Saint Vincent, recently published their interesting appendectomy case in "Hong Kong Medical Journal". In their case, endometriosis inside the cavity of the appendix mimicked appendicitis, the patient submitted…
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Defective “ferroptosis”: a new pathogenetic explanation of endometriosis
By Nasuhi Engin Aydin
Dr. Ng and associates from Tufts University School of Medicine, Boston, USA made a comprehensive review of the role of the iron element in the development of endometriotic lesions. Though iron element is essential for cell survival, and its deficiency is important…
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Transvaginal sonography for predicting the distance between rectosigmoid endometriosis and the anal verge
By Timur Seckin
For optimal surgery, pre-surgical assessment of the distance between rectosigmoid deep endometriosis lesions and the anal verge (Lesion to Anal Verge Distance-LAVD) is recommended by many specialists. A group of researchers from Norway, Austria, and Australia studied the accuracy of…
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Oxidative stress leads to elevated cytokines, excessive structural damage and angiogenesis
By Yu Yu
Endometriosis is characterized by elevated intracellular reactive oxygen species, which is then believed to upregulate inflammatory cytokines. Reactive oxygen species also regulate the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), which is closely linked with immune responses.…
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Surgical approach to rectovaginal endometriosis.
By Selma Oransay
Recto-vaginal endometriosis incidence is estimated at 3.8%-37% among women with endometriosis and when it exists it's a part of deeply infiltrated endometriosis, thus advance stage endometriosis. Raimondo et al. from the Department of Obstetrics and Gynecology of the University of…
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By Dr. Youngran ParktRNA-derived fragments in ovarian endometriosis?
By Dr. Youngran Park
Endometriosis is an estrogen-dependent mysterious disorder characterized by the presence of endometrium outside the normal location of the uterus cavity. This disease affects approximately 10% of reproductive-aged women and becomes a major reason for infertility in reproductive-aged women and dysmenorrhea…
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Long-term Pregnancy Results after Surgical Removal of Endometrioma
By Irem Onur
Sun et al., from China, investigated the pregnancy outcomes and the related factors in patients with endometrioma and stage III-IV endometriosis along with a long-term follow-up postoperatively. Their study has recently been published in the journal named "Advances in Therapy".…
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All aspects of endometriosis reviewed with focus on modern management
By Nasuhi Engin Aydin
Dr. Chapron and associates from academic centers in France published in Nature Review Endocrinology, a comprehensive review on endometriosis. The article is inclusive of all aspects of endometriosis but especially focuses on the management of the disease with its contemporary status. Having a…
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Cycle-related gastrointestinal complaints in reproductive age young women
By Timur Seckin
An analysis of 1-year data on 266 patients who presented to the Clinic and Polyclinic for Gynecology and Reproductive Medicine at Jena University Hospital to undergo surgery for endometriosis and its symptoms was performed by Nicolaous K. et al., a…
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Phytotherapy as an alternative endometriosis treatment
By Dr. Youngran Park
Endometriosis is an estrogen-dependent gynecological disease that affects 5–10% of women in fertile age. Different therapeutic strategies are available to treat this disease, such as surgery, hormonal therapies, and nonsteroidal anti-inflammatory drugs. Medical therapy usually consists of different hormonal drugs,…
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Understanding endocannabinoid system in endometriosis
By Yu Yu
Endocannabinoids and their receptors are expressed throughout the body but have only been recently studied in depth since endocannabinoids were being discovered in 1992. In the female reproductive system, the cannabinoid receptor is expressed in the endometrium, the myometrium, the…
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An important environmental contaminant dioxin has links to the pathogenesis of endometriosis
By Nasuhi Engin Aydin
Giampaolinoa and associates from the University of Genoa, Italy published a review on environmental contaminant dioxin and its possible epigenetic role related to endometriosis development in "Gynecological Endocrinology". The authors made a narrative review, with the results of their search…
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Strength exercise may not be helpful for the management of endometriosis-related pain
By Yu Yu
Women with endometriosis often suffer from pelvic pain, although the disease severity is not correlated with pain intensity. Research in pain symptoms suggests that several neuromodulatory events are involved, including reduced peripheral induced pain thresholds and significant changes to the…
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A review of endometriosis in adolescent girls and young women
By Hale Goksever Celik
Endometriosis is an estrogen-dependent disease which is commonly diagnosed in reproductive-aged women. On the other hand, this disease can develop earlier in life due to different etiopathogenetic mechanisms. Especially adolescents who experienced neonatal uterine bleeding are under the risk for…
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β-catenin signaling, a new therapeutic target in endometriosis
By Yu Yu
Endometriosis is characterized by cell proliferation, resistance to cell death and fibrotic scarring. It is treated by surgical removal of the peritoneal lesions and ovarian cysts or using hormonal agents. However, the success of the current treatment is limited by…
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How to design patient-centered interventions to meet the needs of endometriosis patients
By Selma Oransay
The treatment of endometriosis is not perfect and necessitates the development of patient-oriented care initiatives. On this basis, patient-related transparent information should be the priority for researchers to find out a way for targeted interventions. Steele et al. from Australia and…
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Recent advances in the diagnosis and treatment of endometriosis
By Hale Goksever Celik
Endometriosis is an estrogen-dependent disease that is commonly diagnosed in reproductive-aged women. The most common complaints of women with endometriosis are pain and fertility problems. Although many advanced types of research about the etiology, differential diagnosis and treatment have been…
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Surgery and the endometriosis associated-pain: A systematic review
By Selma Oransay
The surgical approach for pelvic pain-related to endometriosis depends on the stage and the type of the endometriotic lesion and ranging from ablation and the excision of the lesions to radical surgery as hysterectomy with removal of ovaries and presacral…
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By Demet Candaş GreenIs deep infiltrating rectosigmoid endometriosis a progressive disease?
By Demet Candaş Green
This study by Netter at al., published in "Human Reproduction" in November 2019 aimed to assess the risk of progression of deep endometriotic nodules infiltrating the rectosigmoid and to evaluate the influence of continuous amenorrhoea (absence of menstruation) on the development…
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Risk of placenta previa is elevated in endometriotic women who underwent surgery.
By Selma Oransay
In the last decade concerns raised for surgical operations performed before pregnancies of endometriotic patients due to significantly increased risk of pregnancy complications such as placenta previa, preterm birth, hypertensive disorders of pregnancy, placental abruption, postpartum hemorrhage and small baby…
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Cannabis usage among Australian women with endometriosis
By Irem Onur
Sinclair J. et al., a group of researchers from Australia, conducted a cross-sectional online survey to determine the prevalence, tolerability, and self-reported effectiveness of cannabis in women with endometriosis. This study included 484 women with complete responses. Of all women,…
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Recurrent endometriosis is a real challenge both for the patients and clinicians
By Hale Goksever Celik
Endometriosis is defined as the localization of endometrial stromal and glandular cells outside the uterine cavity. Current medical and surgical treatment options have several limitations including the side effects, costs, risk of recurrence, effects on conception capability. Recurrence is a…
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A rigorous literature review on endometriosis
By Irem Onur
Bulun SE. et al., from Feinberg School of Medicine, Northwestern University, Chicago, conducted a rigorous literature review on endometriosis. This outstanding review by Dr. Bulun et al. addresses the definition, remarkable medical features, clinically useful research findings, prevalence and distribution,…
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Optimal Management of Endometriosis and the associated pain
By Yu Yu
Around 5–10 million reproductive-aged women suffer from endometriosis in the United States. The condition is hard to diagnose due to large variation in symptoms, though most women experience pain that can either be cyclical pelvic pain with menses or noncyclic…
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Study Sheds Light on Physiological Processes Associated with Endometriosis
By Özge Özkaya
Sensory nerves play an important role in the development of endometriosis as well as fibrosis, confirms a study by Chinese researchers. A better understanding of physiological processes associated with the development of endometriosis can help researchers devise new ways to…
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Consquences of endometriosis in menopausal period.
By Selma Oransay
Marie-Scemama et al. from Foch Hospital, Suresnes, France, referred to endometriosis and menopause which is an actual cruising topic and recently published it in the journal named "Hormone Molecular Biology and Clinical Investigation". Endometriosis a well-known estrogen-dependent disease has three…
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How does pregnancy affect endometriosis?
By Hale Goksever Celik
Endometriosis is the localization of endometrial stromal and glandular cells outside the uterine cavity. Pregnancy is offered as a treatment option for patients with endometriosis because it causes atrophy of endometrial cells similar to progesterone treatment. Progesterone predominance during pregnancy,…
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Endometriosis and the quality of life
By Selma Oransay
Recent developments of technics and improvement of skill in the laparoscopic field increased the courage of clinicians to attempt early and multiple diagnostic operations on endometriotic patients. Vanuccini et al. from NEUROFARBA, University of Florence, Florence, Italy recently published their…
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Is there an association between endometriosis and sexual activity during menstruation ?
By Nasuhi Engin Aydin
This recent case-control study with 185 women having endometriosis and 370 women as a control group was conducted in Tebriz University, Iran by Dr. Mollazadeh and associates. Contemporarily, retrograde menstruation is a valid theory for disseminating endometrial tissue to the…
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Analysis of childless women with endometriosis
By Irem Onur
Facchin F. et al., from Italy studied if the beliefs of childless women regarding motherhood, female identity, and infertility affected their psychological health. They have recently published their study in the Journal of Health Psychology. The data of this study were…
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How Long Does it Take to Be Diagnosed with Endometriosis?
By Özge Özkaya
It takes a median of eight years to reach a diagnosis of endometriosis from when the symptoms of the condition first appear confirmed a new British study. Interestingly, it seems that the earlier the symptoms appear, the later the disease…
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Patients preferences for the treatment of endometriosis-associated pain
By Hale Goksever Celik
Endometriosis is defined as the location of endometrial stroma and glands outside the uterine cavity. The most common presenting complaints are mainly dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility, most of which relate to the menstrual period. Those women affected…
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MicroRNA Inhibitor as an Endometriosis treatment
By Dr. Youngran Park
Endometriosis is a well-known estrogen-dependent gynecological disorder. This disease affects approximately 20% to 50% of infertile women and 10% of reproductive-aged women resulting in infertility and pelvic pains. In order to find endometriosis-specific treatment, various studies have been tried to…
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Adolescent dysmenorrhea and future endometriosis
By Selma Oransay
Dysmenorrhoea is typically classified as primary, or secondary due to underlying pathologies like fibroids, endometriosis, adenomyosis or uterine anomalies. Generally, long-term dysmenorrhea is present in endometriotic patient's anamnesis, but until recently, the research to clarify this connection remained retrospective. Knox et…
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Impact of Endometriosis on Embryo Development
By Dr. Youngran Park
Endometriosis is a hormone-dependent disorder which affects approximately 10% of women in reproductive age. There are many endometriosis-related problems, but infertility is one of the well-known issues which should be handled and understood. Despite numerous trials, the mechanisms and pathology…
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Clinical trial for the use of oral lactobacillus on endometriosis pain severity
By Yu Yu
The standard treatment of endometriosis consists of surgery and hormonal based treatment. There is evidence for the efficacy of these types of treatment, although their side effects remain a critical consideration for women. Based on molecular studies, changes in the…
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What happens to women with endometriosis after menopause?
By Selma Oransay
Endometriosis affects women in their reproductive period of life, with expected regression of lesions in the postmenopausal period. Literature about postmenopausal endometriosis assessing the prevalence, pathogenesis, and treatment is limited. As 2-5 % of postmenopausal women are affected by this uncommon condition, developing stress…
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Disparities in Access to Healthcare in Women with Endometriosis
By Özge Özkaya
There are significant differences in the use of medical services and prescriptions between women with endometriosis who have private healthcare and those who don’t. This is according to a study published in the American Journal of Obstetrics and Gynaecology. This…
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Fusion US/MR imaging in the evaluation of deep infiltrating endometriosis
By Timur Seckin
Scioscia M. et al., from Italy presented a case of a large deep infiltrating nodule of the uterosacral ligament and discussed the importance of a relatively new technique, fusion US/MR imaging in their article. The article containing a video of…
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A position statement of diagnosing and treating endometriosis for gynecologists.
By Selma Oransay
Endometriosis Treatment Italian Group recently declared 10 "valuable" conducts to evaluate endometriotic patients and published them in Hum. Reprod. Open. This society consists of 16 university departments and training center with expert clinicians on endometriosis from Italy. After arising the idea of…
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Babies Born Lighter May Have a Higher Risk of Developing Endometriosis Later in Life
By Özge Özkaya
Being exposed to growth restriction before birth seems to be associated with a higher risk of developing endometriosis during a woman’s reproductive years. Other factors such as having fewer liveborn children and prior infertility problems, also seem to be important…
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Chronic Fatigue Syndrome and Endometriosis: Comorbid Conditions
By Irem Onur
In the study of Dr. Boneva et al., from Atlanta, GA, the United States which has recently been published in the journal Frontiers in Pediatrics evaluated the impact of endometriosis on the health of women with chronic fatigue syndrome (CFS). The authors compared…
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Control on endometriosis progression by a "tyrosine kinase inhibitor"
By Irem Onur
B cells, which are important players of the immune system, are increased in the blood and peritoneal cavity of endometriosis patients. Activation of B cells and the presence of anti-endometrial autoantibodies have been also been described in women with endometriosis,…
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By Murat OsmanTransvaginal Ultrasound and the Imaging of Endometriosis
By Murat Osman
Ultrasonography (US) is an imaging tool that uses sound waves to produce a two-dimensional picture inside of the body. The ultrasonography has become especially useful in the assessment of gynecologic pathologies such as endometriosis. Depending on the severity of endometriosis,…
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Analogous pathways of peritoneal tumor wound healing and endometriosis.
By Selma Oransay
Endometriosis, diagnosed around 10-15% of women population in their reproductive period, is a chronically progressive inflammatory disease to cause peritoneal lesions while spreading into the abdominal cavity. The pathophysiology of the adhesions between the peritoneum and pelvic organs can be…
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Could a defect in phagocytosis cause endometriosis?
By Yu Yu
The macrophages are important immune cells in the peritoneal cavity because they function to remove aberrant cells or tissues by the process of phagocytosis. In endometriosis, there is an increased number of peritoneal macrophages and heightened production of inflammation molecules…
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Anti-angiogenic treatment for endometriosis
By Dr. Youngran Park
Endometriosis is a benign, estrogen-dependent gynecological disorder. The wide variety of surgical and medical treatment has been applied for treating endometriosis, but a definitive therapy has not been achieved so far. Thus, new therapeutic strategies need to be developed. Among…
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Endometrial single cells to contribute preexisting endometriosis.
By Dr. Youngran Park
Endometriosis is an estrogen-dependent inflammatory disease. This disease affects approximately 10% of reproductive-aged women and 20% to 50% of infertile women. Multiple hypotheses have been proposed for the origin of endometriosis. Retrograde menstruation is believed to take part by the…
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Antibiotic therapy for endometriosis
By Yu Yu
Current treatments for endometriosis are surgery and hormone therapy; however, these approaches may have significant side effects and do not prevent a recurrence. Therefore, alternative treatment modalities for endometriosis is needed. Recently, the idea that endometriosis may be influenced by…
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The postoperative functional outcomes of deep infiltrating endometriosis
By Hale Goksever Celik
Rectosigmoid endometriosis is defined as the infiltration of the bowel wall with the endometrial-like glands and stroma, reaching at least the muscular layer. The most commonly involved sites are the rectum and sigmoid colon. For the management of deep infiltrating…
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Bladder Endometriosis
By Demet Candaş Green
Bladder endometriosis is rare – about 1-2% of women with endometriosis may have endometrial lesions in their urinary tract. Diagnosis of bladder endometriosis is difficult because of its nonspecific symptoms such as frequent urination, pelvic pain, and burning sensation when…
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Can early-life exposures affect endometriosis development later in life?
By Demet Candaş Green
Endometriosis is a complex disease with possible multifactor contributors. So far, inflammatory, immunogenic, genetic, and environmental factors have all been associated with endometriosis. In addition, it is possible that different types of endometriosis lesions – peritoneal, ovarian, and deep infiltrating…
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Choosing the Right Technique for Deep Colorectal Endometriosis
By Dr. Youngran Park
Endometriosis is a benign gynecologic condition, histologically defined by the presence of ectopic endometrium outside the endometrial cavity. Three clinical presentations of endometriosis have been described and could coexist in the pelvis: peritoneal endometriosis, ovarian endometriosis, and deep infiltrating endometriosis.…
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Impact of Menstrual Symptoms on Everyday Life
By Dr. Youngran Park
Menstrual symptoms, including heavy menstrual bleeding, dysmenorrhea, and significant perimenstrual mood disorders, are common gynecological conditions. About 30% of women consider their menstrual bleeding heavy, and 34–94% of women experience pain during their menstrual period. Menstrual symptoms have a significant…
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Preoperative factors to predict unresponsiveness in women undergoing endometriosis surgery
By Hale Goksever Celik
Endometriosis is defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. Despite extensive research, the optimal management of endometriosis still remains unclear. Several treatment options include analgesic medication, hormonal treatments, and surgical intervention. There is…
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Menstrual blood-derived stem cells
By Selma Oransay
Chen et al. from the Center of Diagnosis and Treatment of İnfectious Disease, Zhejiang University, China penned this recent review in the Journal of Stem Cell Research Therapy which is presenting the clinical potential of MenSCs (Menstrual blood-derived stem cells). …
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Efficacy of an antibiotic, clarithromycin for endometriosis
By Yu Yu
Laparoscopic surgery is the standard treatment for advanced stages of endometriosis, followed by postoperative modalities including to progesterone, antiprogestogens, estrogen-progesterone combinations, danazol, and gonadotropin-releasing hormone agonists to reduce recurrence after surgery. However, these drugs interfere with ovulation and fertility. The…
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Self-management of endometriosis symptoms: from Australia
By Demet Candaş Green
Effective self-management techniques and lifestyle changes may play an important role in the management of endometriosis symptoms by many women. Due to various reasons such as limited effectiveness of some medications, potential side effects, availability of medical resources, self-desire to…
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Bowel endometriosis: What you need to know
By Demet Candaş Green
When the endometrial tissue infiltrates the intestinal walls and reaches inside the intestines, this condition is called "bowel endometriosis". It is estimated that between 3.8% and 37% of women with endometriosis are affected by bowel endometriosis. The endometriosis lesions infiltrating…
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Endometriosis and female pelvic pain in all aspects
By Hale Goksever Celik
Endometriosis is defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity. The prevalence of the disease ranges between 6-10% in reproductive-aged women. However, endometriosis is more frequently encountered in women with chronic pelvic pain and…
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Vaginal Sexual Intercourse during Menstruation
By Irem Onur
Mazokopakis and Samonis from Greece examined and discussed the vaginal sexual intercourse during menstruation from a biblical as well as a modern medical point of view in their paper published in MAEDICA – a Journal of Clinical Medicine in September 2018.…
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Surgical techniques for rectosigmoid endometriosis, and functional outcomes
By Hale Goksever Celik
Rectosigmoid endometriosis is defined as the infiltration of bowel wall with the endometrial-like glands and stroma, reaching at least the muscular layer. Rectosigmoid endometriosis is encountered in approximately 8-12% of patients with a diagnosis of endometriosis. The most commonly involved…
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Is the mystery for progression of endometriosis hiding out in abnormally located endometrial cells?
By Selma Oransay
This prospective study was conducted by Hapangama et al. in Research İnstute of the University of Liverpool, UK, and the results have recently published in the Journal of Human Reproduction. The authors hypothesized that abnormally located endometrial basalis-like (SSEA1/nSOX9+)cells could be contributing to…
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Endometriosis-associated pain control by contraceptive implant or intrauterine system
By Hale Goksever Celik
Endometriosis is defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. The most common symptoms are dysmenorrhea, dyspareunia, and chronic pelvic pain, all of which affect the quality of women’s lives. Several studies investigating the…
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Factors related to delay in endometriosis diagnosis
By Nasuhi Engin Aydin
Dr. Moniek van der Zanden, a gynecologist from Netherlands has recently made a nationwide survey on the impact of key recommendations of the European Society of Human Reproduction and Embryology (ESHRE) guidelines on endometriosis and aimed to assess factors influencing diagnostic delay of…
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Pelvic pain, congenital genital tract anomalies and endometriosis
By Hale Goksever Celik
Any failure during development and differentiation of female genital tract results in congenital tract anomalies. The origin of the hymen is the union of the caudal portion of the paramesonephric ducts and the urogenital sinus. It functions as a mechanical…
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Further Results From the FEELING Study Published
By Özge Özkaya
Some women are more likely to develop deep infiltrating endometriosis according to the further analysis of the results of the FEELING study. These are women who: are married, are older, have siblings, have had a prior pregnancy, or for whom…
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Immune dysregulation in endometriosis
By Yu Yu
The connection between endometriosis and the immune system has long been proposed. However, to date, there is no real consensus on whether immune adaptations actually facilitate endometriotric lesion progression or they are a consequence of endometriosis re-occurrence. Thus, this article…
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A Brief Review of Endometriosis
By Timur Seckin
Endometriosis is a common disease among women of reproductive age. It is more frequently seen among women without prior pregnancies, women with a family history of endometriosis, and women with abnormal menstrual periods. Peiris et al., researchers from the United…
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Endometriosis: A review on anatomic principles and the management
By Irem Onur
In the study of Alimi et al. which has been published in the journal Cureus, various aspects of endometriosis such as the pathophysiology, the anatomy, the pain mechanism, the perineural spread theory, clinical manifestations, diagnosis, and imaging, infertility, unusual cases,…
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The use of Elagolix in Women with Liver and Kidney Impairments
By Özge Özkaya
Elagolix may be used in women with moderate liver impairment, when necessary, for up to six months at a dose of 150 mg a day, according to a study published in the scientific journal Clinical Pharmacology in Drug Development. The…
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The pain and its severity in deeply infiltrating endometriosis patients
By Selma Oransay
Liang et al. from the Department of Obstetrics and Gynecology of the First Affiliated Hospital of Sun Yat-sen University, China, recently published an interesting paper in the Journal of Pain Research, a prospective study to reveal the relationship between neurogenesis and other potential…
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Is Physical Exercise Effective in Endometriosis?
By Hale Goksever Celik
Endometriosis is defined as the localization of endometrial tissue outside the uterine cavity. Dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility are mostly encountered symptoms of endometriosis. Although there are several theories explaining the pathogenesis of endometriosis, the exact pathogenesis still has…
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The diagnosis and management of endometriosis in Korea
By Selma Oransay
The Korean Society of Endometriosis has scrutinized the present published literature of endometriosis in the domestic and international platform to provide new guidelines and the clinical management of the disease. The study was recently published in the journal "Obstetrics and Gynecology…
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Best endometriosis articles of the past year.
By Selma Oransay
Dr.Stowall, from the Department of Obstetrics and Gynecology of Methodist Hospital, Dallas, Texas, USA penned this letter and recently published it in the Journal of Obstetrics and Gynecology to show his remarks of importance on four best publications of the…
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Suffering in Silence
By Deniz Kocas
Although quantitative and qualitative studies have established that endometriosis has a negative impact on multiple domains of quality of life, the majority of qualitative studies to date have used focus groups and interviews. These data collection methods may limit disclosure…
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Non-assisted reproductive technology treatment: Is it effective in infertile patients with advanced endometriosis?
By Hale Goksever Celik
The marriage and childbearing ages delay due to the life-style changes in developed countries. As a result, advanced age becomes a major concern in infertility treatments which consist of non-ART and ART modalities. Non-ART treatments include mild ovarian stimulation together…
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Parametrial endometriosis: A harder form of endometriosis
By Hale Goksever Celik
Deep infiltrating endometriosis is the most severe manifestation of endometriosis, affecting 20% of all patients with endometriosis. It is defined as the infiltration of ectopic endometrial tissue under the peritoneum, pelvic structures, and the organ walls such as the uterosacral…
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Quality of life for women with endometriosis
By Irem Onur
Endometriosis symptoms may cause difficulties in daily activities and social life, altering general health and personal relationships and severely decrease the quality of life. Yoldemir T. evaluates the factors affecting the quality of life in endometriosis patients and the management strategies in…
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Vitamin D and Endometriosis
By Nasuhi Engin Aydin
Scientists from Milan, Italy reviewed the effects of vitamin D on the reproductive health, and in particular "endometriosis" in their article which appeared in International Journal of Molecular Sciences. Vitamin D (VD), is a steroid hormone that is activated in…
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Endometriosis, Pain and Quality of Life
By Deniz Kocas
Although studies show that pain in endometriosis is associated with decreased health-related quality of life (HRQoL), details as to which pain symptoms contribute to such a decline have not been explored. For the first time in this study, researchers from…
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Laparoscopic surgery of endometriosis through three compartments
By Selma Oransay
This case study which is published in the J. of Minimally İnvasive Gynecology is the video demonstration of Collin et al who performed the laparoscopic operation of their patient in Gynecologic Surgery Department of Strasburg Hospital University, France. 37 years old…
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Fighting with endometriosis
By Irem Onur
Maduro M.R. reviewed three separate studies on potential new targets to successfully manage endometriosis in her recent paper titled “Novel Strategies to Fight Endometriosis” published in the journal Reproductive Sciences. In the autotransplantation rat model of Torres-Reveron et al., the…
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Reduced pain and increased fertiliy rates after surgery for colorectal endometriosis
By Selma Oransay
This prospective cohort study which recently published in AOGS by Hudelist et al. from Oslo University, Norway is about their one hundred thirty-four laparoscopic operations of DIE cases performed between 2011 and 2016, in a tertiary center in Oslo. The…
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How to evaluate ureteral endometriosis : A review of the literature
By Selma Oransay
In this recently published review of the literature, Barra et al. from Genova, Italy intend to provide a useful tool to guide physicians in the management of deep infiltrating endometriosis. Authors elected 67 abstracts from Pubmed and Medline in accordance with PRISMA…
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Endometriosis in adolescents
By Irem Onur
Dr. Mama S. T. from Cooper University Hospital, Camden, New Jersey, USA, recently has published his review on advances in the management of endometriosis in the adolescent in the journal “Current Opinion Obstetrics and Gynecology”. In adolescence, there is a…
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Endometriosis as a chronic disease: The benefits for the patients
By Selma Oransay
Rebecca O'Hara et al. from Monash University, Melbourne, Australia, recently published their qualitative case study in the Journal "Australian Health Review", to build a National Policy about endometriosis considering as a chronic disease. In Australia, long-term complex diseases are managed…
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How are endometriosis patients managed clinically?
By Irem Onur
This review paper by Falcone and Flyckt, entitled “Clinical Management of Endometriosis” published in the journal Obstetrics & Gynecology aims to summarize the current strategies for treating endometriosis patients with pain, pelvic dysfunction, and subfertility related to their disease. There are many…
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Women recommended laparoscopy for chronic pelvic pain
By Irem Onur
Chronic pelvic pain is a diagnostic and therapeutic dilemma. It has many etiologies in many organ systems. Clinician and patient factors affect the management of chronic pelvic pain. Mirowska-Allen K.L. et al. have recently published an article titled, “The characteristics of…
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Complementary treatments for endometriosis symptoms: acupuncture, exercise, electrotherapy, or yoga?
By Yu Yu
Endometriosis is associated with debilitating symptoms in some women including dysmenorrhea, chronic pelvic pain, deep dyspareunia, dyschezia, and dysuria. There are a few therapeutic options to treat these symptoms; however, only a few studies have considered treating the pain symptoms…
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By Kasthuri NairGnRH Analogues Not Beneficial For Superovulation and Intrauterine Insemination
By Kasthuri Nair
Bansal et al, a group of authors from the All India Institute of Medical Sciences, recently published a paper titled “The Role of GnRH Analogues in Improving Outcome in Women Undergoing Superovulation and Intrauterine Insemination after Surgical Correction of Mild…
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Therapeutic potential of ginseng based compound in preclinical models of endometriosis
By Yu Yu
Currently, the drug option for women with endometriosis mainly focus on reducing estrogens levels (e.g., progestins, androgens, gonadotropin-releasing hormone (GnRH) agonists, and aromatase inhibitors). However, these therapies can have low effectiveness with frequent recurrence and considerable side effects. Therefore, there…
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Health-related quality of life in women with Endometriosis and Rheumatoid Arthritis
By Murat Osman
Endometriosis is a chronic inflammatory disease that is defined by the presence of ectopic endometrial tissue outside of the uterus. Unfortunately, endometriosis continues to be a leading cause of chronic pelvic pain and long-term morbidity in women of reproductive age.…
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N-acetyl cysteine, alpha lipoic acid and bromelain improved endometriosis-associated pelvic pain
By Yu Yu
Oxidative stress has been implicated in many processes that lead to the development and progression of endometriosis. Typically, women with endometriosis have to endure pelvic pain which negatively impacts their quality of life. Pelvic pain can be chronic and related…
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Endometriosis Development: Pathogenesis and genomics
By Selma Oransay
In this review recently published in the International Journal of Molecular Sciences, Baranow et al from Saint Petersburg, Russia, hypothesize the existence of an endometriosis development genetic program (EMDP) that governs the origin of endometrium stem cells programmed for endometriosis; their transition…
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Commentary on major developments in the pathophysiology of endometriosis
By Nasuhi Engin Aydin
This commentary article by Dr. Warren G. Foster, from MacMaster University, Canada that appeared at Biology of Reproduction, is highly valuable for its leading role in endometriosis research. Although endometriosis is a common disease affecting up to 10% of women,…
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The pathogenesis of endometriosis : New discoveries with clinical impact
By Nasuhi Engin Aydin
In this recent review article that appeared in Current Women’s Health Reviews, compiled by researchers from the Department of Molecular Cell Biology and Human Genetics, Institute of Cell Biology and Neuroscience Frankfurt, Germany the following important points in regard to the molecular and cellular pathogenesis of…
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Predictors of psychological distress
By Deniz Kocas
Studies have now established that endometriosis can negatively impact mental health and quality of life, however, some studies show that not all women with endometriosis are necessarily more distressed than healthy women. This suggests that individual differences may explain women’s’…
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Oral Contraceptives and Low-Cost Progestins to Reduce Endometriosis-Associated Pain
By Özge Özkaya
Most women with endometriosis-associated pain did not feel the need to use expensive progestin or undergo surgery. Instead, they were satisfied with a low-cost progestin to treat their symptoms. This is according to a study published in the journal Fertility…
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How do adolescent girls and boys perceive symptoms suggestive of endometriosis among their peers?
By Dr. Youngran Park
Endometriosis, a chronic condition characterized by cells similar to the uterine lining that exist outside of the uterus, is estimated to impact 10% of women of reproductive age. In the USA, that approximates to some 7.4 million women. Endometriosis has…
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The comparison of Chinese women in terms of risk factors, genetics and treatment of endometriosis
By Hale Goksever Celik
Endometriosis is characterized by endometrial implants outside of the uterine cavity. There is a wide spectrum of symptoms of this disease including dysmenorrhea, chronic pelvic pain, dyspareunia, extragenital symptoms. The pathogenesis of endometriosis appears to be multifactorial, including ectopic endometrial…
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New Target for Endometriosis Treatment?
By Özge Özkaya
NR4A1 could be a novel target for the treatment of endometriosis, according to a study published in the scientific journal Cell Physiology and Biochemistry. NR4A1 is a receptor protein involved in cell division, inflammation, and programmed cell death. The development…
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Contraceptives for the management of endometriosis pain
By Murat Osman
Endometriosis is a common gynecologic disease that affects many women of reproductive age and is associated with significant morbidity. One of the treatment options for women with endometriosis is the use of oral contraceptives (OCPs) for pain management. However, its…
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Ambiguous experience: Destructive or Constructive
By Deniz Kocas
A diagnostic delay of 4-12 years is reported among women with endometriosis, which is explained by the lack of awareness of endometriosis as a medical condition among patients and healthcare professionals. In searching for a diagnosis, patients encounter many healthcare…
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Difficulties Associated with Diagnosing Ascites and Encapsulating Peritonitis in Endometriosis
By Kasthuri Nair
De Magalhães et al. recently published a paper titled “Ascites and Encapsulating Peritonitis in Endometriosis: a Systematic Review with a Case Report” in Revista Brasileira de Ginecologia e Obstetrícia. The team from the Universidade Federal do Ceará and the Universidade…
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A clearer picture of "endometriosis after menopause"
By Irem Onur
Delfin Avendano Tan and Marie Josephine Guanlao Almeria are obstetrician-gynecologists from the Philippines. They recently published a review article titled "Postmenopausal endometriosis: drawing a clearer picture". In this paper, the authors discussed the pathogenesis, risk factors, and management of postmenopausal…
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Therapeutic strategies involving uterine stem cells in reproductive medicine
By Murat Osman
Stem cells are undifferentiated cells that often serve to regenerate tissue in states of injury or apoptosis. The endometrium has progenitor cells that replace tissue lost after each menstrual cycle. It has been postulated that excessive stem cell recruitment to…
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Abnormal Regulation of Pathways Seen in Endometriosis
By Kasthuri Nair
Sikora et al., a team from the Medical University of Silesia in Katowice, published a study in the Archives of Gynecology and Obstetrics titled “The role of complement components C1q, MBL and C1 inhibitor in the pathogenesis of endometriosis.” It has been said that complement system…
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Managing of endometriosis and associated ovarian cancer risk
By Yu Yu
According to a number of studies, endometriosis is associated with moderate increase in ovarian cancer risk. This risk is elevated in subjects with a long-standing history of untreated ovarian endometriosis. Endometriosis is particularly associated with risk for certain histological subtypes…
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Emerging medical treatments for endometriosis
By Murat Osman
Endometriosis is a disease whereby uterine tissue grows outside the walls of the uterus to the surfaces of other tissues in the body. It is a chronic disease and relies upon estrogen to grow and survive. Current medical therapies take…
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Could Endometriosis Be Caused by Bacteria?
By Özge Özkaya
A new concept called the bacterial contamination hypothesis in endometriosis has been proposed for the first time by researchers in Japan. This means that new potential therapies approaches could exist for this condition in addition to the conventional estrogen-suppressing therapies.…
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Investigational drugs for the treatment of endometriosis
By Yu Yu
Endometriosis treatment involves surgery and medical therapies. Surgery can improve the associated pain, quality of life and sexual function, even though it is technically challenging with potential risks of complications. Medical therapy is often aimed to ameliorate pain symptoms and…
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How Does Endometriosis Affect the Sexual Satisfaction of Men?
By Özge Özkaya
Although the majority of men whose partner has endometriosis are satisfied or very satisfied with their sexual relationship, the proportion of men who are not sexually satisfied is higher among those whose partner has endometriosis compared to those whose partner…
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Highlights Thoracic Endometriosis Case
By Kasthuri Nair
Dr. Tamer Seckin, MD, the co-founder of the Endometriosis Foundation of America, was recently featured in a New York Times article titled “The Woman Was Fit and Healthy. Why Did Her Lung Mysteriously Collapse?” The article describes a rather unusual…
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The use of histone deacetylase inhibitors for the treatment of endometriosis
By Murat Osman
Histone deacetylase inhibitors prevent the deacetylation of specific gene sequences thereby allowing the increased transcription of certain genes. Trichostatin A, a histone deacetylase inhibitor, has been seen to induce the expression of a pro-apoptotic gene called nonsteroidal anti-inflammatory drug-activated gene…
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Menstrual Effluent Can Change the Future of Endometriosis
By Kasthuri Nair
During Endometriosis Awareness Month, Warren et al. published a paper entitled “Analysis of menstrual effluent: diagnostic potential for endometriosis” in Molecular Medicine. This paper relies heavily on the theory of retrograde menstruation, where menstrual effluent flows into the peritoneal cavity.…
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Collaboration Between the Surgical and Medical Experts of Endometriosis Needed
By Murat Osman
The authors of this perspective article aim to initiate a dialogue regarding the current evidence regarding the surgical and medical treatment of endometriosis. In their view, the quality of data regarding the outcomes of surgery for endometriosis is lacking and…
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The effect of anti-rheumatic drugs on endometriosis therapeutic outcomes
By Yu Yu
Endometriosis can be described as an autoimmune disease because the abnormalities associated with T and B cell function and various autoantibodies. Although endometriosis has not been found to associate with some severe autoimmune disorders such as systemic lupus erythematosus, it…
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Diagnostic and treatment guidelines for gastrointestinal and genitourinary endometriosis.
By Murat Osman
Endometriosis may affect the pelvic reproductive system, but it can also be found in non-reproductive organs such as the gastrointestinal and urinary tract. The article outlined below discusses the diagnosis and management of genitourinary and gastrointestinal endometriosis. Gastrointestinal endometriosis: The…
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Diagnosis and management of adolescent endometriosis
By Murat Osman
Early onset endometriosis (EOE) is characterized by endometriosis that begins around menarche or early adolescence. Recent evidence suggests that this form of endometriosis may have a different pathogenic origin than that of adult-onset endometriosis. This opinion article suggests that early…
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Changes in Complement Proteins Affect Infertility in Women with Endometriosis
By Kasthuri Nair
Palomino et al. recently published a paper titled “The endometria of women with endometriosis exhibit dysfunctional expression of complement regulatory proteins during the mid-secretory phase” in the Journal of Reproductive Immunology where they look at the expression of CRPs during the menstrual cycle of…
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Do Adolescents and Adults Experience Endometriosis Differently?
By Özge Özkaya
Symptoms of endometriosis seem to be the same between women surgically diagnosed during adolescence and those diagnosed as adults, according to a study published in the American Journal of Obstetrics and Gynecology. For both age groups, pelvic pain was severe,…
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Dienogest Use Over A Prolonged Period of Time
By Kasthuri Nair
There are not a lot of treatments on the market for endometriosis; however, Dienogest (DNG), a progestin that has high selective progesterone activity along with low androgenic activity, has been found to reduce endometriosis-associated pain. Lee et al. recently published…
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By Laura ArdighieriEffects of osteopathic manipulative therapy in patients with colorectal endometriosis
By Laura Ardighieri
Alternative treatments have been used for colorectal endometriosis, between them Chinese medicine, acupuncture and more recently osteopathic manipulative therapy. The osteopathic manipulative therapy has been shown to reduce the chronic pain working on muscular contractions due to vicious analgesic positions.…
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Endometriosis early pointers
By Yu Yu
Endometriosis can take a long time to diagnose, thus associated with prolonged symptoms of pain, subfertility and patient frustration/demoralization. It can be difficult to diagnose clinically because the symptoms are common and non-specific so that GP can misconceive them as…
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Treatment of minimal endometriosis in infertile women
By Demet Candaş Green
For women with mild/minimal endometriosis, European Society of Human Reproduction and Embryology (ESHRE) recommends the removal of endometriotic lesions to improve fertility and increase pregnancy rates. For women undergoing assisted reproductive treatment, there is ongoing debate whether surgical removal of…
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High-Mobility Group Box 1 Expression Could Lead to Disease Progression
By Kasthuri Nair
Endometriosis can often be characterized by the aberrant ectopic growth of endometriotic stromal cells (ESCs); however, research has yet to elucidate the mechanism driving this growth. The authors of this study, namely Shimizu et al., believe that the high-mobility group…
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An association of negative coping strategies on the presence of chronic symptoms associated with endometriosis
By Murat Osman
Endometriosis is often a long-term condition that becomes disabling and can affect the quality of life and mental health of many women. One area of endometriosis that needs to be focused on is the psychosocial-related issues of endometriosis and how…
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A New Treatment Time-Table for Controlling Endometriosis-Associated Pelvic Pain
By Kasthuri Nair
It is no secret that Endometriosis is an extremely painful disease. Unfortunately, science has yet to determine a treatment that can effectively treat the disease or the associated pain. In their paper titled “Ethinylestradiol 20 mg/drospirenone 3 mg in a…
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Is there any association between menstrual pain and ovarian cancer?
By Yu Yu
Inflammation may be important in ovarian carcinogenesis. Epidemiological studies show that inflammatory conditions such as endometriosis and pelvic inflammatory disease have been associated with an increased risk of ovarian cancer, while regular use of non-steroidal anti-inflammatory drugs has reduced associated…
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Overview of NICE Endometriosis Guidelines
By Kasthuri Nair
In this article titled “Diagnosis and management of endometriosis: summary of NICE guidance,” Kuznetsov et al. talk through the recent endometriosis guidelines set forth by The National Institute for Health Care and Excellence (NICE). The BMJ publication hopes to elucidate…
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Breast Feeding Can Reduce the Risk of Endometriosis
By Kasthuri Nair
In their publication titled “History of breast feeding and risk of incident endometriosis: prospective cohort study,” Farland et al. examine the benefits of breast feeding. The authors initially hypothesize that the length of lactation in women that have been pregnant…
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Updates in the Field of Endometriosis
By Kasthuri Nair
A lot of progress has been made thus far in the field of endometriosis. Research has discovered various genetic and epigenetic components involved in endometriosis. There has also been a progression in the diagnosis and treatment of the disease since…
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By Vishaan NurseyArcyriaflavin A Decreases Endometriosis Cell Viability and Proliferation
By Vishaan Nursey
The purpose of this research topic was to determine whether Arcyriaflavin A could serve as a potential new therapeutic option for those suffering from Endometriosis. Arcyriaflavin A is a Cyclin D1 inhibitor. Cyclin D1 regulates the cell cycle by interacting…
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Human Endometrium-Derived Mesenchymal Stem Cells for Cell-based Therapies
By Yu Yu
Mesenchymal stem cells are a promising candidate for cell-based targeted therapies because they have characteristics such as self-renewal, multipotency, low immunogenicity, and non-oncogenicity. It has the capacity to migrate to sites of inflammation including in endometrial lesions and tumor. Most…
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The dose of the GnRHa after laparoscopic surgery
By Yu Yu
Laparoscopic surgery is considered a routine way to diagnose and remove endometriosis. The primary concern with laparoscopic surgery is the recurrence of endometriosis because of incomplete lesion excision. Hence, the challenge is to decrease endometriosis recurrence rate. Gonadotrophin-releasing hormone agonist…
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Surgical treatment of colonic endometriosis
By Demet Candaş Green
In this study, the authors provide a brief report published in the journal "The American Surgeon" which retrospectively reviewed the therapy outcomes in eight consecutive patients who had a laparoscopic surgical intervention for deeply infiltrating endometriosis (DIE) at Anne Arundel Medical Center. The…
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Glycodelin and altered endometrial function in endometriosis
By Yu Yu
A laparoscopic examination is the only diagnostic tool for endometriosis to date. Since the procedure is invasive, there has been much effort by researchers to develop a biomarker for non-invasive diagnosis of endometriosis. To this end, there has been growing…
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Reduced vascularization in ovarian endometriomas associated with less pain
By Yu Yu
Angiogenesis, i.e., the development of new blood vessels is believed to play an important role in endometriosis pathogenesis and symptoms. Endometriosis is associated and requires neovascularization to proliferate, invade surrounding normal structure in order to establish an endometriotic lesion. Ovarian…
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Combo Therapy of Micronized palmitoylethanolamide/trans-polydatin for Endometriosis Pain
By Kasthuri Nair
Endometriosis is a painful illness and many researchers in the field work to offer women with the disease some form of respite from the suffering. Indraccolo, Indraccolo, and Mignini are three such researchers and they recently published a paper titled…
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By Elisabetta KuhnReevaluating response and failure of medical treatment of endometriosis
By Elisabetta Kuhn
Endometriosis is a chronic disease affecting more than 10% of women in the fertile age and causing "pain" symptoms, that may require medical therapy. Most medical treatments used for endometriosis exert a hormonal mechanism to curtail estrogen effects either locally…
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Dienogest for endometriosis pain in clinical practice
By Yu Yu
Dienogest is a synthetic progestogen that has been marketed as a medical treatment for endometriosis. Previous randomized controlled clinical trials have shown that it is effective in women with endometriosis at different stages of the disease. Given its recent introduction,…
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The Most Cost Effective Medical Treatment to Prevent Recurrent Endometriosis
By Özge Özkaya
A new study conducted in China found that a class of drugs called Gonadotropin-releasing hormone agonists (GnRH-a) is more cost effective for the treatment of recurrent endometriosis despite the fact that they are more expensive than oral contraceptives. The results…
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By Asli Bahadirli TalbottInhibition of key neurotransmitter could reduce endometriosis-related pain
By Asli Bahadirli Talbott
This study published in the scientific journalMolecular MedicineReports[link] by Lian et al. from Shanghai, China, aims to explore the relationship between transient receptor potential vanilloid type 1 (TRPV1) and endometriosis-associated pain. Pain is the most common symptom for women with…
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Symptoms of Endometriosis May Be Partly Caused by an Infection and Be Treated with Antibiotics
By Özge Özkaya
Women with endometriosis are more frequently diagnosed with chronic endometritis compared to other women found a study published in the medical journal Fertility and Sterility. According to the authors, this finding suggests that although no causal relationship between these two…
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The Benefits of Primary Surgery
By Kasthuri Nair
Ahmad, Hussin, and Ahmad recently conducted a cohort study, and they published the results within an article titled “An evaluation of the quality of life in women with endometriosis who underwent primary surgery: a 6-month follow-up in Sabah Women &…
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Naturally Occurring Plant Product May Hold Promise for the Treatment of Endometriosis
By Özge Özkaya
A natural plant product called apigenin might be a potential new treatment for endometriosis according to a study published in the Journal of Cell Physiology. “ […] Apigenin is a potential novel therapeutic agent to overcome current limitations in the…
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Retinoic Acid Signaling Involved in Endometrial Decidualization
By Murat Osman
Decidualization occurs in the eutopic endometrium during the luteal phase and is controlled by signaling pathways such as cyclic adenosine monophosphate (cAMP) and progesterone. Researchers from the Northwestern University School of Medicine reported in their recent paper entitled "Altered Retinoid…
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Pregnancy Risks Associated with Severe Endometriosis
By Kasthuri Nair
Living with endometriosis can be painful and challenging; however, the challenges increase for women that are pregnant and have this disease. Recently, BJOG published an article titled “The ominous association between severe endometriosis, in-vitro fertilization, and placenta praevia: Raising awareness,…
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How Resveratrol is effective in endometriosis?
By Asli Bahadirli Talbott
In their review paper, Mohammadi and Arablou recommend using Resveratrol, a plant-derived compound, for the treatment of endometriosis. Resveratrol is abundant in nature and can be found in many different plant species, fungi, berries, peanuts, legumes, and grasses; however, grapes…
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Women with endometriosis suffer from anxiety and depression
By Demet Candaş Green
Endometriosis is considered a disabling condition that may significantly affect social relationships, sexuality and mental health of patients. Women who suffer from endometriosis report high levels of anxiety and depression and other psychological disorders. In this review article, the authors…
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Asian Women at Higher Risk of Endometriosis and Less Likely to Conceive with IVF but not Because of their Endometriosis
By Özge Özkaya
The rate of endometriosis is higher amongst women of Asian origin confirms a study published in the Journal of Assisted Reproduction and Genetics. In addition, pregnancy rates following fertility treatments are lower in this group of women. However, this does…
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TFF3 May Be Involved in Endometriosis Research Suggests
By Özge Özkaya
Levels of a protein called TFF3 are significantly increased in the peritoneal cavity (the abdominal space) of women with endometriosis, found a study published in the scientific journal Reproductive Sciences. This increase was in line with levels of other known…
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A Cholesterol-Lowering Drug and an Anticancer Drug May Be Alternative Treatments Against Endometriosis
By Özge Özkaya
Crestor (rosuvastatin), a cholesterol lowering drug and Avastin (bevacizumab), an anticancer drug are more efficient in reducing endometriosis in rats compared to progesterone medication, according to a study published in the journal Gynecological Endocrinology. For the study, researchers led by…
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How rats can help improve colon endometriosis treatment in humans
By Demet Candaş Green
Colorectal endometriosis forms about 3–37% of all deep infiltrating endometriosis (DIE) cases. DIE is a highly invasive type of endometriosis, occurs when ovarian endometriomas overgrow and rupture, releasing their contents into the abdominal and pelvic cavity, resulting in the formation…
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By Ezio RosatoWomen with Endometriosis Undergoing Surgery Often Require Further Treatment
By Ezio Rosato
Recurrence of endometriosis is common even in women who underwent surgery, a new study confirmed. This suggests that women with endometriosis should be closely followed up even after treatment with surgery. For the study published online in the Journal of…
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Ultrasound Ablation to Treat Endometriosis
By Murat Osman
Further Understanding: Deeply infiltrating endometriosis (DIE) often presents in the rectosigmoid colon in women with endometriosis and can be the major cause of gastrointestinal and pelvic symptoms. This preliminary study focuses on the utility of High-Intensity Focused Ultrasound (HIFU) in…
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Elagolix (ABT-620) for endometriosis pain?
By Yu Yu
Elagolix is an orally active gonadotropin-releasing hormone antagonist that has just recently completed Phase 3 clinical trial for endometriosis-associated pain (NCT01931670). The review article by Alessandro et al in Archives of Gynecology and Obstetrics summarized the current research findings on…
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